ID OSM1_DROME Reviewed; 1754 AA.
AC Q9W040;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 3.
DT 18-JAN-2017, entry version 132.
DE RecName: Full=Intraflagellar transport protein 172 homolog {ECO:0000250|UniProtKB:Q5DM57};
DE AltName: Full=Osmotic avoidance abnormal protein 1 homolog;
DE AltName: Full=Outer segment 2;
GN Name=Oseg2 {ECO:0000312|FlyBase:FBgn0035317}; Synonyms=osm-1;
GN ORFNames=CG13809 {ECO:0000312|FlyBase:FBgn0035317};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Required for the maintenance and formation of cilia.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IFT172 family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 11 TPR repeats. {ECO:0000305}.
CC -!- SIMILARITY: Contains 7 WD repeats. {ECO:0000305}.
DR EMBL; AE014296; AAF47619.3; -; Genomic_DNA.
DR RefSeq; NP_647700.2; NM_139443.2.
DR UniGene; Dm.15839; -.
DR ProteinModelPortal; Q9W040; -.
DR BioGrid; 63798; 2.
DR IntAct; Q9W040; 7.
DR STRING; 7227.FBpp0304907; -.
DR PaxDb; Q9W040; -.
DR PRIDE; Q9W040; -.
DR EnsemblMetazoa; FBtr0332661; FBpp0304907; FBgn0035317.
DR GeneID; 38282; -.
DR KEGG; dme:Dmel_CG13809; -.
DR CTD; 38282; -.
DR FlyBase; FBgn0035317; Oseg2.
DR eggNOG; KOG3616; Eukaryota.
DR eggNOG; ENOG410XR2C; LUCA.
DR GeneTree; ENSGT00440000033648; -.
DR InParanoid; Q9W040; -.
DR KO; K19676; -.
DR OMA; EDIHLKN; -.
DR OrthoDB; EOG091G02TF; -.
DR Reactome; R-DME-5610787; Hedgehog 'off' state.
DR GenomeRNAi; 38282; -.
DR PRO; PR:Q9W040; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035317; -.
DR Genevisible; Q9W040; DM.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0030990; C:intraciliary transport particle; ISS:FlyBase.
DR GO; GO:0030992; C:intraciliary transport particle B; IBA:GO_Central.
DR GO; GO:0005871; C:kinesin complex; ISS:FlyBase.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0042073; P:intraciliary transport; IMP:FlyBase.
DR GO; GO:0007018; P:microtubule-based movement; ISS:FlyBase.
DR GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR017986; WD40_repeat_dom.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 3: Inferred from homology;
KW Cell projection; Cilium; Complete proteome; Developmental protein;
KW Reference proteome; Repeat; TPR repeat; WD repeat.
FT CHAIN 1 1754 Intraflagellar transport protein 172
FT homolog.
FT /FTId=PRO_0000328946.
FT REPEAT 14 53 WD 1.
FT REPEAT 64 103 WD 2.
FT REPEAT 110 149 WD 3.
FT REPEAT 151 190 WD 4.
FT REPEAT 194 232 WD 5.
FT REPEAT 283 322 WD 6.
FT REPEAT 519 557 WD 7.
FT REPEAT 623 656 TPR 1.
FT REPEAT 690 723 TPR 2.
FT REPEAT 748 781 TPR 3.
FT REPEAT 807 840 TPR 4.
FT REPEAT 852 885 TPR 5.
FT REPEAT 1041 1074 TPR 6.
FT REPEAT 1140 1166 TPR 7.
FT REPEAT 1167 1199 TPR 8.
FT REPEAT 1211 1250 TPR 9.
FT REPEAT 1282 1315 TPR 10.
FT REPEAT 1698 1733 TPR 11.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 224 266 ismart:WD40 [T]
FT MYHIT 141 180 ismart:WD40 [T]
FT MYHIT 185 222 ismart:WD40 [T]
FT MYHIT 102 139 ismart:WD40 [T]
FT MYHIT 278 313 ismart:WD40 [T]
FT MYHIT 2 44 ismart:WD40 [T]
FT MYHIT 54 94 ismart:WD40 [T]
SQ SEQUENCE 1754 AA; 195708 MW; 673CE3C889A0C50B CRC64;
MQLKYLRTLL EGQEQIQRIA GLAWSPNQQR LAIATADRHI LLYDDAGERR DKFSTKPANP
ANGKNSYVIR GLAFSPDSTK LAVGQSDSIV YVYKLGESWN DKKVICNKFP QASAVTALIW
LTSGSIIAGL EDGKVRALHS KSNKSQSLYG GDSICISLAA NTKGTGFLSG HNDGTIIRYF
MTDEATEPLG RVVQHPVPPF ALAWPQGGFC AGGCDQRIVF YDSMGRQLRT FDHSRTEGER
EFTVAACSPN GQAVAFGSFD RIRIFAWSPR QGAWSESATK EVACLYTLSS LLWRRDGARL
ALGSVSGAVL LFESVLRRTV WQDKFELIFV APSQLLVRSL TEPSQALTIE SQLGLEIDDV
RIMGRDNYLV ARTEESLILC DLTRNLSSEV PWTASGHHER FYFENPTVCL IFNVGELSLV
EYGENSILGS VRTEFVNPHV ISVRLNERGN AKENKKLAFL LDAKTICVVD LISRMTSGQI
SHETKIDWLE LSETAHKLLF RDKKLRLILV DNYTGKKQTL LSNISFVQWV PQSDVVVAQS
NSNLAIWYNI DLPEHVTMQS VRGEAIEVLR ENGRTVVRSQ DGPSEHNYQL DEGLVEFGTA
VNDSDFGRAV HFLESLGDKP AAKAMWHNLA LIALEDGNLR VAQRCYAALG NVSKAYYLAG
MIQQADEFEE SSGSPGILCP EVRAKLALLG SDLRTAERIY LEQGDIESAL KMYQQLGMWD
EAVALAERRG YNRIAELKQQ HMDYLLSSEQ QEKAGQVLEE QGDLQQAMSL YMKANKPARA
ARLALKTPHI LQDEQVMLQV TEGLVRSELY ELAGDIAHRL SRPEAALALY RKGGAYARAL
EIGRVVAPQE VTALEEEWGD WLVSRKQLDA SINHYIEAGA TQKALEAAVG AKQWRKAVQI
AKVLDEPELI QRYAVDLAKH LAFAGDLDGA EDMLVRANLH KDAIELLNRH GKWERAYLIG
EKHLKAEQVR ELFVQLAGTL EEQGKFRDAE KVLIAVNEPD LAIAMYKRRE LYDSMIRLVE
RYHKDLLDST HLHLARQLES RGKLKNAEMH FVASGDWKSA VHMYCSSGRW EDGYRVAKLK
GTEGASQQVA YMWAKSMPTE GAVRLLSKLG LLDTAVGFAC DSGQFEFAME LCKFAGKPTD
EVHLKIAMSL EDEGKFEAAE AEFLKANKPR EAILMYQHAG DWQAALNVAE NHLPDAVGEV
LIGQASAALE TSNYKDYEAL LLRAHRPDLI IEHYKQESLY EDALRIAEEH YPSALNDLRR
LQAQLQRGQA QAQAGEDAAS ISRSYLQKAA EFAKKEQFRK AAECLMQIDS SNAEDASTLE
RALLRAAEIC NQFLEGQDAQ ELAQSLGPRL LAIKQIGPAA QLYLAADMPK QAVDVFIKTE
QWSKARRLAK EIDPDLQLLA YVEQQQKASL KHEGNIEQLA DIDIVSALDL LAEHGEWQRC
LEKAKGLNPA LLQKYVAVYA AQLIREGNCT TALGLYLSYG APPIEAHFNI YTRIALDCLA
LREEQTERGT TWRQLRDFLF RLLQSLKATP AQSQTKFAAS MEQFLLIAHY YATRAACKEV
QALQPVALRL SLALLRHTDL LPVDKGFYEA GMDLRQAGRE AEAFVMLNHY LDVCEAIEEG
SGQLVDHSDL ASTDFPSSVP LPEDIHLKND PSLHEEVREW VLAVSMDQQV DQQLPTDDRG
LYESSLGPND LPCMLSGFPV RGRQPVTFQG SSNQVNRDVW SKFSVALKMS PGSGIADIIS
FTEKWQGAAN YVMH
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