ID PYRB_PSYWF Reviewed; 362 AA.
AC A5WGK5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 02-NOV-2016, entry version 56.
DE RecName: Full=Aspartate carbamoyltransferase {ECO:0000255|HAMAP-Rule:MF_00001};
DE EC=2.1.3.2 {ECO:0000255|HAMAP-Rule:MF_00001};
DE AltName: Full=Aspartate transcarbamylase {ECO:0000255|HAMAP-Rule:MF_00001};
DE Short=ATCase {ECO:0000255|HAMAP-Rule:MF_00001};
GN Name=pyrB {ECO:0000255|HAMAP-Rule:MF_00001};
GN OrderedLocusNames=PsycPRwf_1856;
OS Psychrobacter sp. (strain PRwf-1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Moraxellaceae; Psychrobacter.
OX NCBI_TaxID=349106;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PRwf-1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J.,
RA Richardson P.;
RT "Complete sequence of chromosome of Psychrobacter sp. PRwf-1.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC + N-carbamoyl-L-aspartate. {ECO:0000255|HAMAP-Rule:MF_00001}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
CC {ECO:0000255|HAMAP-Rule:MF_00001}.
CC -!- SIMILARITY: Belongs to the ATCase/OTCase family.
CC {ECO:0000255|HAMAP-Rule:MF_00001}.
DR EMBL; CP000713; ABQ94796.1; -; Genomic_DNA.
DR ProteinModelPortal; A5WGK5; -.
DR STRING; 349106.PsycPRwf_1856; -.
DR EnsemblBacteria; ABQ94796; ABQ94796; PsycPRwf_1856.
DR KEGG; prw:PsycPRwf_1856; -.
DR eggNOG; ENOG4105CXT; Bacteria.
DR eggNOG; COG0540; LUCA.
DR HOGENOM; HOG000022685; -.
DR KO; K00609; -.
DR OMA; MHPGPMV; -.
DR OrthoDB; POG091H00PQ; -.
DR UniPathway; UPA00070; UER00116.
DR Proteomes; UP000001993; Chromosome.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-HAMAP.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1370; -; 2.
DR HAMAP; MF_00001; Asp_carb_tr; 1.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR002082; Asp_carbamoyltransf.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00101; ATCASE.
DR SUPFAM; SSF53671; SSF53671; 1.
DR TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 3: Inferred from homology;
KW Complete proteome; Pyrimidine biosynthesis; Reference proteome;
KW Transferase.
FT CHAIN 1 362 Aspartate carbamoyltransferase.
FT /FTId=PRO_0000329115.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 48 351 ihamap:Asp_carb_tr [T]
FT MYHIT 94 101 ipat:CARBAMOYLTRANSFERASE [T]
FT MYHIT 201 346 ipfam:OTCace [T]
FT MYHIT 49 192 ipfam:OTCace_N [T]
SQ SEQUENCE 362 AA; 39492 MW; 9542D0C3FB4DED7C CRC64;
MPKTAMTDST SKTSTNTASS DMAAEFDSTT ARLNASLSKP QLNADGHLRH FLGIEGLSRA
QLLAIIHKAE SFFDDKGQLI NSPELEGCTV MNLFFEPSTR TRTTFEVAEK RLGANVLNID
IARSSTQKGE SLRDTLWNLQ AMTADIFVVR HSASGAAHFM ATEVTPDIAI INGGDGWHAH
PTQAMLDMLT IHREAPRPFE ELTVAIIGDI KHSRVARSDI AALKILGVKE IRVIAPRTLL
PKGIERYGVK VFENIDEGVV DCDVLMGLRI QNERIGSPLM AASNEYFKKY GITPERVAKA
KPDALVMHPG PMNRGVEIAS SVADGPQSVI LKQVNNGIAV RMAVLSMAMQ GQREYQALRS
ST
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