| Description | RecName: Full=Outer membrane protein A; AltName: Full=190 kDa antigen; AltName: Full=Cell surface antigen; AltName: Full=rOmp A; Short=rOmpA; Contains: RecName: Full=120 kDa surface-exposed protein; AltName: Full=120 kDa outer membrane protein OmpA; Contains: RecName: Full=32 kDa beta peptide; Flags: Precursor; |
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| MyHits synonyms | OMPA_RICCN
, Q52657
, P95591
, P95592
, P95593
, P95594
, Q52667
, Q52668
, Q52669
, Q52670
, Q52674
, 327FC42D7CB24668
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Legends: 1, VARIANT N -> NN (in strain: Indian tick typhus); 2, VARIANT R -> H (in strain: Indian tick typhus); 3, VARIANT D -> A (in strain: Indian tick typhus, M1 and Moroccan); 4, VARIANT N -> H (in strain: Moroccan); 5, VARIANT M -> I (in strain: Indian tick typhus); 6, CONFLICT Q -> K (in Ref. 1; AAA17405). {ECO:0000305}; 7, CONFLICT I -> V (in Ref. 1; AAA17405). {ECO:0000305}; 8, CONFLICT V -> I (in Ref. 1; AAA17405). {ECO:0000305}; 9, CONFLICT T -> N (in Ref. 1; AAA17405). {ECO:0000305}; 10, CONFLICT G -> D (in Ref. 1; AAA17405). {ECO:0000305}; 11, CONFLICT N -> D (in Ref. 1; AAA17405). {ECO:0000305}; 12, CONFLICT D -> Y (in Ref. 1; AAA17405). {ECO:0000305}; 13, CONFLICT P -> N (in Ref. 1; AAA17405). {ECO:0000305}; 14, CONFLICT N -> K (in Ref. 1; AAA17405). {ECO:0000305}; 15, CONFLICT L -> S (in Ref. 1; AAA17405). {ECO:0000305}; 16, CONFLICT Y -> S (in Ref. 1; AAA17405). {ECO:0000305}; 17, CONFLICT K -> Q (in Ref. 1; AAA17405). {ECO:0000305}; 18, CONFLICT N -> Y (in Ref. 4; AAC35189). {ECO:0000305}; 19, CONFLICT H -> N (in Ref. 1; AAA17405). {ECO:0000305}; 20, CONFLICT E -> G (in Ref. 1; AAA17405). {ECO:0000305}; 21, CONFLICT A -> V (in Ref. 1; AAA17405). {ECO:0000305}; 22, CONFLICT T -> P (in Ref. 1; AAA17405). {ECO:0000305}; 23, CONFLICT E -> A (in Ref. 1; AAA17405). {ECO:0000305}; 24, CONFLICT G -> R (in Ref. 1; AAA17405). {ECO:0000305}; 25, SIGNAL {ECO:0000255}; 26, Autotransporter. {ECO:0000255|PROSITE- ProRule:PRU00556}; 27, COMPBIAS Thr-rich; 28, VARIANT Missing (in strain: M1); 29, VARIANT Missing (in strain: Moroccan); 30, VARIANT VT -> II (in strain: Indian tick typhus); 31, CONFLICT IS -> VN (in Ref. 1; AAA17405). {ECO:0000305}; 32, CONFLICT KATLGGAIIKATTTK -> LLQVQGGVVKANTIN (in Ref. 1; AAA17405). {ECO:0000305}; 33, CONFLICT VN -> IS (in Ref. 1; AAA17405). {ECO:0000305}; 34, CONFLICT LLRVQGGVVKSNTIN -> KATLGGAIIKATTTK (in Ref. 1; AAA17405). {ECO:0000305}; 35, CONFLICT MS -> LP (in Ref. 1; AAA17405). {ECO:0000305}; 36, CONFLICT MTAPLP -> ITPPLS (in Ref. 1; AAA17405). {ECO:0000305}; 37, iprf:AUTOTRANSPORTER [T]; 38, ipfam:Autotransporter [T]; 39, ismart:Autotransporter [T].
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ID OMPA_RICCN Reviewed; 2021 AA.
AC Q52657; P95591; P95592; P95593; P95594; Q52667; Q52668; Q52669;
AC Q52670; Q52674;
DT 11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2001, sequence version 2.
DT 07-SEP-2016, entry version 101.
DE RecName: Full=Outer membrane protein A;
DE AltName: Full=190 kDa antigen;
DE AltName: Full=Cell surface antigen;
DE AltName: Full=rOmp A;
DE Short=rOmpA;
DE Contains:
DE RecName: Full=120 kDa surface-exposed protein;
DE AltName: Full=120 kDa outer membrane protein OmpA;
DE Contains:
DE RecName: Full=32 kDa beta peptide;
DE Flags: Precursor;
GN Name=ompA; OrderedLocusNames=RC1273;
OS Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=272944;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC VR-613 / Malish 7;
RX PubMed=8125327; DOI=10.1016/0378-1119(94)90740-4;
RA Crocquet-Valdes P.A., Weiss K., Walker D.H.;
RT "Sequence analysis of the 190-kDa antigen-encoding gene of Rickettsia
RT conorii (Malish 7 strain).";
RL Gene 140:115-119(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-613 / Malish 7;
RX PubMed=11557893; DOI=10.1126/science.1061471;
RA Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M.,
RA Raoult D.;
RT "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL Science 293:2093-2098(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-204.
RC STRAIN=ATCC VR-613 / Malish 7, Indian tick typhus, M1, and Moroccan;
RX PubMed=8862558;
RA Roux V., Fournier P.E., Raoult D.;
RT "Differentiation of spotted fever group rickettsiae by sequencing and
RT analysis of restriction fragment length polymorphism of PCR-amplified
RT DNA of the gene encoding the protein rOmpA.";
RL J. Clin. Microbiol. 34:2058-2065(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 953-2012.
RC STRAIN=ATCC VR-613 / Malish 7, Indian tick typhus, M1, and Moroccan;
RA Raoult D., Fournier P.E., Roux V.;
RT "Phylogenetic analysis of spotted fever group rickettsiae by study of
RT the outer surface protein rOmpA.";
RL Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Elicits protective immunity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Outer membrane protein A: Periplasm
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: 120 kDa surface-exposed protein: Secreted
CC {ECO:0000250}. Cell surface {ECO:0000250}. Note=Surface exposed.
CC This bacterium is covered by a S-layer with hexagonal symmetry.
CC -!- SUBCELLULAR LOCATION: 32 kDa beta peptide: Cell outer membrane
CC {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=The
CC cleaved C-terminal fragment (autotransporter domain) is localized
CC in the outer membrane.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the rickettsiae OmpA/OmpB family.
CC {ECO:0000305}.
CC -!- SIMILARITY: Contains 1 autotransporter (TC 1.B.12) domain.
CC {ECO:0000255|PROSITE-ProRule:PRU00556}.
DR EMBL; U01028; AAA17405.1; -; Unassigned_DNA.
DR EMBL; AE006914; AAL03811.1; -; Genomic_DNA.
DR EMBL; U43794; AAB49549.1; -; Genomic_DNA.
DR EMBL; U43798; AAB49550.1; -; Genomic_DNA.
DR EMBL; U43806; AAB49551.1; -; Genomic_DNA.
DR EMBL; U45244; AAB49566.1; -; Genomic_DNA.
DR EMBL; U46918; AAA86663.1; -; Genomic_DNA.
DR EMBL; U83440; AAC35176.1; -; Genomic_DNA.
DR EMBL; U83443; AAC35179.1; -; Genomic_DNA.
DR EMBL; U83448; AAC35184.1; -; Genomic_DNA.
DR EMBL; U83453; AAC35189.1; -; Genomic_DNA.
DR PIR; A97859; A97859.
DR RefSeq; WP_010977835.1; NC_003103.1.
DR ProteinModelPortal; Q52657; -.
DR EnsemblBacteria; AAL03811; AAL03811; RC1273.
DR GeneID; 928425; -.
DR KEGG; rco:RC1273; -.
DR PATRIC; 17890068; VBIRicCon45613_1464.
DR OMA; NTNALAT; -.
DR OrthoDB; POG091H01XL; -.
DR Proteomes; UP000000816; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR Gene3D; 2.40.128.130; -; 1.
DR InterPro; IPR005546; Autotransporte_beta.
DR InterPro; IPR006315; OM_autotransptr_brl.
DR Pfam; PF03797; Autotransporter; 1.
DR SMART; SM00869; Autotransporter; 1.
DR SUPFAM; SSF103515; SSF103515; 1.
DR TIGRFAMs; TIGR01414; autotrans_barl; 1.
DR PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Complete proteome; Glycoprotein; Membrane;
KW Periplasm; Repeat; Secreted; Signal; Transmembrane;
KW Transmembrane beta strand.
FT SIGNAL 1 38 {ECO:0000255}.
FT CHAIN 39 2021 Outer membrane protein A.
FT /FTId=PRO_0000032646.
FT CHAIN 39 ? 120 kDa surface-exposed protein.
FT /FTId=PRO_0000387575.
FT CHAIN ? 2021 32 kDa beta peptide.
FT /FTId=PRO_0000387576.
FT DOMAIN 1734 2021 Autotransporter. {ECO:0000255|PROSITE-
FT ProRule:PRU00556}.
FT COMPBIAS 238 946 Thr-rich.
FT COMPBIAS 1424 1528 Thr-rich.
FT VARIANT 60 60 N -> NN (in strain: Indian tick typhus).
FT VARIANT 76 76 R -> H (in strain: Indian tick typhus).
FT VARIANT 86 137 Missing (in strain: M1).
FT VARIANT 126 133 Missing (in strain: Moroccan).
FT VARIANT 953 954 VT -> II (in strain: Indian tick typhus).
FT VARIANT 1245 1245 D -> A (in strain: Indian tick typhus, M1
FT and Moroccan).
FT VARIANT 1308 1308 N -> H (in strain: Moroccan).
FT VARIANT 1877 1877 M -> I (in strain: Indian tick typhus).
FT CONFLICT 10 10 Q -> K (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 92 92 I -> V (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 126 126 V -> I (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 137 137 T -> N (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 157 157 G -> D (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 368 369 IS -> VN (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 374 388 KATLGGAIIKATTTK -> LLQVQGGVVKANTIN (in
FT Ref. 1; AAA17405). {ECO:0000305}.
FT CONFLICT 640 640 N -> D (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 669 669 V -> I (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 793 793 N -> D (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 803 804 VN -> IS (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 809 823 LLRVQGGVVKSNTIN -> KATLGGAIIKATTTK (in
FT Ref. 1; AAA17405). {ECO:0000305}.
FT CONFLICT 898 898 D -> Y (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 908 908 P -> N (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 985 985 N -> K (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1009 1009 L -> S (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1013 1013 Y -> S (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1182 1182 K -> Q (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1314 1314 N -> Y (in Ref. 4; AAC35189).
FT {ECO:0000305}.
FT CONFLICT 1451 1451 H -> N (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1624 1624 G -> D (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1628 1628 E -> G (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1872 1872 A -> V (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1875 1875 T -> P (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1878 1879 MS -> LP (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1936 1936 E -> A (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1965 1970 MTAPLP -> ITPPLS (in Ref. 1; AAA17405).
FT {ECO:0000305}.
FT CONFLICT 1997 1997 G -> R (in Ref. 1; AAA17405).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1734 2021 iprf:AUTOTRANSPORTER [T]
FT MYHIT 1741 1992 ipfam:Autotransporter [T]
FT MYHIT 1738 2011 ismart:Autotransporter [T]
SQ SEQUENCE 2021 AA; 203330 MW; 327FC42D7CB24668 CRC64;
MANISPKLFQ KAIQQGLKAA LFTTSTAAIM LSSSGALGIA VSGVIATNNN AAFSDNVGNN
WNEITAAGVA NGTPARGPQN NWAFTYGGDY TITADVADHI ITAINVADTT PIGLNIAQNT
VVGSIVTGGN LLPVTITAGK SLTLNGNNAD AANHGFGAPA DNYTGLGNIA LGGANAALII
QSAAPAKITL AGNINGGGII TVKTDAAING TIGNTNALAT VNVGAGIATL EGAIIKATTT
KLTNAASVLT LTNVNAVLTG AIDNTTGVDN VGVLNLNGAL SQVTGNIGNT NALATISVGA
GKATLGGAVI KATTTKLTDN ASAVTFTNPV VVTGAIDNTG NANNGIVTFT GDSTVTGNIG
NTNALATISV GAGKATLGGA IIKATTTKLT DNASAVTFTN PVVVTGAIDN TGNANNGIVT
FTGDSTVTGN IGNTNALATI SVGAGKATLG GAIIKATTTK LTDNASAVTF TNPVVVTGAI
DNTGNANNGI VTFTGDSTVT GNIGNTNALA TISVGAGKAT LGGAIIKATT TKLTDNASAV
TFTNPVVVTG AIDNTGNANN GIVTFTGDST VTGNIGNTNA LATISVGAGK ATLGGAIIKA
TTTKLTDNAS AVTFTNPVVV TGAIDNTGNA NNGIVTFTGN STVTGNIGNT NALATVNVGA
GIATLEGAVI KATTTKLTNA ASVLTLTNVN AVLTGAIDNT TGVDNVGVLN LNGALSQVTG
NIGNTNALAT ISVGAGKATL GGAVIKATTT KLTDNASAVT FTNPVVVTGA IDNTGNANNG
IATFTGDSTV TGNIGNTNAL ATVNVGAGLL RVQGGVVKSN TINLTDNASA VTFTNPVVVT
GAIDNTGNAN NGIVTFTGDS TVTGNIGNTN ALATISVGAG KATLGGAIIK ATTTKLTDNA
SAVTFTNPVV VTGAIDNTGN ANNGIVTFTG DSTVTGNIGN TNALATVNVG AGVTLQAGGS
LDANNIDFGA RSTLEFNGPL DGGGNAIPYY FKGAIANGNN AILNVNTKLL TAYHLTIGTV
AEINIGAGNL FAIDASAGDV TILNAQDIHF RALDSALVLS NLTGVGVNNI LLAADLVAPG
VDEGTVVFDG GVNGLNIGSN VAGAARNIGD VGGNKFNTLL IYNAVTITDD VNLEGIQNVL
INNNADFTSS TAFNAGTIQI NDATYTIDAN NGNLNIPAGN IKFAHADAQL ILQNSSGNDR
TITLGANIDP DNDDEGIVIL NSVTAGKKLT IAGGKTFGGA HKLQDIVFKG EGDFGTAGTT
FNTTNIVLDI TGQLELGATT ANVVLFKDAV QLTQTGNIGG FLDFNAKNGT VTLNNNVNVA
GTVKNTGGTN NGTLIVLGAS NLNRVNGIAM LKVGAGNVTI AKGGNVKIGE IQGTGTNTLT
LPAHFKLTGS INKTGGQALK LNFMNGGSVS GVVGTAANSV GDITTAGATS FASSVNAKGT
ATLGGTTSFA HTFTNTGAVT LAKGSITSFA KNVTATSFVA NSATINFGNS LAFNSNITGS
GTTLTLGANQ VTYTGTGSFT DTLTLNTTFD GAAKSGGNIL IKSGSTLDLS GVSNLALVVT
ATNFDMNNIS PDTKYTVISA ETAGGLKPTP KENVKITINN DNRFVDFTFD ASTLTLFAED
IAAGVIDEDF APGGPLANIP NAANIKKSLE LMEDAPNGSD ARQAFNNFGL MTPLQEADAT
THLMQDVVKP SDTIAAVNNQ VVASNISSNI TALNARMDKV QAGNKGPVSS GDEDMDAKFG
AWISPFVGNA TQKMCNSISG YKSDTTGGTI GFDGFVSDDL VLGLAYTRAD TDIKLKNNKT
GDKNKVESNI YSLYGLYSVP YENLFVEAIA SYSDNKIRSK SRRVIATTLE TVGYQTANGK
YKSESYTGQL MAGYTYMMSE NINLTPLAGL RYSTIKDKSY KETGTTYQNL TVKGKNYNTF
DGLLGAKVSS NINVNEIVLT PELYAMVDYA FKNKVSAIDA RLQGMTAPLP TNSFKQSKTS
FDVGVGVTAK HKMMEYGINY DTNIGSKYFA QQGSVKVRVN F
//
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