ID PR46B_CHLRE Reviewed; 267 AA.
AC Q94EY1;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 11-MAY-2016, entry version 46.
DE RecName: Full=Coiled-coil domain-containing protein 103 homolog;
DE AltName: Full=Protein PR46bp;
GN Name=PR46b; ORFNames=CHLREDRAFT_24002;
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; Chlorophyceae;
OC Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CC-620;
RX PubMed=11805055;
RA Ferris P.J., Armbrust E.V., Goodenough U.W.;
RT "Genetic structure of the mating-type locus of Chlamydomonas
RT reinhardtii.";
RL Genetics 160:181-200(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CC-503;
RA Ferris P., Olson B.J., De Hoff P.L., Douglass S., Casero D.,
RA Prochnik S., Geng S., Rai R., Grimwood J., Schmutz J., Nishii I.,
RA Hamaji T., Nozaki H., Pellegrini M., Umen J.G.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K.,
RA Marechal-Drouard L., Marshall W.F., Qu L.H., Nelson D.R.,
RA Sanderfoot A.A., Spalding M.H., Kapitonov V.V., Ren Q., Ferris P.,
RA Lindquist E., Shapiro H., Lucas S.M., Grimwood J., Schmutz J.,
RA Cardol P., Cerutti H., Chanfreau G., Chen C.L., Cognat V., Croft M.T.,
RA Dent R., Dutcher S., Fernandez E., Fukuzawa H., Gonzalez-Ballester D.,
RA Gonzalez-Halphen D., Hallmann A., Hanikenne M., Hippler M., Inwood W.,
RA Jabbari K., Kalanon M., Kuras R., Lefebvre P.A., Lemaire S.D.,
RA Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L., Mittag M.,
RA Mittelmeier T., Moroney J.V., Moseley J., Napoli C., Nedelcu A.M.,
RA Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J., Purton S.,
RA Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L., Schroda M.,
RA Stern D., Umen J., Willows R., Wilson N., Zimmer S.L., Allmer J.,
RA Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P.,
RA Jorgensen R., Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T.,
RA Brokstein P., Dubchak I., Goodstein D., Hornick L., Huang Y.W.,
RA Jhaveri J., Luo Y., Martinez D., Ngau W.C., Otillar B., Poliakov A.,
RA Porter A., Szajkowski L., Werner G., Zhou K., Grigoriev I.V.,
RA Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and
RT plant functions.";
RL Science 318:245-250(2007).
RN [4]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=22581229; DOI=10.1038/ng.2277;
RA Panizzi J.R., Becker-Heck A., Castleman V.H., Al-Mutairi D.A., Liu Y.,
RA Loges N.T., Pathak N., Austin-Tse C., Sheridan E., Schmidts M.,
RA Olbrich H., Werner C., Haffner K., Hellman N., Chodhari R., Gupta A.,
RA Kramer-Zucker A., Olale F., Burdine R.D., Schier A.F., O'Callaghan C.,
RA Chung E.M., Reinhardt R., Mitchison H.M., King S.M., Omran H.,
RA Drummond I.A.;
RT "CCDC103 mutations cause primary ciliary dyskinesia by disrupting
RT assembly of ciliary dynein arms.";
RL Nat. Genet. 44:714-719(2012).
CC -!- FUNCTION: Dynein-attachment factor required for cilia motility.
CC {ECO:0000269|PubMed:22581229}.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:22581229}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22581229}.
CC Cell projection, cilium, flagellum {ECO:0000269|PubMed:22581229}.
CC -!- SIMILARITY: Belongs to the CCDC103/PR46b family. {ECO:0000305}.
DR EMBL; AF387366; AAK70875.1; -; Genomic_DNA.
DR EMBL; GU814014; ADF43150.1; -; Genomic_DNA.
DR EMBL; DS496110; EDP08368.1; -; Genomic_DNA.
DR RefSeq; XP_001696391.1; XM_001696339.1.
DR UniGene; Cre.14805; -.
DR STRING; 3055.EDP08368; -.
DR PaxDb; Q94EY1; -.
DR EnsemblPlants; EDP08368; EDP08368; CHLREDRAFT_24002.
DR GeneID; 5722152; -.
DR Gramene; EDP08368; EDP08368; CHLREDRAFT_24002.
DR KEGG; cre:CHLREDRAFT_24002; -.
DR eggNOG; ENOG410JNQU; Eukaryota.
DR eggNOG; ENOG4111CT9; LUCA.
DR InParanoid; Q94EY1; -.
DR Proteomes; UP000006906; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IDA:BHF-UCL.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0036157; C:outer dynein arm; IDA:BHF-UCL.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR InterPro; IPR031733; Dynein_attach_N.
DR InterPro; IPR025986; RPAP3-like_C.
DR Pfam; PF15867; Dynein_attach_N; 1.
DR Pfam; PF13877; RPAP3_C; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cilium biogenesis/degradation;
KW Complete proteome; Cytoplasm; Flagellum; Reference proteome.
FT CHAIN 1 267 Coiled-coil domain-containing protein 103
FT homolog.
FT /FTId=PRO_0000419464.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 100 205 ipfam:RPAP3_C [T]
FT MYHIT 10 73 ipfam:Dynein_attach_N [T]
SQ SEQUENCE 267 AA; 28727 MW; 2845DFF231724F45 CRC64;
MSSTPDHRPS KVSKELANAA CDDFKRKAID EAKKRAVAQR VDYDTFKNMV LTAHLKPITA
PKQLNNDRPL PCWSFGVDGK MLKEQISQSQ LPPTTPTEVP TTSGDFTRDW RRNCPTPDDK
YRYLKLCGPE GLQAVFRVEI SAEVLREMLA VLEACWLGHG GVAEEAEGGA GAALLEAAFV
VQVLEAVSTA GRFSLTVKLL GSSAKPTLER LFSGLQSAVL ASQAAHQGKQ EQPAAAEAPH
EEGGSTVDPC SPTRVAALQA MYGLPPS
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