ID RCSB_ECOLX Reviewed; 216 AA.
AC P0DMC8; P14374; P69407;
DT 19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT 19-FEB-2014, sequence version 1.
DT 18-JAN-2017, entry version 23.
DE RecName: Full=Transcriptional regulatory protein RcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN Name=rcsB {ECO:0000255|HAMAP-Rule:MF_00981};
OS Escherichia coli.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN CAPSULAR
RP POLYSACCHARIDE SYNTHESIS.
RC STRAIN=O9:K30:H12;
RX PubMed=8366025;
RA Jayaratne P., Keenleyside W.J., Maclachlan P.R., Dodgson C.,
RA Whitfield C.;
RT "Characterization of rcsB and rcsC from Escherichia coli O9:K30:H12
RT and examination of the role of the rcs regulatory system in expression
RT of group I capsular polysaccharides.";
RL J. Bacteriol. 175:5384-5394(1993).
CC -!- FUNCTION: Component of the Rcs signaling system, which controls
CC transcription of numerous genes. RcsB is the response regulator
CC that binds to regulatory DNA regions. Can function both in an
CC RcsA-dependent or RcsA-independent manner (By similarity).
CC Involved in regulation of K30 capsular polysaccharide synthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00981, ECO:0000269|PubMed:8366025}.
CC -!- SUBUNIT: Interacts with RcsD and RcsA. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
CC -!- PTM: Phosphorylated and activated by RcsD. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
CC -!- SIMILARITY: Belongs to the RcsB family. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
CC -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.
CC {ECO:0000255|HAMAP-Rule:MF_00981}.
CC -!- SIMILARITY: Contains 1 response regulatory domain.
CC {ECO:0000255|PROSITE-ProRule:PRU00169}.
DR EMBL; L11272; AAA24506.1; -; Genomic_DNA.
DR PIR; JV0068; BVECCB.
DR RefSeq; WP_001061917.1; NZ_MLZI01000002.1.
DR ProteinModelPortal; P0DMC8; -.
DR SMR; P0DMC8; -.
DR STRING; 199310.c2760; -.
DR eggNOG; ENOG41068CG; Bacteria.
DR eggNOG; COG2197; LUCA.
DR OMA; IEWVNIV; -.
DR GO; GO:0005622; C:intracellular; IEA:GOC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR GO; GO:0004871; F:signal transducer activity; IEA:UniProtKB-HAMAP.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-HAMAP.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_00981; RcsB; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR030864; RcsB.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Phosphoprotein; Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1 216 Transcriptional regulatory protein RcsB.
FT /FTId=PRO_0000425416.
FT DOMAIN 5 124 Response regulatory.
FT {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT DOMAIN 144 209 HTH luxR-type. {ECO:0000255|HAMAP-
FT Rule:MF_00981}.
FT DNA_BIND 168 187 H-T-H motif. {ECO:0000255|HAMAP-
FT Rule:MF_00981}.
FT MOD_RES 56 56 4-aspartylphosphate. {ECO:0000255|HAMAP-
FT Rule:MF_00981}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 214 ihamap:RcsB [T]
FT MYHIT 165 192 ipat:HTH_LUXR_1 [T]
FT MYHIT 4 120 ismart:REC [T]
FT MYHIT 5 124 iprf:RESPONSE_REGULATORY [T]
FT MYHIT 144 209 iprf:HTH_LUXR_2 [T]
FT MYHIT 150 204 ipfam:GerE [T]
FT MYHIT 6 120 ipfam:Response_reg [T]
FT MYHIT 148 205 ismart:HTH_LUXR [T]
SQ SEQUENCE 216 AA; 23671 MW; A78D1BD3004E0680 CRC64;
MNNMNVIIAD DHPIVLFGIR KSLEQIEWVN VVGEFEDSTA LINNLPKLDA HVLITDLSMP
GDKYGDGITL IKYIKRHFPS LSIIVLTMNN NPAILSAVLD LDIEGIVLKQ GAPTDLPKAL
AALQKGKKFT PESVSRLLEK ISAGGYGDKR LSPKESEVLR LFAEGFLVTE IAKKLNRSIK
TISSQKKSAM MKLGVENDIA LLNYLSSVTL SPADKD
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