ID POF11_SCHPO Reviewed; 506 AA.
AC Q09855; Q9P7V1;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 18-JAN-2017, entry version 131.
DE RecName: Full=F-box/WD repeat-containing protein pof11;
DE AltName: Full=Meiotically up-regulated gene 156 protein;
GN Name=pof11; Synonyms=mug156; ORFNames=SPAC29E6.01, SPAC30.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales;
OC Schizosaccharomycetaceae; Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Harrison C.L., Toda T.;
RT "Systematic genome-wide analysis of F-box protein-encoding genes in
RT fission yeast.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP INTERACTION WITH SKP1.
RX PubMed=15147268; DOI=10.1111/j.1356-9597.2004.00730.x;
RA Lehmann A., Katayama S., Harrison C., Dhut S., Kitamura K.,
RA McDonald N., Toda T.;
RT "Molecular interactions of fission yeast Skp1 and its role in the DNA
RT damage checkpoint.";
RL Genes Cells 9:367-382(2004).
RN [4]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L.,
RA San-Segundo P., Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes
RT required for critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the
RT fission yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBUNIT: Interacts with skp1. {ECO:0000269|PubMed:15147268}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Contains 1 F-box domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00080}.
CC -!- SIMILARITY: Contains 7 WD repeats. {ECO:0000255|PROSITE-
CC ProRule:PRU00221}.
DR EMBL; AB061694; BAB55543.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB66464.1; -; Genomic_DNA.
DR EMBL; Z66525; CAA91423.1; -; Genomic_DNA.
DR PIR; T38502; S62507.
DR PIR; T50211; T50211.
DR RefSeq; NP_594559.1; NM_001019988.2.
DR ProteinModelPortal; Q09855; -.
DR BioGrid; 278202; 11.
DR IntAct; Q09855; 1.
DR MINT; MINT-4695754; -.
DR PRIDE; Q09855; -.
DR EnsemblFungi; SPAC29E6.01.1; SPAC29E6.01.1:pep; SPAC29E6.01.
DR GeneID; 2541707; -.
DR KEGG; spo:SPAC29E6.01; -.
DR EuPathDB; FungiDB:SPAC29E6.01; -.
DR PomBase; SPAC29E6.01; pof11.
DR InParanoid; Q09855; -.
DR KO; K03362; -.
DR OMA; YLTTHEL; -.
DR OrthoDB; EOG092C10HM; -.
DR PhylomeDB; Q09855; -.
DR Reactome; R-SPO-174113; SCF-beta-TrCP mediated degradation of Emi1.
DR Reactome; R-SPO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q09855; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; IDA:PomBase.
DR GO; GO:0000151; C:ubiquitin ligase complex; ISM:PomBase.
DR GO; GO:0030674; F:protein binding, bridging; ISM:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; ISM:PomBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR017986; WD40_repeat_dom.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 2.
DR SUPFAM; SSF81383; SSF81383; 2.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Cytoplasm; Meiosis; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1 506 F-box/WD repeat-containing protein pof11.
FT /FTId=PRO_0000051138.
FT DOMAIN 70 116 F-box. {ECO:0000255|PROSITE-
FT ProRule:PRU00080}.
FT REPEAT 219 256 WD 1.
FT REPEAT 259 298 WD 2.
FT REPEAT 301 338 WD 3.
FT REPEAT 345 386 WD 4.
FT REPEAT 388 426 WD 5.
FT REPEAT 427 464 WD 6.
FT REPEAT 468 505 WD 7.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 70 116 iprf:FBOX [T]
FT MYHIT 419 455 ipfam:WD40 [T]
FT MYHIT 378 415 ismart:WD40 [T]
FT MYHIT 343 384 iprf:WD_REPEATS_2 [T]
FT MYHIT 254 289 ipfam:WD40 [T]
FT MYHIT 76 116 ismart:FBOX [T]
FT MYHIT 250 289 ismart:WD40 [T]
FT MYHIT 217 506 iprf:WD_REPEATS_REGION [T]
FT MYHIT 418 455 ismart:WD40 [T]
FT MYHIT 362 376 ipat:WD_REPEATS_1 [T]
FT MYHIT 217 256 iprf:WD_REPEATS_2 [T]
FT MYHIT 77 118 ipfam:F-box-like [T]
FT MYHIT 338 375 ipfam:WD40 [T]
FT MYHIT 257 298 iprf:WD_REPEATS_2 [T]
FT MYHIT 379 414 ipfam:WD40 [T]
FT MYHIT 214 247 ismart:WD40 [T]
FT MYHIT 28 62 ismart:WD40 [T]
FT MYHIT 234 248 ipat:WD_REPEATS_1 [T]
FT MYHIT 425 464 iprf:WD_REPEATS_2 [T]
FT MYHIT 385 424 iprf:WD_REPEATS_2 [T]
FT MYHIT 336 375 ismart:WD40 [T]
FT MYHIT 218 247 ipfam:WD40 [T]
FT MYHIT 442 456 ipat:WD_REPEATS_1 [T]
FT MYHIT 292 329 ismart:WD40 [T]
FT MYHIT 458 496 ismart:WD40 [T]
FT MYHIT 294 328 ipfam:WD40 [T]
FT MYHIT 299 338 iprf:WD_REPEATS_2 [T]
SQ SEQUENCE 506 AA; 58257 MW; CEF34D4EFFBC2E10 CRC64;
MNQDDNGKNV VSKVSDLTSC SDFSTSSPVP CLNPLSHENN RIDLIRDLLA SLSKEGVVAV
YNHVRSLLFT DFTEVFPEEV SLRVFSYLDQ LDLCKCKLMS KRWKRLLEDP GIWKALYMQK
GWFVNENVLN EFEAWRRTHK FPQPRFENFL KQQNIIGPYG TMFLPQQFIF DSNGRPLLNW
SYLYKEHAHL DSNWRHGRFL VSTFNNPSIR FPADQDFRAT LDSVYCVQYD DEIMVSGSKD
RTVSVWDVNS RFILYKLYGH SGSVLCLDFC RRRNLLVSGS SDSTIIIWDW QNRRPLKVYF
GHTDNVLGVV VSENYIISSS RDHTARVWRL DATSPAEACM HVLRGHLASV NSVQYSSKTG
LIVTASSDRT LRTWDITTGH CIRIIHAHQR GIACAQYNGK FIVSGSSDLT IRIFEASSGK
LLRMLQGHED LIRTVRFNDE KIVSGGYDGT VRIWNFNTGE QHCVLHNSRN SRVFGLQFDH
RRIIACTHSS EILVWNFDDG LDCTFF
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