Entry sw:RL32_HUMAN

ID   RL32_HUMAN              Reviewed;         135 AA.
AC   P62910; B2R4Q3; P02433;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   30-NOV-2016, entry version 120.
DE   RecName: Full=60S ribosomal protein L32;
GN   Name=RPL32; ORFNames=PP9932;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3866218; DOI=10.1093/nar/13.24.8883;
RA   Young J.A.T., Trowsdale J.;
RT   "A processed pseudogene in an intron of the HLA-DP beta 1 chain gene
RT   is a member of the ribosomal protein L32 gene family.";
RL   Nucleic Acids Res. 13:8883-8891(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11875025; DOI=10.1101/gr.214202;
RA   Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S.,
RA   Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.;
RT   "The human ribosomal protein genes: sequencing and comparative
RT   analysis of 73 genes.";
RL   Genome Res. 12:379-390(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA   Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H.,
RA   Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y.,
RA   Shu H., Chen X., Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S.,
RA   Gu J.;
RT   "Large-scale cDNA transfection screening for genes related to cancer
RT   development and progression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   PROTEIN SEQUENCE OF 2-11; 84-93 AND 115-121, CLEAVAGE OF INITIATOR
RP   METHIONINE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Lung carcinoma;
RA   Bienvenut W.V., Vousden K.H., Lukashchuk N.;
RL   Submitted (MAR-2008) to UniProtKB.
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [10]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712; DOI=10.1002/pmic.201400617;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [11]
RP   STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
RX   PubMed=23636399; DOI=10.1038/nature12104;
RA   Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA   Wilson D.N., Beckmann R.;
RT   "Structures of the human and Drosophila 80S ribosome.";
RL   Nature 497:80-85(2013).
CC   -!- SIMILARITY: Belongs to the ribosomal protein L32e family.
CC       {ECO:0000305}.
DR   EMBL; X03342; CAA27048.1; -; mRNA.
DR   EMBL; AB061831; BAB79469.1; -; Genomic_DNA.
DR   EMBL; AF370435; AAQ15271.1; -; mRNA.
DR   EMBL; AK311909; BAG34850.1; -; mRNA.
DR   EMBL; CH471055; EAW64144.1; -; Genomic_DNA.
DR   EMBL; BC011514; AAH11514.1; -; mRNA.
DR   EMBL; BC070209; AAH70209.1; -; mRNA.
DR   CCDS; CCDS2614.1; -.
DR   PIR; S11393; R5HU32.
DR   RefSeq; NP_000985.1; NM_000994.3.
DR   RefSeq; NP_001007074.1; NM_001007073.1.
DR   RefSeq; NP_001007075.1; NM_001007074.1.
DR   UniGene; Hs.265174; -.
DR   PDB; 4UG0; EM; -; Le=1-135.
DR   PDB; 4V6X; EM; 5.00 A; Ce=1-135.
DR   PDB; 5AJ0; EM; 3.50 A; Ae=1-135.
DR   PDBsum; 4UG0; -.
DR   PDBsum; 4V6X; -.
DR   PDBsum; 5AJ0; -.
DR   ProteinModelPortal; P62910; -.
DR   SMR; P62910; -.
DR   BioGrid; 112080; 105.
DR   IntAct; P62910; 16.
DR   MINT; MINT-1149317; -.
DR   STRING; 9606.ENSP00000380156; -.
DR   iPTMnet; P62910; -.
DR   PhosphoSitePlus; P62910; -.
DR   SwissPalm; P62910; -.
DR   BioMuta; RPL32; -.
DR   DMDM; 51702809; -.
DR   EPD; P62910; -.
DR   MaxQB; P62910; -.
DR   PaxDb; P62910; -.
DR   PeptideAtlas; P62910; -.
DR   PRIDE; P62910; -.
DR   TopDownProteomics; P62910; -.
DR   DNASU; 6161; -.
DR   Ensembl; ENST00000396953; ENSP00000380156; ENSG00000144713.
DR   Ensembl; ENST00000396957; ENSP00000380158; ENSG00000144713.
DR   Ensembl; ENST00000429711; ENSP00000416429; ENSG00000144713.
DR   Ensembl; ENST00000435983; ENSP00000388674; ENSG00000144713.
DR   GeneID; 6161; -.
DR   KEGG; hsa:6161; -.
DR   UCSC; uc003bxl.4; human.
DR   CTD; 6161; -.
DR   GeneCards; RPL32; -.
DR   HGNC; HGNC:10336; RPL32.
DR   HPA; HPA047501; -.
DR   HPA; HPA051994; -.
DR   neXtProt; NX_P62910; -.
DR   OpenTargets; ENSG00000144713; -.
DR   PharmGKB; PA34719; -.
DR   eggNOG; KOG0878; Eukaryota.
DR   eggNOG; COG1717; LUCA.
DR   GeneTree; ENSGT00390000014729; -.
DR   HOGENOM; HOG000231288; -.
DR   HOVERGEN; HBG056057; -.
DR   InParanoid; P62910; -.
DR   KO; K02912; -.
DR   PhylomeDB; P62910; -.
DR   TreeFam; TF314947; -.
DR   BioCyc; ZFISH:ENSG00000144713-MONOMER; -.
DR   Reactome; R-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-HSA-156902; Peptide chain elongation.
DR   Reactome; R-HSA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-HSA-192823; Viral mRNA Translation.
DR   Reactome; R-HSA-2408557; Selenocysteine synthesis.
DR   Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-HSA-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-HSA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-HSA-72764; Eukaryotic Translation Termination.
DR   Reactome; R-HSA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   ChiTaRS; RPL32; human.
DR   GeneWiki; RPL32; -.
DR   GenomeRNAi; 6161; -.
DR   PRO; PR:P62910; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000144713; -.
DR   CleanEx; HS_RPL32; -.
DR   ExpressionAtlas; P62910; baseline and differential.
DR   Genevisible; P62910; HS.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
DR   GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR   GO; GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
DR   GO; GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
DR   GO; GO:0006364; P:rRNA processing; TAS:Reactome.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
DR   GO; GO:0006412; P:translation; NAS:UniProtKB.
DR   GO; GO:0006413; P:translational initiation; TAS:Reactome.
DR   GO; GO:0019083; P:viral transcription; TAS:Reactome.
DR   CDD; cd00513; Ribosomal_L32_L32e; 1.
DR   InterPro; IPR001515; Ribosomal_L32e.
DR   InterPro; IPR018263; Ribosomal_L32e_CS.
DR   Pfam; PF01655; Ribosomal_L32e; 1.
DR   ProDom; PD003823; Ribosomal_L32e; 1.
DR   SMART; SM01393; Ribosomal_L32e; 1.
DR   SUPFAM; SSF52042; SSF52042; 1.
DR   PROSITE; PS00580; RIBOSOMAL_L32E; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Direct protein sequencing;
KW   Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   INIT_MET      1      1       Removed. {ECO:0000269|Ref.7}.
FT   CHAIN         2    135       60S ribosomal protein L32.
FT                                /FTId=PRO_0000131113.
FT   MOD_RES      50     50       N6-succinyllysine.
FT                                {ECO:0000250|UniProtKB:P62911}.
FT   MOD_RES      62     62       Phosphoserine.
FT                                {ECO:0000244|PubMed:23186163}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        17    124       ismart:Ribosomal_L32e [T]
FT   MYHIT        20     40       ipat:RIBOSOMAL_L32E [T]
FT   MYHIT        17    124       ipfam:Ribosomal_L32e [T]
SQ   SEQUENCE   135 AA;  15860 MW;  EDEE48446483966E CRC64;
     MAALRPLVKP KIVKKRTKKF IRHQSDRYVK IKRNWRKPRG IDNRVRRRFK GQILMPNIGY
     GSNKKTKHML PSGFRKFLVH NVKELEVLLM CNKSYCAEIA HNVSSKNRKA IVERAAQLAI
     RVTNPNARLR SEENE
//