ID TM134_HUMAN Reviewed; 195 AA.
AC Q9H6X4; Q08AK4; Q6PJN3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 02-NOV-2016, entry version 95.
DE RecName: Full=Transmembrane protein 134;
GN Name=TMEM134;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9H6X4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H6X4-2; Sequence=VSP_023452;
CC Name=3;
CC IsoId=Q9H6X4-3; Sequence=VSP_023453, VSP_023454;
CC -!- SIMILARITY: Belongs to the TMEM134/TMEM230 family. {ECO:0000305}.
DR EMBL; AK025402; BAB15126.1; -; mRNA.
DR EMBL; BC013883; AAH13883.1; -; mRNA.
DR EMBL; BC125134; AAI25135.1; -; mRNA.
DR CCDS; CCDS41678.1; -. [Q9H6X4-2]
DR CCDS; CCDS8167.1; -. [Q9H6X4-1]
DR RefSeq; NP_001072118.1; NM_001078650.2. [Q9H6X4-2]
DR RefSeq; NP_001072119.1; NM_001078651.2.
DR RefSeq; NP_079400.1; NM_025124.3. [Q9H6X4-1]
DR UniGene; Hs.288761; -.
DR ProteinModelPortal; Q9H6X4; -.
DR SMR; Q9H6X4; -.
DR BioGrid; 123167; 3.
DR STRING; 9606.ENSP00000312615; -.
DR iPTMnet; Q9H6X4; -.
DR PhosphoSitePlus; Q9H6X4; -.
DR SwissPalm; Q9H6X4; -.
DR DMDM; 74718574; -.
DR MaxQB; Q9H6X4; -.
DR PaxDb; Q9H6X4; -.
DR PeptideAtlas; Q9H6X4; -.
DR PRIDE; Q9H6X4; -.
DR Ensembl; ENST00000308022; ENSP00000312615; ENSG00000172663. [Q9H6X4-1]
DR Ensembl; ENST00000393877; ENSP00000377455; ENSG00000172663. [Q9H6X4-2]
DR Ensembl; ENST00000545682; ENSP00000438439; ENSG00000172663. [Q9H6X4-3]
DR GeneID; 80194; -.
DR KEGG; hsa:80194; -.
DR UCSC; uc001olq.3; human. [Q9H6X4-1]
DR CTD; 80194; -.
DR GeneCards; TMEM134; -.
DR HGNC; HGNC:26142; TMEM134.
DR HPA; HPA043744; -.
DR neXtProt; NX_Q9H6X4; -.
DR OpenTargets; ENSG00000172663; -.
DR PharmGKB; PA143485657; -.
DR eggNOG; KOG4753; Eukaryota.
DR eggNOG; ENOG4111TWA; LUCA.
DR GeneTree; ENSGT00390000011766; -.
DR HOGENOM; HOG000145514; -.
DR HOVERGEN; HBG093689; -.
DR InParanoid; Q9H6X4; -.
DR OMA; RSYHACC; -.
DR OrthoDB; EOG091G0P6K; -.
DR PhylomeDB; Q9H6X4; -.
DR TreeFam; TF323560; -.
DR BioCyc; ZFISH:ENSG00000172663-MONOMER; -.
DR ChiTaRS; TMEM134; human.
DR GenomeRNAi; 80194; -.
DR PRO; PR:Q9H6X4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000172663; -.
DR CleanEx; HS_TMEM134; -.
DR ExpressionAtlas; Q9H6X4; baseline and differential.
DR Genevisible; Q9H6X4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008590; DUF872_TM.
DR Pfam; PF05915; DUF872; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 195 Transmembrane protein 134.
FT /FTId=PRO_0000279485.
FT TOPO_DOM 1 122 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 123 143 Helical. {ECO:0000255}.
FT TOPO_DOM 144 154 Extracellular. {ECO:0000255}.
FT TRANSMEM 155 175 Helical. {ECO:0000255}.
FT TOPO_DOM 176 195 Cytoplasmic. {ECO:0000255}.
FT MOD_RES 93 93 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q8R0J4}.
FT VAR_SEQ 136 150 Missing (in isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_023452.
FT VAR_SEQ 136 136 V -> GPAQCLALETELGELPGEGLCLGHLQLRWWVSRAGG
FT GSPRPHHCSCPHPRGSVCVQC (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_023453.
FT VAR_SEQ 137 195 Missing (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_023454.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 57 193 ipfam:DUF872 [T]
SQ SEQUENCE 195 AA; 21586 MW; D20FFFF9531DA68A CRC64;
MSAARPQFSI DDAFELSLED GGPGPESSGV ARFGPLHFER RARFEVADED KQSRLRYQNL
ENDEDGAQAS PEPDGGVGTR DSSRTSIRSS QWSFSTISSS TQRSYNTCCS WTQHPLIQKN
RRVVLASFLL LLLGLVLILV GVGLEATPSP GVSSAIFFVP GFLLLVPGVY HVIFIYCAVK
GHRGFQFFYL PYFEK
//
|
