MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Superoxide dismutase [Mn] 1, mitochondrial; EC=1.15.1.1; Flags: Precursor; |
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| MyHits synonyms | SODM1_CAEEL , P31161 , EEA518B2800379F7 |
 Legends: 1, Manganese. {ECO:0000250}; 2, TRANSIT Mitochondrion. {ECO:0000250}; 3, ipat:SOD_MN [T]; 4, TURN {ECO:0000244|PDB:3DC6}; 5, HELIX {ECO:0000244|PDB:3DC6}; 6, STRAND {ECO:0000244|PDB:3DC6}.
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ID SODM1_CAEEL Reviewed; 221 AA.
AC P31161;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 02-NOV-2016, entry version 123.
DE RecName: Full=Superoxide dismutase [Mn] 1, mitochondrial;
DE EC=1.15.1.1;
DE Flags: Precursor;
GN Name=sod-2; Synonyms=sdm-1; ORFNames=F10D11.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Suzuki N., Ishii N., Suzuki K.;
RT "Cloning and characterization of manganese superoxide dismutase gene
RT in C.elegans.";
RL Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8905235; DOI=10.1093/dnares/3.3.171;
RA Suzuki N., Inokuma K., Yasuda K., Ishii N.;
RT "Cloning, sequencing and mapping of a manganese superoxide dismutase
RT gene of the nematode Caenorhabditis elegans.";
RL DNA Res. 3:171-174(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for
RT investigating biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC produced within the cells and which are toxic to biological
CC systems.
CC -!- CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
CC -!- SUBUNIT: Homotetramer.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix.
CC -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC family. {ECO:0000305}.
DR EMBL; D12984; BAA02363.1; -; mRNA.
DR EMBL; D85499; BAA12821.1; -; Genomic_DNA.
DR EMBL; Z81057; CAB02913.1; -; Genomic_DNA.
DR PIR; JC5122; JC5122.
DR RefSeq; NP_492290.1; NM_059889.4.
DR UniGene; Cel.112; -.
DR PDB; 3DC6; X-ray; 1.80 A; A/C=25-221.
DR PDBsum; 3DC6; -.
DR ProteinModelPortal; P31161; -.
DR SMR; P31161; -.
DR STRING; 6239.F10D11.1.2; -.
DR iPTMnet; P31161; -.
DR EPD; P31161; -.
DR PaxDb; P31161; -.
DR PeptideAtlas; P31161; -.
DR PRIDE; P31161; -.
DR EnsemblMetazoa; F10D11.1.1; F10D11.1.1; WBGene00004931.
DR EnsemblMetazoa; F10D11.1.2; F10D11.1.2; WBGene00004931.
DR GeneID; 172632; -.
DR KEGG; cel:CELE_F10D11.1; -.
DR UCSC; F10D11.1.1; c. elegans.
DR CTD; 172632; -.
DR WormBase; F10D11.1; CE09323; WBGene00004931; sod-2.
DR eggNOG; KOG0876; Eukaryota.
DR eggNOG; COG0605; LUCA.
DR GeneTree; ENSGT00390000011877; -.
DR HOGENOM; HOG000013583; -.
DR InParanoid; P31161; -.
DR KO; K04564; -.
DR OMA; DHHGNVG; -.
DR OrthoDB; EOG091G0MVL; -.
DR PhylomeDB; P31161; -.
DR Reactome; R-CEL-3299685; Detoxification of Reactive Oxygen Species.
DR EvolutionaryTrace; P31161; -.
DR PRO; PR:P31161; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00004931; -.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0097249; C:mitochondrial respiratory chain supercomplex; IDA:WormBase.
DR GO; GO:0005739; C:mitochondrion; IDA:WormBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:WormBase.
DR GO; GO:0004784; F:superoxide dismutase activity; IDA:WormBase.
DR GO; GO:0019430; P:removal of superoxide radicals; IMP:WormBase.
DR InterPro; IPR001189; Mn/Fe_SOD.
DR InterPro; IPR019833; Mn/Fe_SOD_BS.
DR InterPro; IPR019832; Mn/Fe_SOD_C.
DR InterPro; IPR019831; Mn/Fe_SOD_N.
DR PANTHER; PTHR11404; PTHR11404; 1.
DR Pfam; PF02777; Sod_Fe_C; 1.
DR Pfam; PF00081; Sod_Fe_N; 1.
DR PIRSF; PIRSF000349; SODismutase; 1.
DR PRINTS; PR01703; MNSODISMTASE.
DR SUPFAM; SSF46609; SSF46609; 1.
DR SUPFAM; SSF54719; SSF54719; 1.
DR PROSITE; PS00088; SOD_MN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Manganese; Metal-binding;
KW Mitochondrion; Oxidoreductase; Reference proteome; Transit peptide.
FT TRANSIT 1 24 Mitochondrion. {ECO:0000250}.
FT CHAIN 25 221 Superoxide dismutase [Mn] 1,
FT mitochondrial.
FT /FTId=PRO_0000032876.
FT METAL 50 50 Manganese. {ECO:0000250}.
FT METAL 98 98 Manganese. {ECO:0000250}.
FT METAL 182 182 Manganese. {ECO:0000250}.
FT METAL 186 186 Manganese. {ECO:0000250}.
FT TURN 35 41 {ECO:0000244|PDB:3DC6}.
FT HELIX 44 52 {ECO:0000244|PDB:3DC6}.
FT HELIX 54 74 {ECO:0000244|PDB:3DC6}.
FT HELIX 78 83 {ECO:0000244|PDB:3DC6}.
FT HELIX 85 103 {ECO:0000244|PDB:3DC6}.
FT HELIX 114 124 {ECO:0000244|PDB:3DC6}.
FT HELIX 127 139 {ECO:0000244|PDB:3DC6}.
FT STRAND 143 152 {ECO:0000244|PDB:3DC6}.
FT TURN 153 156 {ECO:0000244|PDB:3DC6}.
FT STRAND 157 164 {ECO:0000244|PDB:3DC6}.
FT HELIX 169 173 {ECO:0000244|PDB:3DC6}.
FT STRAND 176 182 {ECO:0000244|PDB:3DC6}.
FT HELIX 185 187 {ECO:0000244|PDB:3DC6}.
FT HELIX 189 192 {ECO:0000244|PDB:3DC6}.
FT HELIX 196 202 {ECO:0000244|PDB:3DC6}.
FT HELIX 203 206 {ECO:0000244|PDB:3DC6}.
FT HELIX 209 219 {ECO:0000244|PDB:3DC6}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 112 215 ipfam:Sod_Fe_C [T]
FT MYHIT 182 189 ipat:SOD_MN [T]
FT MYHIT 25 106 ipfam:Sod_Fe_N [T]
SQ SEQUENCE 221 AA; 24537 MW; EEA518B2800379F7 CRC64;
MLQNTVRCVS KLVQPITGVA AVRSKHSLPD LPYDYADLEP VISHEIMQLH HQKHHATYVN
NLNQIEEKLH EAVSKGNVKE AIALQPALKF NGGGHINHSI FWTNLAKDGG EPSAELLTAI
KSDFGSLDNL QKQLSASTVA VQGSGWGWLG YCPKGKILKV ATCANQDPLE ATTGLVPLFG
IDVWEHAYYL QYKNVRPDYV NAIWKIANWK NVSERFAKAQ Q
//
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