ID SPAC7_HUMAN Reviewed; 195 AA.
AC Q96KW9; Q5T8L1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 18-JAN-2017, entry version 95.
DE RecName: Full=Sperm acrosome-associated protein 7 {ECO:0000312|HGNC:HGNC:29575};
DE Flags: Precursor;
GN Name=SPACA7 {ECO:0000312|HGNC:HGNC:29575}; Synonyms=C13orf28;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-111.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22495889; DOI=10.1530/REP-11-0270;
RA Korfanty J., Toma A., Wojtas A., Rusin A., Vydra N., Widlak W.;
RT "Identification of a new mouse sperm acrosome-associated protein.";
RL Reproduction 143:749-757(2012).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] TRP-25.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal
RT cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Involved in fertilization. Seems not to play a direct
CC role in sperm-egg binding or gamete fusion.
CC {ECO:0000250|UniProtKB:Q9D2S4}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9D2S4}.
CC Cytoplasmic vesicle, secretory vesicle, acrosome
CC {ECO:0000269|PubMed:22495889}. Cytoplasmic vesicle, secretory
CC vesicle, acrosome lumen {ECO:0000250|UniProtKB:Q9D2S4}.
CC Note=Localized in perinuclear pro-acrosomal granules in round
CC spermatides. Localized between the inner and outer acrosomal
CC membranes (matrix or lumen) in spermatozoa. Secreted during
CC acrosome exocytosis. {ECO:0000250|UniProtKB:Q9D2S4}.
CC -!- TISSUE SPECIFICITY: Expressed in spermatozoa (at protein level)
CC (PubMed:22495889). {ECO:0000269|PubMed:22495889}.
DR EMBL; AL160033; CAI14451.1; -; Genomic_DNA.
DR EMBL; BC016750; AAH16750.1; -; mRNA.
DR CCDS; CCDS9524.1; -.
DR RefSeq; NP_660291.2; NM_145248.4.
DR UniGene; Hs.97592; -.
DR ProteinModelPortal; Q96KW9; -.
DR SMR; Q96KW9; -.
DR BioGrid; 125763; 2.
DR IntAct; Q96KW9; 1.
DR iPTMnet; Q96KW9; -.
DR PhosphoSitePlus; Q96KW9; -.
DR BioMuta; SPACA7; -.
DR DMDM; 125863833; -.
DR PaxDb; Q96KW9; -.
DR PRIDE; Q96KW9; -.
DR TopDownProteomics; Q96KW9; -.
DR Ensembl; ENST00000283550; ENSP00000283550; ENSG00000153498.
DR Ensembl; ENST00000610393; ENSP00000480272; ENSG00000275865.
DR GeneID; 122258; -.
DR KEGG; hsa:122258; -.
DR UCSC; uc001vsd.3; human.
DR CTD; 122258; -.
DR GeneCards; SPACA7; -.
DR HGNC; HGNC:29575; SPACA7.
DR neXtProt; NX_Q96KW9; -.
DR OpenTargets; ENSG00000153498; -.
DR OpenTargets; ENSG00000275865; -.
DR PharmGKB; PA147358486; -.
DR eggNOG; ENOG410J5PZ; Eukaryota.
DR eggNOG; ENOG411168G; LUCA.
DR GeneTree; ENSGT00390000018090; -.
DR HOVERGEN; HBG058480; -.
DR InParanoid; Q96KW9; -.
DR OMA; CCWQETE; -.
DR OrthoDB; EOG091G0Z0J; -.
DR PhylomeDB; Q96KW9; -.
DR TreeFam; TF338340; -.
DR BioCyc; ZFISH:ENSG00000153498-MONOMER; -.
DR GenomeRNAi; 122258; -.
DR PRO; PR:Q96KW9; -.
DR Proteomes; UP000005640; Chromosome 13.
DR Bgee; ENSG00000153498; -.
DR CleanEx; HS_C13orf28; -.
DR ExpressionAtlas; Q96KW9; baseline and differential.
DR Genevisible; Q96KW9; HS.
DR GO; GO:0043160; C:acrosomal lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007162; P:negative regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:0007338; P:single fertilization; IBA:GO_Central.
DR InterPro; IPR029301; SPACA7.
DR PANTHER; PTHR40384; PTHR40384; 1.
DR Pfam; PF15307; SPACA7; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Cytoplasmic vesicle; Fertilization; Glycoprotein;
KW Polymorphism; Reference proteome; Secreted; Signal.
FT SIGNAL 1 24 {ECO:0000255}.
FT CHAIN 25 195 Sperm acrosome-associated protein 7.
FT /FTId=PRO_0000274330.
FT CARBOHYD 62 62 N-linked (GlcNAc...). {ECO:0000255}.
FT CARBOHYD 159 159 N-linked (GlcNAc...). {ECO:0000255}.
FT VARIANT 25 25 R -> W (in a colorectal cancer sample;
FT somatic mutation; dbSNP:rs376712879).
FT {ECO:0000269|PubMed:16959974}.
FT /FTId=VAR_035675.
FT VARIANT 111 111 V -> D (in dbSNP:rs10816).
FT {ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_030260.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 19 126 ipfam:SPACA7 [T]
SQ SEQUENCE 195 AA; 21466 MW; 09E285617F560FD8 CRC64;
MAVSQGDGTL CFVLLLCCWQ ETELRPRTVI PGSPTEIPFS SKQEDMSELL DEILVQEILD
LNKTTPSEMP STASTLSTPL HAGIDENYQA GGSENYHELL ENLQFSPGIE VKISNDEANA
NANLHGDPSE NYRGPQVSPG SEKSVSSKEK NSKNTQYENL SILDQILQNI GRSSGNIFHK
EQQRTSAQRR SQGSQ
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