Entry sw:POLG_WMV2A

ID   POLG_WMV2A              Reviewed;         302 AA.
AC   P20235;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   07-SEP-2016, entry version 64.
DE   RecName: Full=Genome polyprotein;
DE   Contains:
DE     RecName: Full=Nuclear inclusion protein B;
DE              Short=NI-B;
DE              Short=NIB;
DE     AltName: Full=RNA-directed RNA polymerase;
DE              EC=2.7.7.48;
DE   Contains:
DE     RecName: Full=Capsid protein;
DE              Short=CP;
DE     AltName: Full=Coat protein;
DE   Flags: Fragment;
OS   Watermelon mosaic virus II (isolate Australia).
OC   Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
OC   Potyviridae; Potyvirus.
OX   NCBI_TaxID=148358;
OH   NCBI_TaxID=3654; Citrullus lanatus (Watermelon) (Citrullus vulgaris).
OH   NCBI_TaxID=3656; Cucumis melo (Muskmelon).
OH   NCBI_TaxID=3659; Cucumis sativus (Cucumber).
OH   NCBI_TaxID=3663; Cucurbita pepo (Vegetable marrow) (Summer squash).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2794980; DOI=10.1099/0022-1317-70-10-2775;
RA   Frenkel M.J., Ward C.W., Shukla D.D.;
RT   "The use of 3' non-coding nucleotide sequences in the taxonomy of
RT   potyviruses: application to watermelon mosaic virus 2 and soybean
RT   mosaic virus-N.";
RL   J. Gen. Virol. 70:2775-2783(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 22-302.
RX   PubMed=2719555; DOI=10.1007/BF01311116;
RA   Yu M.H., Frenkel M.J., McKern N.M., Shukla D.D., Strike P.M.,
RA   Ward C.W.;
RT   "Coat protein of potyviruses. 6. Amino acid sequences suggest
RT   watermelon mosaic virus 2 and soybean mosaic virus-N are strains of
RT   the same potyvirus.";
RL   Arch. Virol. 105:55-64(1989).
RN   [3]
RP   REVIEW.
RX   PubMed=11226583; DOI=10.1016/S0168-1702(01)00220-9;
RA   Urcuqui-Inchima S., Haenni A.L., Bernardi F.;
RT   "Potyvirus proteins: a wealth of functions.";
RL   Virus Res. 74:157-175(2001).
CC   -!- FUNCTION: Capsid protein: involved in aphid transmission, cell-to-
CC       cell and systemis movement, encapsidation of the viral RNA and in
CC       the regulation of viral RNA amplification.
CC   -!- FUNCTION: Nuclear inclusion protein B: an RNA-dependent RNA
CC       polymerase that plays an essential role in the virus replication.
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1).
CC   -!- SUBCELLULAR LOCATION: Capsid protein: Virion {ECO:0000305}.
CC   -!- PTM: Genome polyprotein of potyviruses undergoes post-
CC       translational proteolytic processing by the main proteinase NIa-
CC       pro resulting in the production of at least ten individual
CC       proteins. The P1 proteinase and the HC-pro cleave only their
CC       respective C-termini autocatalytically. 6K1 is essential for
CC       proper proteolytic separation of P3 from CI (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the potyviridae genome polyprotein family.
CC       {ECO:0000305}.
DR   EMBL; D00535; BAA00423.1; -; Genomic_RNA.
DR   PIR; PS0084; PS0084.
DR   ProteinModelPortal; P20235; -.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR001592; Poty_coat.
DR   Pfam; PF00767; Poty_coat; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Nucleotidyltransferase; RNA-directed RNA polymerase;
KW   Transferase; Virion.
FT   CHAIN        <1     21       Nuclear inclusion protein B.
FT                                {ECO:0000250}.
FT                                /FTId=PRO_0000040493.
FT   CHAIN         1    302       Genome polyprotein.
FT                                /FTId=PRO_0000420032.
FT   CHAIN        22    302       Capsid protein. {ECO:0000250}.
FT                                /FTId=PRO_0000040494.
FT   SITE         21     22       Cleavage; by NIa-pro. {ECO:0000250}.
FT   NON_TER       1      1
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        67    297       ipfam:Poty_coat [T]
SQ   SEQUENCE   302 AA;  33860 MW;  D3AF006C844EB234 CRC64;
     KYLEVLDFNH IDGCCESVSL QSGKEAVENL DTGKDSKKDT SGKGDKPQNS QTGQGSKEQT
     KIGTVSKDVN VGSKGKEVPR LQKITKKMNL PTVGGKIILS LDHLLEYKPN QVDLFNTRAT
     KTEFESWYSA VKIEYDLNDE QMGVIMNGFM VWCIDNGTSP DVNGVWVMMD GEEQVEYPLK
     PIVENAKPTL RQIMHHFSDA AEAYIEMRNS ESPYMPRYGL LRNLRDRELA RYAFDFYEVT
     SKTPNRAREA IAQMKAAALA GINSRLFGLD GNISTNSENT ERHTARDVNQ NMHTLLGMGP
     PQ
//