ID TM159_HUMAN Reviewed; 161 AA.
AC Q96B96; A6NMA9; B4DEC1; O00323;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 02-NOV-2016, entry version 108.
DE RecName: Full=Promethin;
DE AltName: Full=Transmembrane protein 159;
GN Name=TMEM159;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP VARIANT ASP-154.
RC TISSUE=Heart;
RX PubMed=15589683; DOI=10.1016/j.biochi.2004.09.015;
RA Yu S., Viswakarma N., Batra S.K., Sambasiva Rao M., Reddy J.K.;
RT "Identification of promethin and PGLP as two novel up-regulated genes
RT in PPARgamma1-induced adipogenic mouse liver.";
RL Biochimie 86:743-761(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ASP-154.
RC TISSUE=Cerebellum, and Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R.,
RA Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L.,
RA Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E.,
RA Harris P.C., Venter J.C., Adams M.D.;
RT "Genome duplications and other features in 12 Mb of DNA sequence from
RT human chromosome 16p and 16q.";
RL Genomics 60:295-308(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP SER-107.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- INTERACTION:
CC Q8NI60:ADCK3; NbExp=5; IntAct=EBI-7055862, EBI-745535;
CC Q9UGQ2:CACFD1; NbExp=4; IntAct=EBI-7055862, EBI-8652492;
CC Q05329:GAD2; NbExp=3; IntAct=EBI-7055862, EBI-9304251;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96B96-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96B96-2; Sequence=VSP_056078;
CC Note=No experimental confirmation available.;
CC -!- TISSUE SPECIFICITY: Expressed at high levels in the heart and
CC skeletal muscle. Expressed at low levels in kidney, small
CC intestine, lung and liver. {ECO:0000269|PubMed:15589683}.
CC -!- SIMILARITY: Belongs to the TMEM159 family. {ECO:0000305}.
DR EMBL; AY212918; AAO52682.1; -; mRNA.
DR EMBL; AK074667; BAC11122.1; -; mRNA.
DR EMBL; AK293557; BAG57032.1; -; mRNA.
DR EMBL; AF001550; AAB67598.1; -; Genomic_DNA.
DR EMBL; AC008551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015812; AAH15812.1; -; mRNA.
DR CCDS; CCDS10595.1; -. [Q96B96-1]
DR CCDS; CCDS76841.1; -. [Q96B96-2]
DR RefSeq; NP_001288698.1; NM_001301769.1. [Q96B96-1]
DR RefSeq; NP_001288700.1; NM_001301771.1. [Q96B96-1]
DR RefSeq; NP_001288702.1; NM_001301773.1.
DR RefSeq; NP_001288703.1; NM_001301774.1.
DR RefSeq; NP_001288704.1; NM_001301775.1. [Q96B96-2]
DR RefSeq; NP_065155.3; NM_020422.5. [Q96B96-1]
DR RefSeq; XP_005255496.1; XM_005255439.4. [Q96B96-2]
DR RefSeq; XP_006721129.1; XM_006721066.2. [Q96B96-2]
DR UniGene; Hs.258212; -.
DR ProteinModelPortal; Q96B96; -.
DR BioGrid; 121403; 7.
DR IntAct; Q96B96; 5.
DR MINT; MINT-8201794; -.
DR STRING; 9606.ENSP00000233047; -.
DR iPTMnet; Q96B96; -.
DR PhosphoSitePlus; Q96B96; -.
DR BioMuta; TMEM159; -.
DR DMDM; 313104024; -.
DR EPD; Q96B96; -.
DR MaxQB; Q96B96; -.
DR PaxDb; Q96B96; -.
DR PeptideAtlas; Q96B96; -.
DR PRIDE; Q96B96; -.
DR DNASU; 57146; -.
DR Ensembl; ENST00000233047; ENSP00000233047; ENSG00000011638. [Q96B96-1]
DR Ensembl; ENST00000261388; ENSP00000261388; ENSG00000011638. [Q96B96-1]
DR Ensembl; ENST00000451578; ENSP00000409879; ENSG00000011638. [Q96B96-2]
DR Ensembl; ENST00000572599; ENSP00000460687; ENSG00000011638. [Q96B96-1]
DR GeneID; 57146; -.
DR KEGG; hsa:57146; -.
DR UCSC; uc002dif.5; human. [Q96B96-1]
DR CTD; 57146; -.
DR DisGeNET; 57146; -.
DR GeneCards; TMEM159; -.
DR H-InvDB; HIX0012870; -.
DR HGNC; HGNC:30136; TMEM159.
DR HPA; HPA018033; -.
DR HPA; HPA063509; -.
DR MIM; 611304; gene.
DR neXtProt; NX_Q96B96; -.
DR OpenTargets; ENSG00000011638; -.
DR PharmGKB; PA145147935; -.
DR eggNOG; ENOG410IZ20; Eukaryota.
DR eggNOG; ENOG41126AQ; LUCA.
DR GeneTree; ENSGT00390000006420; -.
DR HOGENOM; HOG000069886; -.
DR HOVERGEN; HBG094018; -.
DR InParanoid; Q96B96; -.
DR OMA; WFSPRPL; -.
DR OrthoDB; EOG091G0SFC; -.
DR PhylomeDB; Q96B96; -.
DR TreeFam; TF335782; -.
DR ChiTaRS; TMEM159; human.
DR GenomeRNAi; 57146; -.
DR PRO; PR:Q96B96; -.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000011638; -.
DR CleanEx; HS_TMEM159; -.
DR ExpressionAtlas; Q96B96; baseline and differential.
DR Genevisible; Q96B96; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029709; Promethin/TMEM159.
DR PANTHER; PTHR14275:SF0; PTHR14275:SF0; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW Polymorphism; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 161 Promethin.
FT /FTId=PRO_0000279535.
FT TRANSMEM 55 75 Helical. {ECO:0000255}.
FT TRANSMEM 80 100 Helical. {ECO:0000255}.
FT TRANSMEM 102 122 Helical. {ECO:0000255}.
FT CARBOHYD 29 29 N-linked (GlcNAc...). {ECO:0000255}.
FT CARBOHYD 141 141 N-linked (GlcNAc...). {ECO:0000255}.
FT VAR_SEQ 30 30 N -> NSKLPQHSRISLDSDDGVSRLGSAG (in
FT isoform 2).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_056078.
FT VARIANT 97 97 F -> L (in dbSNP:rs35345508).
FT /FTId=VAR_057765.
FT VARIANT 107 107 G -> S (in dbSNP:rs1046480).
FT {ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_030923.
FT VARIANT 154 154 E -> D (in dbSNP:rs1063087).
FT {ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15589683}.
FT /FTId=VAR_030924.
SQ SEQUENCE 161 AA; 17522 MW; 196B502EE203BA7E CRC64;
MAKEEPQSIS RDLQELQKKL SLLIDSFQNN SKVVAFMKSP VGQYLDSHPF LAFTLLVFIV
MSAVPVGFFL LIVVLTTLAA LLGVIILEGL VISVGGFSLL CILCGLGFVS LAMSGMMIAS
YVVVSSLISC WFSPRPLTQQ NTSCDFLPAM KSAEFEGLYQ E
//
|
