MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Putative tRNA pseudouridine synthase Pus10; EC=5.4.99.-; AltName: Full=Coiled-coil domain-containing protein 139; AltName: Full=tRNA pseudouridine 55 synthase; Short=Psi55 synthase; AltName: Full=tRNA pseudouridylate synthase; AltName: Full=tRNA-uridine isomerase; |
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| MyHits synonyms | PUS10_XENLA , Q6ING2 , 51F63C0767E0DF04 |
 Legends: 1, ACT_SITE Nucleophile. {ECO:0000255}; 2, BINDING Substrate. {ECO:0000255}; 3, REGION RNA binding forefinger loop. {ECO:0000255}; 4, REGION RNA binding thumb loop. {ECO:0000255}; 5, COILED {ECO:0000255}.
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ID PUS10_XENLA Reviewed; 515 AA.
AC Q6ING2;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 18-JAN-2017, entry version 39.
DE RecName: Full=Putative tRNA pseudouridine synthase Pus10;
DE EC=5.4.99.-;
DE AltName: Full=Coiled-coil domain-containing protein 139;
DE AltName: Full=tRNA pseudouridine 55 synthase;
DE Short=Psi55 synthase;
DE AltName: Full=tRNA pseudouridylate synthase;
DE AltName: Full=tRNA-uridine isomerase;
GN Name=pus10; Synonyms=ccdc139;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC 55 in the psi GC loop of transfer RNAs. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY: tRNA uridine = tRNA pseudouridine.
CC -!- SIMILARITY: Belongs to the pseudouridine synthase Pus10 family.
CC {ECO:0000305}.
DR EMBL; BC072319; AAH72319.1; -; mRNA.
DR RefSeq; NP_001085415.1; NM_001091946.1.
DR UniGene; Xl.14115; -.
DR ProteinModelPortal; Q6ING2; -.
DR GeneID; 443841; -.
DR KEGG; xla:443841; -.
DR CTD; 443841; -.
DR Xenbase; XB-GENE-5903783; pus10.
DR HOVERGEN; HBG056180; -.
DR KO; K07583; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR SUPFAM; SSF55120; SSF55120; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Isomerase; tRNA processing.
FT CHAIN 1 515 Putative tRNA pseudouridine synthase
FT Pus10.
FT /FTId=PRO_0000299024.
FT REGION 291 304 RNA binding forefinger loop.
FT {ECO:0000255}.
FT REGION 428 443 RNA binding thumb loop. {ECO:0000255}.
FT COILED 42 85 {ECO:0000255}.
FT ACT_SITE 331 331 Nucleophile. {ECO:0000255}.
FT BINDING 400 400 Substrate. {ECO:0000255}.
FT BINDING 471 471 Substrate. {ECO:0000255}.
SQ SEQUENCE 515 AA; 58590 MW; 51F63C0767E0DF04 CRC64;
MLLIEEKYRS VAQVLLSSGT CSRCVLRFCC VGSPANYRLP CKEVTYELQK YLSHGDPAEE
NDTPPSKKAK IEEDTSSNEH LGNCEDVNGS QVVRICPLCL GILQQFCEPE FIEKVFVKIN
SAVYELKDFV LSISLPAQLS VREHSAWLQA KQEMGKHGHS LDKTDIVQLK EAYKWIIHPL
LSDQLGIQAD SKSLFEVAVV FTHPETDGDC HFLATVCRDC FKPTKNKQSV FTRMAVVKAL
EKIKEEDFRV QFPFPPSSPE TTCEVVDIQC NHSPVFVAGR YNKYSRNLPQ TPWIIDGERK
IESSVEELIT DHLVAAFRSS SFNFSSSGRE DVDVRTLGKG RPFAIELLNP HKVQFTGQEI
KALQQKINTS DKIKVRDLQI VSREAVAHMK EGEEEKTKCY CALIWIEKMV RNEDLQLLDG
LEELTIAQKT PLRVLHRRPL ASRSRTIHTM RTEYVDEHHF RLYLKTQAGT YIKEFVHGDF
GRTKPNVGSI METNADILEL DVESVDVDWP PSLDD
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