ID PITA_ECOL6 Reviewed; 499 AA.
AC P0AFJ8; P37308;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 02-NOV-2016, entry version 66.
DE RecName: Full=Low-affinity inorganic phosphate transporter 1;
GN Name=pitA; OrderedLocusNames=c4291;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P.,
RA Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D.,
RA Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T.,
RA Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence
RT of uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Low-affinity inorganic phosphate transport. Can also
CC transport arsenate (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT)
CC (TC 2.A.20) family. Pit subfamily. {ECO:0000305}.
DR EMBL; AE014075; AAN82727.1; -; Genomic_DNA.
DR RefSeq; WP_000902780.1; NC_004431.1.
DR ProteinModelPortal; P0AFJ8; -.
DR STRING; 199310.c4291; -.
DR EnsemblBacteria; AAN82727; AAN82727; c4291.
DR KEGG; ecc:c4291; -.
DR PATRIC; 18286311; VBIEscCol75197_4031.
DR eggNOG; ENOG4105CJ3; Bacteria.
DR eggNOG; COG0306; LUCA.
DR HOGENOM; HOG000231893; -.
DR KO; K16322; -.
DR OMA; YDITRTR; -.
DR BioCyc; ECOL199310:C4291-MONOMER; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PTHR11101; 1.
DR Pfam; PF01384; PHO4; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Complete proteome; Membrane;
KW Phosphate transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 499 Low-affinity inorganic phosphate
FT transporter 1.
FT /FTId=PRO_0000080784.
FT TOPO_DOM 1 4 Periplasmic. {ECO:0000255}.
FT TRANSMEM 5 25 Helical. {ECO:0000255}.
FT TOPO_DOM 26 51 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 52 72 Helical. {ECO:0000255}.
FT TOPO_DOM 73 93 Periplasmic. {ECO:0000255}.
FT TRANSMEM 94 114 Helical. {ECO:0000255}.
FT TOPO_DOM 115 123 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 124 144 Helical. {ECO:0000255}.
FT TOPO_DOM 145 154 Periplasmic. {ECO:0000255}.
FT TRANSMEM 155 175 Helical. {ECO:0000255}.
FT TOPO_DOM 176 206 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 207 227 Helical. {ECO:0000255}.
FT TOPO_DOM 228 232 Periplasmic. {ECO:0000255}.
FT TRANSMEM 233 253 Helical. {ECO:0000255}.
FT TOPO_DOM 254 381 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 382 402 Helical. {ECO:0000255}.
FT TOPO_DOM 403 429 Periplasmic. {ECO:0000255}.
FT TRANSMEM 430 450 Helical. {ECO:0000255}.
FT TOPO_DOM 451 472 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 473 493 Helical. {ECO:0000255}.
FT TOPO_DOM 494 499 Periplasmic. {ECO:0000255}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 30 488 ipfam:PHO4 [T]
SQ SEQUENCE 499 AA; 53389 MW; 93D551131C524084 CRC64;
MLHLFAGLDL HTGLLLLLAL AFVLFYEAIN GFHDTANAVA TVIYTRAMRS QLAVVMAAVF
NFLGVLLGGL SVAYAIVHML PTDLLLNMGS SHGLAMVFSM LLAAIIWNLG TWYFGLPASS
SHTLIGAIIG IGLTNALMTG TSVVDALNIP KVLSIFGSLI VSPIVGLVFA GGLIFLLRRY
WSGTKKRARI HLTPAEREKK DGKKKPPFWT RIALILSAIG VAFSHGANDG QKGIGLVMLV
LIGVAPAGFV VNMNATGYEI TRTRDAINNV EAYFEQHPAL LKQATGADQL VPAPEAGATQ
PAEFHCHPSN TINALNRLKG MLTTDVESYD KLSLDQRSQM RRIMLCVSDT IDKVVKMPGV
SADDQRLLKK LKSDMLSTIE YAPVWIIMAV ALALGIGTMI GWRRVATTIG EKIGKKGMTY
AQGMSAQMTA AVSIGLASYT GMPVSTTHVL SSSVAGTMVV DGGGLQRKTV TSILMAWVFT
LPAAVLLSGG LYWLSLQFL
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