Entry sw:SRRM4_MOUSE

ID   SRRM4_MOUSE             Reviewed;         608 AA.
AC   Q8BKA3; Q8R1S5; Q9CW37;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   02-NOV-2016, entry version 95.
DE   RecName: Full=Serine/arginine repetitive matrix protein 4;
DE   AltName: Full=Neural-specific serine/arginine repetitive splicing factor of 100 kDa;
DE            Short=Neural-specific SR-related protein of 100 kDa;
DE            Short=nSR100;
GN   Name=Srrm4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum, and Eye;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, RNA-BINDING, AND
RP   PHOSPHORYLATION.
RX   PubMed=19737518; DOI=10.1016/j.cell.2009.06.012;
RA   Calarco J.A., Superina S., O'Hanlon D., Gabut M., Raj B., Pan Q.,
RA   Skalska U., Clarke L., Gelinas D., van der Kooy D., Zhen M.,
RA   Ciruna B., Blencowe B.J.;
RT   "Regulation of vertebrate nervous system alternative splicing and
RT   development by an SR-related protein.";
RL   Cell 138:898-910(2009).
CC   -!- FUNCTION: Splicing factor specifically required for neural cell
CC       differentiation. Acts in conjuction with nPTB/PTBP2 by binding
CC       directly to its regulated target transcripts and promotes neural-
CC       specific exon inclusion in many genes that function in neural cell
CC       differentiation. Required to promote the inclusion of neural-
CC       specific exon 10 in nPTB/PTBP2, leading to increased expression of
CC       neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16
CC       in DAAM1 in neuron extracts. {ECO:0000269|PubMed:19737518}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19737518}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8BKA3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BKA3-2; Sequence=VSP_029639;
CC   -!- TISSUE SPECIFICITY: Specifically expressed in neuronal cells (at
CC       protein level). Expressed in adult nervous system and sensory
CC       organ tissues. {ECO:0000269|PubMed:19737518}.
CC   -!- PTM: Phosphorylated. {ECO:0000269|PubMed:19737518}.
CC   -!- SIMILARITY: Belongs to the nSR100 family. {ECO:0000305}.
DR   EMBL; AK005085; BAB23809.1; -; mRNA.
DR   EMBL; AK053836; BAC35548.1; -; mRNA.
DR   EMBL; BC024130; AAH24130.1; -; mRNA.
DR   EMBL; BC056392; AAH56392.1; -; mRNA.
DR   CCDS; CCDS19601.1; -. [Q8BKA3-1]
DR   RefSeq; NP_081162.1; NM_026886.3. [Q8BKA3-1]
DR   RefSeq; XP_006530519.1; XM_006530456.3. [Q8BKA3-1]
DR   UniGene; Mm.146779; -.
DR   ProteinModelPortal; Q8BKA3; -.
DR   STRING; 10090.ENSMUSP00000075488; -.
DR   iPTMnet; Q8BKA3; -.
DR   PhosphoSitePlus; Q8BKA3; -.
DR   PaxDb; Q8BKA3; -.
DR   PRIDE; Q8BKA3; -.
DR   Ensembl; ENSMUST00000076124; ENSMUSP00000075488; ENSMUSG00000063919. [Q8BKA3-1]
DR   Ensembl; ENSMUST00000139425; ENSMUSP00000144367; ENSMUSG00000063919. [Q8BKA3-2]
DR   GeneID; 68955; -.
DR   KEGG; mmu:68955; -.
DR   UCSC; uc008zfb.1; mouse. [Q8BKA3-2]
DR   UCSC; uc008zfc.1; mouse. [Q8BKA3-1]
DR   CTD; 84530; -.
DR   MGI; MGI:1916205; Srrm4.
DR   eggNOG; ENOG410IEGN; Eukaryota.
DR   eggNOG; ENOG4112C96; LUCA.
DR   GeneTree; ENSGT00730000111247; -.
DR   HOGENOM; HOG000013098; -.
DR   InParanoid; Q8BKA3; -.
DR   OMA; PCLECAE; -.
DR   OrthoDB; EOG091G0FNP; -.
DR   PhylomeDB; Q8BKA3; -.
DR   PRO; PR:Q8BKA3; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   Bgee; ENSMUSG00000063919; -.
DR   CleanEx; MM_1500001A10RIK; -.
DR   ExpressionAtlas; Q8BKA3; baseline and differential.
DR   Genevisible; Q8BKA3; MM.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003729; F:mRNA binding; IDA:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IMP:UniProtKB.
DR   GO; GO:0006397; P:mRNA processing; IDA:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IMP:MGI.
DR   GO; GO:0043484; P:regulation of RNA splicing; IDA:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
DR   InterPro; IPR029360; SRRM_C.
DR   Pfam; PF15230; SRRM_C; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Differentiation;
KW   mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome; RNA-binding.
FT   CHAIN         1    608       Serine/arginine repetitive matrix protein
FT                                4.
FT                                /FTId=PRO_0000311912.
FT   COMPBIAS    109    171       Lys-rich.
FT   COMPBIAS    123    605       Ser-rich.
FT   COMPBIAS    404    593       Arg-rich.
FT   VAR_SEQ       1    488       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_029639.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       455    518       ipfam:SRRM_C [T]
SQ   SEQUENCE   608 AA;  67860 MW;  16DBEF71B68C301C CRC64;
     MASLQQGEKQ LFEKFWKGTF KAVATPRPES IIVASITARK PMPRTEPQSS LLLPDQDGPS
     EKLGQHLAPE ALGTNSWGRE KACRELDPAR AHSASQDRDP TPPPSSRGKK KKKKSTRKKR
     RRSPSYSPSP VKKKKKKSSK KHKRHRSFSK KRRHSSCSPK SKRREEKRHK KQSRSRKSHR
     HRHHRCPSRS QSSELRSPSC ESRHRGRSPE EGRKSRRTHS RRCSKNHCKV SPDARSSHLP
     SQPLPRLGFL SARGVITGSG SAADLFSKSA SPLAATRGRS QEYDSGNDTS SPPSTQTSSA
     RSRGQEKGSP GGDLSKSRDL NCGNTSDSGN SFTTSSPQNK GAVLETVSPA CRSRESRGFQ
     SPCLQCAEVK KSSLVPSTAR SSPIKECSRS SSYTSTRSSS PSSRSPNPRA SPRYTRSRST
     SSEKRSYSRS PSYSSKSGKR SPPSRSSRSR RSPSYSRYSP SRERDLKYGE KEPQPRERAR
     RRRRSYSPMR KRRRDSPSHL EARRITSARK RPIPYYRPSP SSSSSLSSAS SWYSSSSSSS
     SSSSRSPSRS YSRSRSPSRS HSSRSQTRSR TRTSRSSSSR SLSLGSRSRS RNRSLSYSSA
     ESYASTRR
//