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Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7

DescriptionRecName: Full=Semaphorin-like protein 139; Flags: Precursor;
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MyHits synonymsSEMA_ECTVM , Q8JL80 , BD7B76AF04C0838D
match map segment
ismart:Sema iprf:SEMA ipfam:Sema  
Legends: 1, SIGNAL {ECO:0000255}; 2, STRAND {ECO:0000244|PDB:3NVN}; 3, TURN {ECO:0000244|PDB:3NVN}; 4, HELIX {ECO:0000244|PDB:3NVN}. 
ID   SEMA_ECTVM              Reviewed;         399 AA.
AC   Q8JL80;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   02-NOV-2016, entry version 57.
DE   RecName: Full=Semaphorin-like protein 139;
DE   Flags: Precursor;
GN   Name=EVM139; Synonyms=SEMA;
OS   Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Orthopoxvirus.
OX   NCBI_TaxID=265874;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7747448; DOI=10.1006/viro.1995.1208;
RA   Mossman K., Upton C., Buller R.M., McFadden G.;
RT   "Species specificity of ectromelia virus and vaccinia virus
RT   interferon-gamma binding proteins.";
RL   Virology 208:762-769(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10725549; DOI=10.1016/S0168-1702(99)00135-5;
RA   Chen N., Buller R.M., Wall E.M., Upton C.;
RT   "Analysis of host response modifier ORFs of ectromelia virus, the
RT   causative agent of mousepox.";
RL   Virus Res. 66:155-173(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9495531; DOI=10.1016/S0168-1702(97)00122-6;
RA   Wall E.M., Cao J.X., Chen N., Buller R.M.L., Upton C.;
RT   "A novel poxvirus gene and its human homolog are similar to an E. coli
RT   lysophospholipase.";
RL   Virus Res. 52:157-167(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Chen N., Danila M.I., Feng Z., Buller M.L., Wang C., Han X.,
RA   Lefkowitz E., Upton C.;
RT   "The genomic sequence of ectromelia virus, the causative agent of
RT   mousepox.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12941926; DOI=10.1128/JVI.77.18.10139-10146.2003;
RA   Ribas G., Rivera J., Saraiva M., Campbell R.D., Alcami A.;
RT   "Genetic variability of immunomodulatory genes in ectromelia virus
RT   isolates detected by denaturing high-performance liquid
RT   chromatography.";
RL   J. Virol. 77:10139-10146(2003).
RN   [6]
RP   INTERACTION WITH HOST VESPR.
RX   PubMed=9586637; DOI=10.1016/S1074-7613(00)80552-X;
RA   Comeau M.R., Johnson R., DuBose R.F., Petersen M., Gearing P.,
RA   VandenBos T., Park L., Farrah T., Buller R.M., Cohen J.I.,
RA   Strockbine L.D., Rauch C., Spriggs M.K.;
RT   "A poxvirus-encoded semaphorin induces cytokine production from
RT   monocytes and binds to a novel cellular semaphorin receptor, VESPR.";
RL   Immunity 8:473-482(1998).
RN   [7]
RP   FUNCTION.
RX   PubMed=15611227; DOI=10.4049/jimmunol.174.1.51;
RA   Walzer T., Galibert L., Comeau M.R., De Smedt T.;
RT   "Plexin C1 engagement on mouse dendritic cells by viral semaphorin
RT   A39R induces actin cytoskeleton rearrangement and inhibits integrin-
RT   mediated adhesion and chemokine-induced migration.";
RL   J. Immunol. 174:51-59(2005).
RN   [8]
RP   FUNCTION.
RX   PubMed=15657950; DOI=10.1002/eji.200425669;
RA   Walzer T., Galibert L., De Smedt T.;
RT   "Poxvirus semaphorin A39R inhibits phagocytosis by dendritic cells and
RT   neutrophils.";
RL   Eur. J. Immunol. 35:391-398(2005).
RN   [9]
RP   X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS) OF 15-399.
RX   PubMed=20727575; DOI=10.1016/j.cell.2010.07.040;
RA   Liu H., Juo Z.S., Shim A.H., Focia P.J., Chen X., Garcia K.C., He X.;
RT   "Structural basis of semaphorin-plexin recognition and viral mimicry
RT   from Sema7A and A39R complexes with PlexinC1.";
RL   Cell 142:749-761(2010).
CC   -!- FUNCTION: Acts as a semaphorin-like protein and binds to host
CC       plexin C1 receptor. May alter the movement of plexin C1-expressing
CC       cells including dendritic cells, monocytes, or granulocytes in the
CC       proximity of infected cells. May also regulate host cell
CC       cytoskeleton of neighboring cells to improve viral infection.
CC       {ECO:0000269|PubMed:15611227, ECO:0000269|PubMed:15657950}.
CC   -!- SUBUNIT: Interacts with host VESPR. {ECO:0000269|PubMed:9586637}.
CC   -!- INTERACTION:
CC       O60486:PLXNC1 (xeno); NbExp=3; IntAct=EBI-2927425, EBI-2927384;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 Sema domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00352}.
DR   EMBL; AF012825; AAM92444.1; -; Genomic_DNA.
DR   EMBL; AJ574801; CAE00473.1; -; Genomic_DNA.
DR   EMBL; AJ574802; CAE00474.1; -; Genomic_DNA.
DR   EMBL; AJ574803; CAE00475.1; -; Genomic_DNA.
DR   EMBL; AJ574804; CAE00476.1; -; Genomic_DNA.
DR   EMBL; AJ574805; CAE00477.1; -; Genomic_DNA.
DR   RefSeq; NP_671658.1; NC_004105.1.
DR   PDB; 3NVN; X-ray; 2.26 A; A=15-399.
DR   PDBsum; 3NVN; -.
DR   ProteinModelPortal; Q8JL80; -.
DR   SMR; Q8JL80; -.
DR   IntAct; Q8JL80; 1.
DR   GeneID; 951586; -.
DR   KEGG; vg:951586; -.
DR   KO; K06529; -.
DR   EvolutionaryTrace; Q8JL80; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   PANTHER; PTHR11036; PTHR11036; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Secreted; Signal.
FT   SIGNAL        1     14       {ECO:0000255}.
FT   CHAIN        15    399       Semaphorin-like protein 139.
FT                                /FTId=PRO_0000412614.
FT   DOMAIN       15    399       Sema. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00352}.
FT   STRAND       16     19       {ECO:0000244|PDB:3NVN}.
FT   STRAND       26     34       {ECO:0000244|PDB:3NVN}.
FT   STRAND       36     48       {ECO:0000244|PDB:3NVN}.
FT   STRAND       51     56       {ECO:0000244|PDB:3NVN}.
FT   STRAND       63     77       {ECO:0000244|PDB:3NVN}.
FT   TURN         79     81       {ECO:0000244|PDB:3NVN}.
FT   STRAND       84     87       {ECO:0000244|PDB:3NVN}.
FT   TURN         99    101       {ECO:0000244|PDB:3NVN}.
FT   STRAND      104    106       {ECO:0000244|PDB:3NVN}.
FT   STRAND      111    116       {ECO:0000244|PDB:3NVN}.
FT   STRAND      118    120       {ECO:0000244|PDB:3NVN}.
FT   STRAND      124    127       {ECO:0000244|PDB:3NVN}.
FT   STRAND      157    163       {ECO:0000244|PDB:3NVN}.
FT   STRAND      166    192       {ECO:0000244|PDB:3NVN}.
FT   STRAND      199    201       {ECO:0000244|PDB:3NVN}.
FT   TURN        202    205       {ECO:0000244|PDB:3NVN}.
FT   STRAND      211    215       {ECO:0000244|PDB:3NVN}.
FT   STRAND      218    221       {ECO:0000244|PDB:3NVN}.
FT   STRAND      226    234       {ECO:0000244|PDB:3NVN}.
FT   STRAND      239    246       {ECO:0000244|PDB:3NVN}.
FT   STRAND      248    250       {ECO:0000244|PDB:3NVN}.
FT   STRAND      253    258       {ECO:0000244|PDB:3NVN}.
FT   HELIX       259    268       {ECO:0000244|PDB:3NVN}.
FT   HELIX       295    303       {ECO:0000244|PDB:3NVN}.
FT   STRAND      306    311       {ECO:0000244|PDB:3NVN}.
FT   STRAND      315    317       {ECO:0000244|PDB:3NVN}.
FT   STRAND      327    332       {ECO:0000244|PDB:3NVN}.
FT   TURN        334    336       {ECO:0000244|PDB:3NVN}.
FT   STRAND      340    345       {ECO:0000244|PDB:3NVN}.
FT   STRAND      347    354       {ECO:0000244|PDB:3NVN}.
FT   TURN        355    357       {ECO:0000244|PDB:3NVN}.
FT   STRAND      360    364       {ECO:0000244|PDB:3NVN}.
FT   STRAND      369    389       {ECO:0000244|PDB:3NVN}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT         4    396       ismart:Sema [T]
FT   MYHIT         1    399       iprf:SEMA [T]
FT   MYHIT        61    344       ipfam:Sema [T]
SQ   SEQUENCE   399 AA;  45358 MW;  BD7B76AF04C0838D CRC64;
     MIPLLFILFY FTNCIEWHKF ETSEEIISTY LIDDVLYTGV NGAVYTFSNN ELNKTGLTNN
     NNYITTSIKV EDTLVCGTNN GNPKCWKIDG SEDPKYRGRG YAPYQNSKVT IISHNECVLS
     DINISKEGIK RWRRFDGPCG YDLYTADNVI PKDGVRGAFV DKDGTYDKVY ILFTDTIDTK
     RIVKIPYIAQ MCLNDEGGPS SLSSHRWSTF LKVELECDID GRSYRQIIHS KAIKTDNDTI
     LYVFFDSPYS KSALCTYSMN AIKHSFSTSK LGGYTKQLPS PAPGICLPAG KVVPHTTFDI
     IEQYNELDDI IKPLSQPIFE GPSGVKWFDI KEKENEHREY RIYFIKENTI YSFDTKSKQT
     RSAQVDARLF SVMVTSKPLF IADIGIGVGI PRMKKILKM
//