MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=DNA gyrase inhibitor {ECO:0000255|HAMAP-Rule:MF_01896}; |
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| MyHits synonyms | SBMC_SHIB3 , B2TYH1 , C85BCD23F28C274E |
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ID SBMC_SHIB3 Reviewed; 157 AA.
AC B2TYH1;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 02-NOV-2016, entry version 44.
DE RecName: Full=DNA gyrase inhibitor {ECO:0000255|HAMAP-Rule:MF_01896};
GN Name=sbmC {ECO:0000255|HAMAP-Rule:MF_01896}; Synonyms=gyrI;
GN OrderedLocusNames=SbBS512_E1226;
OS Shigella boydii serotype 18 (strain CDC 3083-94 / BS512).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=344609;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 3083-94 / BS512;
RA Rasko D.A., Rosovitz M., Maurelli A.T., Myers G., Seshadri R., Cer R.,
RA Jiang L., Ravel J., Sebastian Y.;
RT "Complete sequence of Shigella boydii serotype 18 strain BS512.";
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits the supercoiling activity of DNA gyrase. Acts
CC by inhibiting DNA gyrase at an early step, prior to (or at the
CC step of) binding of DNA by the gyrase. It protects cells against
CC toxins that target DNA gyrase, by inhibiting activity of these
CC toxins and reducing the formation of lethal double-strand breaks
CC in the cell. {ECO:0000255|HAMAP-Rule:MF_01896}.
CC -!- SUBUNIT: Interacts with DNA gyrase. {ECO:0000255|HAMAP-
CC Rule:MF_01896}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01896}.
CC -!- SIMILARITY: Belongs to the DNA gyrase inhibitor family.
CC {ECO:0000255|HAMAP-Rule:MF_01896}.
DR EMBL; CP001063; ACD07849.1; -; Genomic_DNA.
DR RefSeq; WP_001105415.1; NC_010658.1.
DR ProteinModelPortal; B2TYH1; -.
DR SMR; B2TYH1; -.
DR EnsemblBacteria; ACD07849; ACD07849; SbBS512_E1226.
DR KEGG; sbc:SbBS512_E1226; -.
DR PATRIC; 18669119; VBIShiBoy129590_1348.
DR HOGENOM; HOG000121896; -.
DR KO; K07470; -.
DR OMA; TPWYQFF; -.
DR Proteomes; UP000001030; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008657; F:DNA topoisomerase (ATP-hydrolyzing) inhibitor activity; IEA:UniProtKB-HAMAP.
DR Gene3D; 3.20.80.10; -; 1.
DR HAMAP; MF_01896; DNA_gyrase_inhibitor; 1.
DR InterPro; IPR010499; AraC_E-bd.
DR InterPro; IPR024911; DNA_gyrase_inhibitor_GyrI.
DR InterPro; IPR029442; GyrI-like.
DR InterPro; IPR011256; Reg_factor_effector_dom.
DR Pfam; PF06445; GyrI-like; 1.
DR SMART; SM00871; AraC_E_bind; 1.
DR SUPFAM; SSF55136; SSF55136; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Stress response.
FT CHAIN 1 157 DNA gyrase inhibitor.
FT /FTId=PRO_0000409707.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 152 ipfam:GyrI-like [T]
FT MYHIT 1 155 ihamap:DNA_gyrase_inhibitor [T]
FT MYHIT 1 153 ismart:AraC_E_bind [T]
SQ SEQUENCE 157 AA; 18081 MW; C85BCD23F28C274E CRC64;
MNYEIKQEEK RTVAGFHLVG PWEQTVKKGF EQLMMWVDSK NIVPKEWVAV YYDNPDETPA
EKLRCDTVVT VPGYFTLPEN SEGVILTEIT GGQYAVAVAR VVGDDFAKPW YQFFNSLLQD
SAYEMLPKPC FEVYLNNGAE DGYWDIEMYV AVQPKHH
//
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