MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=PTS system glucitol/sorbitol-specific EIIC component {ECO:0000250|UniProtKB:P56579}; AltName: Full=EIIC-Gut {ECO:0000250|UniProtKB:P56579}; AltName: Full=Glucitol/sorbitol permease IIC component {ECO:0000250|UniProtKB:P56579}; |
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| MyHits synonyms | PTHC_ERWAM , O32521 , FC372C4312ABCE39 |
 Legends: 1, TRANSMEM Helical. {ECO:0000255|PROSITE- ProRule:PRU00430}.
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ID PTHC_ERWAM Reviewed; 182 AA.
AC O32521;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 02-NOV-2016, entry version 70.
DE RecName: Full=PTS system glucitol/sorbitol-specific EIIC component {ECO:0000250|UniProtKB:P56579};
DE AltName: Full=EIIC-Gut {ECO:0000250|UniProtKB:P56579};
DE AltName: Full=Glucitol/sorbitol permease IIC component {ECO:0000250|UniProtKB:P56579};
GN Name=srlA;
OS Erwinia amylovora (Fire blight bacteria).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Erwinia.
OX NCBI_TaxID=552;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC STRAIN=EA7/74;
RX PubMed=9435786; DOI=10.1007/s004380050609;
RA Aldridge P., Metzger M., Geider K.;
RT "Genetics of sorbitol metabolism in Erwinia amylovora and its
RT influence on bacterial virulence.";
RL Mol. Gen. Genet. 256:611-619(1997).
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar
CC phosphotransferase system (PTS), a major carbohydrate active
CC transport system, catalyzes the phosphorylation of incoming sugar
CC substrates concomitant with their translocation across the cell
CC membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is
CC involved in glucitol/sorbitol transport.
CC {ECO:0000305|PubMed:9435786}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00430}; Multi-pass membrane protein
CC {ECO:0000255|PROSITE-ProRule:PRU00430}.
CC -!- INDUCTION: Activated by sorbitol and repressed by glucose.
CC {ECO:0000269|PubMed:9435786}.
CC -!- DOMAIN: The EIIC domain forms the PTS system translocation channel
CC and contains the specific substrate-binding site.
CC {ECO:0000255|PROSITE-ProRule:PRU00430}.
CC -!- SIMILARITY: Contains 1 PTS EIIC type-5 domain.
CC {ECO:0000255|PROSITE-ProRule:PRU00430}.
DR EMBL; Y14603; CAA74941.1; -; Genomic_DNA.
DR ProteinModelPortal; O32521; -.
DR SMR; O32521; -.
DR STRING; 665029.EAMY_3076; -.
DR GeneID; 8914017; -.
DR eggNOG; ENOG410787A; Bacteria.
DR eggNOG; COG3730; LUCA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR InterPro; IPR004699; PTS_IID_sorb.
DR Pfam; PF03608; EII-GUT; 1.
DR PIRSF; PIRSF038321; PTS_glc_srb_IIC; 1.
DR TIGRFAMs; TIGR00821; EII-GUT; 1.
DR PROSITE; PS51107; PTS_EIIC_TYPE_5; 1.
PE 2: Evidence at transcript level;
KW Cell inner membrane; Cell membrane; Membrane;
KW Phosphotransferase system; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 182 PTS system glucitol/sorbitol-specific
FT EIIC component.
FT /FTId=PRO_0000186566.
FT TRANSMEM 29 49 Helical. {ECO:0000255|PROSITE-
FT ProRule:PRU00430}.
FT TRANSMEM 68 88 Helical. {ECO:0000255|PROSITE-
FT ProRule:PRU00430}.
FT TRANSMEM 132 152 Helical. {ECO:0000255|PROSITE-
FT ProRule:PRU00430}.
FT DOMAIN 1 182 PTS EIIC type-5. {ECO:0000255|PROSITE-
FT ProRule:PRU00430}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 182 iprf:PTS_EIIC_TYPE_5 [T]
FT MYHIT 5 171 ipfam:EII-GUT [T]
SQ SEQUENCE 182 AA; 20000 MW; FC372C4312ABCE39 CRC64;
MIEAITHGAE WFIGLFQKGG EVFVGMVTGI LPLLISLLVI MNALIVFVGQ RRIEKLAQKC
AGNPVTRYLV LPFIGTFVFC NPMTHSLGKF LPEKYKPSYY AAASYSCHSM NGLFPHINPG
ELFVYLGIAN GLTTLGVPLG PLAVSYLLVG LITNFFRGWV TDLTTSVFEK KMGIKLDKSV
HL
//
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