ID RN222_HUMAN Reviewed; 220 AA.
AC A6NCQ9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 18-JAN-2017, entry version 82.
DE RecName: Full=RING finger protein 222;
GN Name=RNF222;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC {ECO:0000255|PROSITE-ProRule:PRU00175}.
DR EMBL; AC026130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45608.1; -.
DR RefSeq; NP_001140156.1; NM_001146684.2.
DR RefSeq; XP_011522280.1; XM_011523978.2.
DR RefSeq; XP_011522281.1; XM_011523979.2.
DR RefSeq; XP_011522282.1; XM_011523980.2.
DR RefSeq; XP_011522283.1; XM_011523981.2.
DR UniGene; Hs.526550; -.
DR ProteinModelPortal; A6NCQ9; -.
DR SMR; A6NCQ9; -.
DR BioGrid; 569148; 1.
DR STRING; 9606.ENSP00000343799; -.
DR iPTMnet; A6NCQ9; -.
DR PhosphoSitePlus; A6NCQ9; -.
DR BioMuta; RNF222; -.
DR PaxDb; A6NCQ9; -.
DR PRIDE; A6NCQ9; -.
DR Ensembl; ENST00000344001; ENSP00000343799; ENSG00000189051.
DR Ensembl; ENST00000399398; ENSP00000382330; ENSG00000189051.
DR GeneID; 643904; -.
DR KEGG; hsa:643904; -.
DR UCSC; uc010vuy.2; human.
DR CTD; 643904; -.
DR GeneCards; RNF222; -.
DR HGNC; HGNC:34517; RNF222.
DR HPA; HPA048916; -.
DR neXtProt; NX_A6NCQ9; -.
DR OpenTargets; ENSG00000189051; -.
DR PharmGKB; PA164725453; -.
DR eggNOG; ENOG410J277; Eukaryota.
DR eggNOG; ENOG411286J; LUCA.
DR GeneTree; ENSGT00390000002856; -.
DR HOGENOM; HOG000137599; -.
DR HOVERGEN; HBG054934; -.
DR InParanoid; A6NCQ9; -.
DR OMA; CPICRYV; -.
DR OrthoDB; EOG091G0KNP; -.
DR PhylomeDB; A6NCQ9; -.
DR TreeFam; TF333220; -.
DR BioCyc; ZFISH:G66-33601-MONOMER; -.
DR GenomeRNAi; 643904; -.
DR PRO; PR:A6NCQ9; -.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000189051; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0033768; C:SUMO-targeted ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0032184; F:SUMO polymer binding; IBA:GO_Central.
DR GO; GO:0008134; F:transcription factor binding; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0033234; P:negative regulation of protein sumoylation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR027370; Znf-RING_LisH.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Membrane; Metal-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1 220 RING finger protein 222.
FT /FTId=PRO_0000329085.
FT TRANSMEM 196 216 Helical. {ECO:0000255}.
FT ZN_FING 14 65 RING-type. {ECO:0000255|PROSITE-
FT ProRule:PRU00175}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 33 42 ipat:ZF_RING_1 [T]
FT MYHIT 14 65 iprf:ZF_RING_2 [T]
FT MYHIT 14 64 ismart:RING [T]
FT MYHIT 14 62 ipfam:zf-RING_UBOX [T]
SQ SEQUENCE 220 AA; 23767 MW; 67080B8736DBDD1B CRC64;
MSEGESKDSS GSECPVCYEK FRDLEGASRT LSCGHVFCHD CLVKYLLSTR VDGQVQRTLV
CPICRYVTFL SKKSSRWPSM LDKSSQTLAV PVGLPSVPPL DSLGHTNPLA ASSPAWRPPP
GQARPPGSPG QSAQLPLDLL PSLPRESQIF VISRHGMPLG EQDSVLPRRS LAELSEASLA
PRSARAFCCR SRALLLITLI AVVAVVAAIL PWVLLVRKQA
//
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