Entry sw:PEF1_RAT

ID   PEF1_RAT                Reviewed;         283 AA.
AC   Q641Z8;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   30-NOV-2016, entry version 88.
DE   RecName: Full=Peflin;
DE   AltName: Full=PEF protein with a long N-terminal hydrophobic domain;
DE   AltName: Full=Penta-EF hand domain-containing protein 1;
GN   Name=Pef1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Heterodimer; heterodimerizes with PDCD6. Dissociates from
CC       PDCD6 in presence of Ca(2+) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane
CC       protein. Note=Membrane-associated in the presence of Ca(2+).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Contains 5 EF-hand domains. {ECO:0000255|PROSITE-
CC       ProRule:PRU00448}.
DR   EMBL; BC082028; AAH82028.1; -; mRNA.
DR   RefSeq; NP_001007652.1; NM_001007651.1.
DR   UniGene; Rn.96097; -.
DR   ProteinModelPortal; Q641Z8; -.
DR   STRING; 10116.ENSRNOP00000018742; -.
DR   PaxDb; Q641Z8; -.
DR   PRIDE; Q641Z8; -.
DR   Ensembl; ENSRNOT00000018742; ENSRNOP00000018742; ENSRNOG00000013972.
DR   GeneID; 297900; -.
DR   KEGG; rno:297900; -.
DR   CTD; 553115; -.
DR   RGD; 1359536; Pef1.
DR   eggNOG; KOG0037; Eukaryota.
DR   eggNOG; ENOG410YKQK; LUCA.
DR   GeneTree; ENSGT00620000087734; -.
DR   HOGENOM; HOG000231983; -.
DR   HOVERGEN; HBG004492; -.
DR   InParanoid; Q641Z8; -.
DR   OMA; PSMQLDR; -.
DR   OrthoDB; EOG091G0ISY; -.
DR   PhylomeDB; Q641Z8; -.
DR   TreeFam; TF314682; -.
DR   PRO; PR:Q641Z8; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000013972; -.
DR   Genevisible; Q641Z8; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0044822; F:poly(A) RNA binding; IEA:Ensembl.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   CDD; cd00051; EFh; 1.
DR   Gene3D; 1.10.238.10; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13202; EF-hand_5; 1.
DR   Pfam; PF13405; EF-hand_6; 1.
DR   SMART; SM00054; EFh; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Cytoplasm; Membrane; Metal-binding;
KW   Reference proteome; Repeat.
FT   CHAIN         1    283       Peflin.
FT                                /FTId=PRO_0000247047.
FT   REPEAT       21     29       1.
FT   REPEAT       31     39       2.
FT   REPEAT       41     48       3.
FT   REPEAT       49     58       4.
FT   REPEAT       59     67       5.
FT   REPEAT       75     83       6.
FT   REPEAT       84     91       7.
FT   REPEAT       92     99       8.
FT   REPEAT      100    108       9.
FT   DOMAIN      113    148       EF-hand 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   DOMAIN      149    179       EF-hand 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   DOMAIN      180    215       EF-hand 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   DOMAIN      216    252       EF-hand 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   DOMAIN      253    282       EF-hand 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   CA_BIND     126    137       1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   CA_BIND     193    204       2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00448}.
FT   REGION       21    108       9 X 9 AA approximate tandem repeat of
FT                                [AP]-P-G-G-P-Y-G-G-P-P.
FT   REGION      203    283       Required for interaction with PDCD6.
FT                                {ECO:0000250}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       180    215       iprf:EF_HAND_2 [T]
FT   MYHIT       185    211       ipfam:EF-hand_6 [T]
FT   MYHIT       154    182       ismart:EFh [T]
FT   MYHIT       117    145       ismart:EFh [T]
FT   MYHIT       184    212       ismart:EFh [T]
FT   MYHIT       113    148       iprf:EF_HAND_2 [T]
FT   MYHIT       193    205       ipat:EF_HAND_1 [T]
FT   MYHIT       126    138       ipat:EF_HAND_1 [T]
FT   MYHIT       121    142       ipfam:EF-hand_5 [T]
SQ   SEQUENCE   283 AA;  30012 MW;  2454D005C02C595D CRC64;
     MASYPDGQSY PGAAGQVPGP HPGGYYPGPP HGGGQYGSGF PPGGYGAPAP GGPYGYPSAG
     GTPSGTPGGP YGGGPPGGPY GGGPPGGPYG QAHPSPYGTQ PPGPYGQGGV PPNVDPEAYS
     WFQSVDADHS GYISLKELKQ ALVNSNWSSF NDETCLMMIN MFDKTKTGRI DVVGFSALWK
     FLQQWKNLFQ QYDRDHSGSI SSTELQQALS QMGYNLSPQF TQLLVSRYCT RSAIPAMQLD
     CFIKVCTQLQ VLTEAFREKD TAVQGNIRLS FEDFVTMTAS RML
//