Entry sw:RCSB_ECO57

ID   RCSB_ECO57              Reviewed;         216 AA.
AC   P69409; P14374;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   02-NOV-2016, entry version 84.
DE   RecName: Full=Transcriptional regulatory protein RcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN   Name=rcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN   OrderedLocusNames=Z3476, ECs3106;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Component of the Rcs signaling system, which controls
CC       transcription of numerous genes. RcsB is the response regulator
CC       that binds to regulatory DNA regions. Can function both in an
CC       RcsA-dependent or RcsA-independent manner. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- SUBUNIT: Interacts with RcsD and RcsA. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- PTM: Phosphorylated and activated by RcsD. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- SIMILARITY: Belongs to the RcsB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.
CC       {ECO:0000255|HAMAP-Rule:MF_00981}.
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00169}.
DR   EMBL; AE005174; AAG57352.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36529.1; -; Genomic_DNA.
DR   PIR; B91017; B91017.
DR   RefSeq; NP_311133.1; NC_002695.1.
DR   RefSeq; WP_001061917.1; NZ_LPWC02000002.1.
DR   ProteinModelPortal; P69409; -.
DR   SMR; P69409; -.
DR   MINT; MINT-1221906; -.
DR   STRING; 155864.Z3476; -.
DR   PRIDE; P69409; -.
DR   EnsemblBacteria; AAG57352; AAG57352; Z3476.
DR   EnsemblBacteria; BAB36529; BAB36529; BAB36529.
DR   GeneID; 916814; -.
DR   KEGG; ece:Z3476; -.
DR   KEGG; ecs:ECs3106; -.
DR   PATRIC; 18355596; VBIEscCol44059_2999.
DR   eggNOG; ENOG41068CG; Bacteria.
DR   eggNOG; COG2197; LUCA.
DR   HOGENOM; HOG000034813; -.
DR   KO; K07687; -.
DR   OMA; IEWVNIV; -.
DR   BioCyc; ECOO157:RCSB-MONOMER; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004871; F:signal transducer activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00981; RcsB; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR030864; RcsB.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN         1    216       Transcriptional regulatory protein RcsB.
FT                                /FTId=PRO_0000081211.
FT   DOMAIN        5    124       Response regulatory.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT   DOMAIN      144    209       HTH luxR-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00981}.
FT   DNA_BIND    168    187       H-T-H motif. {ECO:0000255|HAMAP-
FT                                Rule:MF_00981}.
FT   MOD_RES      56     56       4-aspartylphosphate. {ECO:0000255|HAMAP-
FT                                Rule:MF_00981}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT         4    120       ismart:REC [T]
FT   MYHIT       165    192       ipat:HTH_LUXR_1 [T]
FT   MYHIT         5    124       iprf:RESPONSE_REGULATORY [T]
FT   MYHIT       148    205       ismart:HTH_LUXR [T]
FT   MYHIT         1    214       ihamap:RcsB [T]
FT   MYHIT       144    209       iprf:HTH_LUXR_2 [T]
FT   MYHIT       150    204       ipfam:GerE [T]
FT   MYHIT         6    120       ipfam:Response_reg [T]
SQ   SEQUENCE   216 AA;  23671 MW;  A78D1BD3004E0680 CRC64;
     MNNMNVIIAD DHPIVLFGIR KSLEQIEWVN VVGEFEDSTA LINNLPKLDA HVLITDLSMP
     GDKYGDGITL IKYIKRHFPS LSIIVLTMNN NPAILSAVLD LDIEGIVLKQ GAPTDLPKAL
     AALQKGKKFT PESVSRLLEK ISAGGYGDKR LSPKESEVLR LFAEGFLVTE IAKKLNRSIK
     TISSQKKSAM MKLGVENDIA LLNYLSSVTL SPADKD
//