Entry sw:PTHC_CLOB8

ID   PTHC_CLOB8              Reviewed;         182 AA.
AC   O32332; A6LQ94;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   02-NOV-2016, entry version 95.
DE   RecName: Full=PTS system glucitol/sorbitol-specific EIIC component {ECO:0000250|UniProtKB:P56579};
DE   AltName: Full=EIIC-Gut {ECO:0000250|UniProtKB:P56579};
DE   AltName: Full=Glucitol/sorbitol permease IIC component {ECO:0000250|UniProtKB:P56579};
GN   Name=srlA; Synonyms=gutA1; OrderedLocusNames=Cbei_0336;
OS   Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium
OS   acetobutylicum).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=290402;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RX   PubMed=9572925;
RA   Tangney M., Brehm J.K., Minton N.P., Mitchell W.J.;
RT   "A gene system for glucitol transport and metabolism in Clostridium
RT   beijerinckii NCIMB 8052.";
RL   Appl. Environ. Microbiol. 64:1612-1619(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51743 / NCIMB 8052;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Tapia R., Brainard J.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Bennet G., Cann I., Chen J.-S., Contreras A.L.,
RA   Jones D., Kashket E., Mitchell W., Stoddard S., Schwarz W.,
RA   Qureshi N., Young M., Shi Z., Ezeji T., White B., Blaschek H.,
RA   Richardson P.;
RT   "Complete sequence of Clostridium beijerinckii NCIMB 8052.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The phosphoenolpyruvate-dependent sugar
CC       phosphotransferase system (PTS), a major carbohydrate active
CC       transport system, catalyzes the phosphorylation of incoming sugar
CC       substrates concomitant with their translocation across the cell
CC       membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is
CC       involved in glucitol/sorbitol transport.
CC       {ECO:0000305|PubMed:9572925}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00430}; Multi-pass membrane protein
CC       {ECO:0000255|PROSITE-ProRule:PRU00430}.
CC   -!- INDUCTION: Activated by sorbitol and repressed by glucose.
CC       {ECO:0000269|PubMed:9572925}.
CC   -!- DOMAIN: The EIIC domain forms the PTS system translocation channel
CC       and contains the specific substrate-binding site.
CC       {ECO:0000255|PROSITE-ProRule:PRU00430}.
CC   -!- SIMILARITY: Contains 1 PTS EIIC type-5 domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00430}.
DR   EMBL; AJ002527; CAA05513.1; -; Genomic_DNA.
DR   EMBL; CP000721; ABR32524.1; -; Genomic_DNA.
DR   RefSeq; WP_011967685.1; NC_009617.1.
DR   ProteinModelPortal; O32332; -.
DR   STRING; 290402.Cbei_0336; -.
DR   TCDB; 4.A.4.1.2; the pts glucitol (gut) family.
DR   EnsemblBacteria; ABR32524; ABR32524; Cbei_0336.
DR   KEGG; cbe:Cbei_0336; -.
DR   PATRIC; 19344526; VBICloBei69853_0346.
DR   eggNOG; ENOG410787A; Bacteria.
DR   eggNOG; COG3730; LUCA.
DR   HOGENOM; HOG000242767; -.
DR   KO; K02783; -.
DR   OMA; HINPGEY; -.
DR   OrthoDB; POG091H0R8F; -.
DR   Proteomes; UP000000565; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   InterPro; IPR004699; PTS_IID_sorb.
DR   Pfam; PF03608; EII-GUT; 1.
DR   PIRSF; PIRSF038321; PTS_glc_srb_IIC; 1.
DR   TIGRFAMs; TIGR00821; EII-GUT; 1.
DR   PROSITE; PS51107; PTS_EIIC_TYPE_5; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Membrane; Phosphotransferase system;
KW   Reference proteome; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    182       PTS system glucitol/sorbitol-specific
FT                                EIIC component.
FT                                /FTId=PRO_0000186567.
FT   TRANSMEM     28     48       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00430}.
FT   TRANSMEM     63     83       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00430}.
FT   TRANSMEM    139    159       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00430}.
FT   DOMAIN        1    182       PTS EIIC type-5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00430}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT         4    170       ipfam:EII-GUT [T]
FT   MYHIT         1    182       iprf:PTS_EIIC_TYPE_5 [T]
SQ   SEQUENCE   182 AA;  20185 MW;  58EBE4D822677154 CRC64;
     MDAIVYFAKG FMYLFEVGGN TFVSWVTGII PKVLLLLVFM NSIIAFIGQD KVDRFAKFAS
     RNVILAYGVL PFLSAFMLGN PMALSMGKFL PERMKPSYYA SASYHCHTNS GIFPHINVGE
     IFIYLGIANG ITTLGLDPTA LGLRYLLVGL VMNFFAGWVT DFTTKIVMRQ QGIELSNQLK
     AN
//