Legends: 1, N-linked (GlcNAc...). {ECO:0000255}; 2, VARIANT F -> V (in dbSNP:rs17438900); 3, VARIANT H -> Q (in dbSNP:rs11947418); 4, VARIANT L -> S (in dbSNP:rs2302310); 5, TOPO_DOM Extracellular. {ECO:0000255}; 6, TRANSMEM Helical; Name=1. {ECO:0000255}; 7, TOPO_DOM Cytoplasmic. {ECO:0000255}; 8, TRANSMEM Helical; Name=2. {ECO:0000255}; 9, TRANSMEM Helical; Name=3. {ECO:0000255}; 10, TRANSMEM Helical; Name=4. {ECO:0000255}; 11, TRANSMEM Helical; Name=5. {ECO:0000255}; 12, TRANSMEM Helical; Name=6. {ECO:0000255}; 13, TRANSMEM Helical; Name=7. {ECO:0000255}; 14, CONFLICT LY -> VH (in Ref. 3; BAC98938). {ECO:0000305}; 15, CONFLICT VILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKE MSKIAR -> SSSSSCLLW (in Ref. 1; AAL26488). {ECO:0000305}; 16, ipat:G_PROTEIN_RECEP_F1_1 [T].
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ID QRFPR_HUMAN Reviewed; 431 AA.
AC Q96P65;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 02-NOV-2016, entry version 125.
DE RecName: Full=Pyroglutamylated RFamide peptide receptor;
DE AltName: Full=AQ27;
DE AltName: Full=G-protein coupled receptor 103;
DE AltName: Full=Orexigenic neuropeptide QRFP receptor;
DE AltName: Full=SP9155;
GN Name=QRFPR; Synonyms=GPR103;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11574155; DOI=10.1016/S0378-1119(01)00651-5;
RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O.,
RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.;
RT "Discovery and mapping of ten novel G protein-coupled receptor
RT genes.";
RL Gene 275:83-91(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12714592; DOI=10.1074/jbc.M302945200;
RA Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N.,
RA Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S.,
RA Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.;
RT "Identification and characterization of a novel RF-amide peptide
RT ligand for orphan G-protein-coupled receptor SP9155.";
RL J. Biol. Chem. 278:27652-27657(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC TISSUE=Fetal brain;
RX PubMed=12960173; DOI=10.1074/jbc.M305270200;
RA Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y.,
RA Shintani Y., Hinuma S., Fujino M.;
RT "A new peptidic ligand and its receptor regulating adrenal function in
RT rats.";
RL J. Biol. Chem. 278:46387-46395(2003).
CC -!- FUNCTION: Receptor for the orexigenic neuropeptide QRFP. The
CC activity of this receptor is mediated by G proteins that modulate
CC adenylate cyclase activity and intracellular calcium levels.
CC {ECO:0000269|PubMed:12960173}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed widely in the brain with high levels
CC in the hypothalamus, trigeminal ganglia and vestibular neurons,
CC and moderate levels in the amygdala, cortex, pituitary,
CC hippocampus, thalamus, caudate nucleus and medulla oblongata. In
CC peripheral tissues, expressed at high levels in the retina and at
CC moderate levels in the heart, kidney, testis and thyroid.
CC {ECO:0000269|PubMed:11574155, ECO:0000269|PubMed:12714592}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL26488.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR EMBL; AF411117; AAL26488.1; ALT_INIT; mRNA.
DR EMBL; AB109629; BAC98938.1; -; mRNA.
DR CCDS; CCDS3719.1; -.
DR RefSeq; NP_937822.2; NM_198179.2.
DR UniGene; Hs.368977; -.
DR ProteinModelPortal; Q96P65; -.
DR BioGrid; 123897; 1.
DR STRING; 9606.ENSP00000377948; -.
DR BindingDB; Q96P65; -.
DR ChEMBL; CHEMBL5852; -.
DR GuidetoPHARMACOLOGY; 333; -.
DR iPTMnet; Q96P65; -.
DR PhosphoSitePlus; Q96P65; -.
DR BioMuta; QRFPR; -.
DR DMDM; 47117904; -.
DR EPD; Q96P65; -.
DR PaxDb; Q96P65; -.
DR PeptideAtlas; Q96P65; -.
DR PRIDE; Q96P65; -.
DR DNASU; 84109; -.
DR Ensembl; ENST00000394427; ENSP00000377948; ENSG00000186867.
DR GeneID; 84109; -.
DR KEGG; hsa:84109; -.
DR UCSC; uc010inj.2; human.
DR CTD; 84109; -.
DR GeneCards; QRFPR; -.
DR H-InvDB; HIX0031352; -.
DR HGNC; HGNC:15565; QRFPR.
DR HPA; HPA014300; -.
DR MIM; 606925; gene.
DR neXtProt; NX_Q96P65; -.
DR OpenTargets; ENSG00000186867; -.
DR PharmGKB; PA164725243; -.
DR eggNOG; KOG3656; Eukaryota.
DR eggNOG; ENOG410XRW9; LUCA.
DR GeneTree; ENSGT00760000118781; -.
DR HOGENOM; HOG000136537; -.
DR HOVERGEN; HBG067831; -.
DR InParanoid; Q96P65; -.
DR KO; K08378; -.
DR OMA; GNALVFY; -.
DR OrthoDB; EOG091G0976; -.
DR PhylomeDB; Q96P65; -.
DR TreeFam; TF315303; -.
DR BioCyc; ZFISH:G66-30828-MONOMER; -.
DR Reactome; R-HSA-389397; Orexin and neuropeptides FF and QRFP bind to their respective receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR GeneWiki; Pyroglutamylated_RFamide_peptide_receptor; -.
DR GenomeRNAi; 84109; -.
DR PRO; PR:Q96P65; -.
DR Proteomes; UP000005640; Chromosome 4.
DR Bgee; ENSG00000186867; -.
DR CleanEx; HS_QRFPR; -.
DR ExpressionAtlas; Q96P65; baseline and differential.
DR Genevisible; Q96P65; HS.
DR GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IDA:UniProtKB.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:1901652; P:response to peptide; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; G-protein coupled receptor;
KW Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 431 Pyroglutamylated RFamide peptide
FT receptor.
FT /FTId=PRO_0000070097.
FT TOPO_DOM 1 46 Extracellular. {ECO:0000255}.
FT TRANSMEM 47 67 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 68 81 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 82 102 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 103 120 Extracellular. {ECO:0000255}.
FT TRANSMEM 121 141 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 142 162 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 163 183 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 184 212 Extracellular. {ECO:0000255}.
FT TRANSMEM 213 233 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 234 271 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 272 292 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 293 311 Extracellular. {ECO:0000255}.
FT TRANSMEM 312 332 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 333 431 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 19 19 N-linked (GlcNAc...). {ECO:0000255}.
FT VARIANT 61 61 F -> V (in dbSNP:rs17438900).
FT /FTId=VAR_049437.
FT VARIANT 149 149 H -> Q (in dbSNP:rs11947418).
FT /FTId=VAR_049438.
FT VARIANT 344 344 L -> S (in dbSNP:rs2302310).
FT /FTId=VAR_049439.
FT CONFLICT 28 29 LY -> VH (in Ref. 3; BAC98938).
FT {ECO:0000305}.
FT CONFLICT 220 266 VILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKE
FT MSKIAR -> SSSSSCLLW (in Ref. 1;
FT AAL26488). {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 62 332 ipfam:7tm_1 [T]
FT MYHIT 131 147 ipat:G_PROTEIN_RECEP_F1_1 [T]
FT MYHIT 62 332 iprf:G_PROTEIN_RECEP_F1_2 [T]
SQ SEQUENCE 431 AA; 49488 MW; 778D9AE70528024D CRC64;
MQALNITPEQ FSRLLRDHNL TREQFIALYR LRPLVYTPEL PGRAKLALVL TGVLIFALAL
FGNALVFYVV TRSKAMRTVT NIFICSLALS DLLITFFCIP VTMLQNISDN WLGGAFICKM
VPFVQSTAVV TEILTMTCIA VERHQGLVHP FKMKWQYTNR RAFTMLGVVW LVAVIVGSPM
WHVQQLEIKY DFLYEKEHIC CLEEWTSPVH QKIYTTFILV ILFLLPLMVM LILYSKIGYE
LWIKKRVGDG SVLRTIHGKE MSKIARKKKR AVIMMVTVVA LFAVCWAPFH VVHMMIEYSN
FEKEYDDVTI KMIFAIVQII GFSNSICNPI VYAFMNENFK KNVLSAVCYC IVNKTFSPAQ
RHGNSGITMM RKKAKFSLRE NPVEETKGEA FSDGNIEVKL CEQTEEKKKL KRHLALFRSE
LAENSPLDSG H
//
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