ID RCSB_ECO57 Reviewed; 216 AA.
AC P69409; P14374;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 02-NOV-2016, entry version 84.
DE RecName: Full=Transcriptional regulatory protein RcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN Name=rcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN OrderedLocusNames=Z3476, ECs3106;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA Welch R.A., Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli
RT O157:H7 and genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Component of the Rcs signaling system, which controls
CC transcription of numerous genes. RcsB is the response regulator
CC that binds to regulatory DNA regions. Can function both in an
CC RcsA-dependent or RcsA-independent manner. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
CC -!- SUBUNIT: Interacts with RcsD and RcsA. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
CC -!- PTM: Phosphorylated and activated by RcsD. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
CC -!- SIMILARITY: Belongs to the RcsB family. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
CC -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.
CC {ECO:0000255|HAMAP-Rule:MF_00981}.
CC -!- SIMILARITY: Contains 1 response regulatory domain.
CC {ECO:0000255|PROSITE-ProRule:PRU00169}.
DR EMBL; AE005174; AAG57352.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB36529.1; -; Genomic_DNA.
DR PIR; B91017; B91017.
DR RefSeq; NP_311133.1; NC_002695.1.
DR RefSeq; WP_001061917.1; NZ_LPWC02000002.1.
DR ProteinModelPortal; P69409; -.
DR SMR; P69409; -.
DR MINT; MINT-1221906; -.
DR STRING; 155864.Z3476; -.
DR PRIDE; P69409; -.
DR EnsemblBacteria; AAG57352; AAG57352; Z3476.
DR EnsemblBacteria; BAB36529; BAB36529; BAB36529.
DR GeneID; 916814; -.
DR KEGG; ece:Z3476; -.
DR KEGG; ecs:ECs3106; -.
DR PATRIC; 18355596; VBIEscCol44059_2999.
DR eggNOG; ENOG41068CG; Bacteria.
DR eggNOG; COG2197; LUCA.
DR HOGENOM; HOG000034813; -.
DR KO; K07687; -.
DR OMA; IEWVNIV; -.
DR BioCyc; ECOO157:RCSB-MONOMER; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0005622; C:intracellular; IEA:GOC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR GO; GO:0004871; F:signal transducer activity; IEA:UniProtKB-HAMAP.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-HAMAP.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_00981; RcsB; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR030864; RcsB.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Complete proteome; DNA-binding; Phosphoprotein; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1 216 Transcriptional regulatory protein RcsB.
FT /FTId=PRO_0000081211.
FT DOMAIN 5 124 Response regulatory.
FT {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT DOMAIN 144 209 HTH luxR-type. {ECO:0000255|HAMAP-
FT Rule:MF_00981}.
FT DNA_BIND 168 187 H-T-H motif. {ECO:0000255|HAMAP-
FT Rule:MF_00981}.
FT MOD_RES 56 56 4-aspartylphosphate. {ECO:0000255|HAMAP-
FT Rule:MF_00981}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 6 120 ipfam:Response_reg [T]
FT MYHIT 165 192 ipat:HTH_LUXR_1 [T]
FT MYHIT 5 124 iprf:RESPONSE_REGULATORY [T]
FT MYHIT 150 204 ipfam:GerE [T]
FT MYHIT 148 205 ismart:HTH_LUXR [T]
FT MYHIT 1 214 ihamap:RcsB [T]
FT MYHIT 4 120 ismart:REC [T]
FT MYHIT 144 209 iprf:HTH_LUXR_2 [T]
SQ SEQUENCE 216 AA; 23671 MW; A78D1BD3004E0680 CRC64;
MNNMNVIIAD DHPIVLFGIR KSLEQIEWVN VVGEFEDSTA LINNLPKLDA HVLITDLSMP
GDKYGDGITL IKYIKRHFPS LSIIVLTMNN NPAILSAVLD LDIEGIVLKQ GAPTDLPKAL
AALQKGKKFT PESVSRLLEK ISAGGYGDKR LSPKESEVLR LFAEGFLVTE IAKKLNRSIK
TISSQKKSAM MKLGVENDIA LLNYLSSVTL SPADKD
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