ID PRE2_ARATH Reviewed; 94 AA.
AC Q9LXG5;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 30-NOV-2016, entry version 108.
DE RecName: Full=Transcription factor PRE2;
DE AltName: Full=Basic helix-loop-helix protein 134;
DE Short=AtbHLH134;
DE Short=bHLH 134;
DE AltName: Full=Protein BANQUO 2;
DE AltName: Full=Protein PACLOBUTRAZOL RESISTANCE 2;
DE AltName: Full=bHLH transcription factor bHLH134;
GN Name=PRE2; Synonyms=BHLH134, BNQ2; OrderedLocusNames=At5g15160;
GN ORFNames=F8M21.50;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
RA Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
RA Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
RA Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
RA Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
RA Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
RA Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
RA Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
RA Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
RA Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
RA Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
RA Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
RA Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
RA Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
RA van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
RA Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
RA Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
RA Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis
RT thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RG The Arabidopsis Information Resource (TAIR);
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
RA Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
RA Shibata K., Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=16527868; DOI=10.1093/pcp/pcj026;
RA Lee S., Lee S., Yang K.Y., Kim Y.M., Park S.Y., Kim S.Y., Soh M.S.;
RT "Overexpression of PRE1 and its homologous genes activates
RT gibberellin-dependent responses in Arabidopsis thaliana.";
RL Plant Cell Physiol. 47:591-600(2006).
RN [6]
RP FUNCTION, AND INTERACTION WITH HFR1.
RX PubMed=20305124; DOI=10.1105/tpc.109.065946;
RA Mara C.D., Huang T., Irish V.F.;
RT "The Arabidopsis floral homeotic proteins APETALA3 and PISTILLATA
RT negatively regulate the BANQUO genes implicated in light signaling.";
RL Plant Cell 22:690-702(2010).
CC -!- FUNCTION: Atypical and probable non DNA-binding bHLH transcription
CC factor that integrates multiple signaling pathways to regulate
CC cell elongation and plant development. Regulates light responses
CC by binding and inhibiting the activity of the bHLH transcription
CC factor HFR1, a critical regulator of light signaling and shade
CC avoidance. May have a regulatory role in various aspects of
CC gibberellin-dependent growth and development.
CC {ECO:0000269|PubMed:16527868, ECO:0000269|PubMed:20305124}.
CC -!- SUBUNIT: Interacts with HFR1. {ECO:0000269|PubMed:20305124}.
CC -!- INTERACTION:
CC Q9C8Z9:BHLH148; NbExp=3; IntAct=EBI-4459591, EBI-4434374;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC {ECO:0000269|PubMed:16527868}.
CC -!- INDUCTION: Not induced by exogenous gibberellin.
CC {ECO:0000269|PubMed:16527868}.
CC -!- MISCELLANEOUS: Plants over-expressing PRE2 show long hypocotyls,
CC pale green and slightly narrow leaves, elongated petioles and
CC early flowering. They are not sensitive to the gibberellin
CC inhibitor paclobutrazol during seed germination (PubMed:16527868).
CC {ECO:0000305|PubMed:16527868}.
CC -!- SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
CC {ECO:0000255|PROSITE-ProRule:PRU00981}.
DR EMBL; AL353993; CAB89326.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92123.1; -; Genomic_DNA.
DR EMBL; AK118887; BAC43472.1; -; mRNA.
DR EMBL; BT005460; AAO63880.1; -; mRNA.
DR PIR; T49951; T49951.
DR RefSeq; NP_197020.1; NM_121520.4.
DR UniGene; At.1763; -.
DR ProteinModelPortal; Q9LXG5; -.
DR BioGrid; 16645; 1.
DR IntAct; Q9LXG5; 1.
DR STRING; 3702.AT5G15160.1; -.
DR iPTMnet; Q9LXG5; -.
DR PaxDb; Q9LXG5; -.
DR EnsemblPlants; AT5G15160.1; AT5G15160.1; AT5G15160.
DR GeneID; 831368; -.
DR Gramene; AT5G15160.1; AT5G15160.1; AT5G15160.
DR KEGG; ath:AT5G15160; -.
DR TAIR; AT5G15160; -.
DR eggNOG; ENOG410JV97; Eukaryota.
DR eggNOG; ENOG411064B; LUCA.
DR HOGENOM; HOG000239487; -.
DR InParanoid; Q9LXG5; -.
DR OMA; NRRSNKA; -.
DR OrthoDB; EOG09360Z6Z; -.
DR PhylomeDB; Q9LXG5; -.
DR PRO; PR:Q9LXG5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR Genevisible; Q9LXG5; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005773; C:vacuole; IDA:TAIR.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISS:TAIR.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009640; P:photomorphogenesis; IMP:TAIR.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR GO; GO:0048510; P:regulation of timing of transition from vegetative to reproductive phase; IMP:TAIR.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR Pfam; PF00010; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Gibberellin signaling pathway; Growth regulation;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1 94 Transcription factor PRE2.
FT /FTId=PRO_0000429084.
FT DOMAIN 5 60 bHLH. {ECO:0000255|PROSITE-
FT ProRule:PRU00981}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 5 60 iprf:BHLH [T]
FT MYHIT 19 60 ipfam:HLH [T]
SQ SEQUENCE 94 AA; 10546 MW; DCE5E5CF011B4EC3 CRC64;
MSSSRRSRQA SSSSRISDDQ ITDLISKLRQ SIPEIRQNRR SNTVSASKVL QETCNYIRNL
NKEADDLSDR LTQLLESIDP NSPQAAVIRS LING
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