Entry sw:OL139_MOUSE

ID   OL139_MOUSE             Reviewed;         315 AA.
AC   Q60891; Q8VGR1; Q9EPY8;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 2.
DT   02-NOV-2016, entry version 120.
DE   RecName: Full=Olfactory receptor 139;
DE   AltName: Full=Odorant receptor M5;
DE   AltName: Full=Olfactory receptor 1;
DE   AltName: Full=Olfactory receptor 255-2;
GN   Name=Olfr139; Synonyms=Mor255-2, Olfr1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11802173; DOI=10.1038/nn800;
RA   Zhang X., Firestein S.;
RT   "The olfactory receptor gene superfamily of the mouse.";
RL   Nat. Neurosci. 5:124-133(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA   Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA   Trask B.J.;
RT   "Different evolutionary processes shaped the mouse and human olfactory
RT   receptor gene families.";
RL   Hum. Mol. Genet. 11:535-546(2002).
RN   [3]
RP   ERRATUM.
RA   Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA   Trask B.J.;
RL   Hum. Mol. Genet. 11:1683-1683(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-242.
RC   STRAIN=129S6/SvEvTac;
RX   PubMed=11170746; DOI=10.1006/geno.2000.6431;
RA   Lapidot M., Pilpel Y., Gilad Y., Falcovitz A., Sharon D., Haaf T.,
RA   Lancet D.;
RT   "Mouse-human orthology relationships in an olfactory receptor gene
RT   cluster.";
RL   Genomics 71:296-306(2001).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 131-242.
RC   STRAIN=C57BL/6J;
RX   PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA   Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT   "The chromosomal distribution of mouse odorant receptor genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
DR   EMBL; AY073085; AAL60748.1; -; Genomic_DNA.
DR   EMBL; AY317501; AAP70924.1; -; Genomic_DNA.
DR   EMBL; AL611937; CAI24630.1; -; Genomic_DNA.
DR   EMBL; BC104101; AAI04102.1; -; mRNA.
DR   EMBL; BC104102; AAI04103.1; -; mRNA.
DR   EMBL; AF309126; AAG42796.1; -; Genomic_DNA.
DR   EMBL; U28780; AAC52403.1; -; Genomic_DNA.
DR   CCDS; CCDS25023.1; -.
DR   RefSeq; NP_667214.1; NM_147003.1.
DR   UniGene; Mm.377784; -.
DR   ProteinModelPortal; Q60891; -.
DR   STRING; 10090.ENSMUSP00000049558; -.
DR   iPTMnet; Q60891; -.
DR   PhosphoSitePlus; Q60891; -.
DR   PaxDb; Q60891; -.
DR   PRIDE; Q60891; -.
DR   Ensembl; ENSMUST00000050678; ENSMUSP00000049558; ENSMUSG00000047444.
DR   Ensembl; ENSMUST00000206280; ENSMUSP00000146141; ENSMUSG00000047444.
DR   GeneID; 259005; -.
DR   KEGG; mmu:259005; -.
DR   UCSC; uc007kbj.1; mouse.
DR   CTD; 259005; -.
DR   MGI; MGI:2177522; Olfr139.
DR   eggNOG; ENOG410IF69; Eukaryota.
DR   eggNOG; ENOG4111EH9; LUCA.
DR   GeneTree; ENSGT00840000129832; -.
DR   HOGENOM; HOG000041364; -.
DR   HOVERGEN; HBG017625; -.
DR   InParanoid; Q60891; -.
DR   KO; K04257; -.
DR   OMA; GICCTIS; -.
DR   OrthoDB; EOG091G0AZH; -.
DR   PhylomeDB; Q60891; -.
DR   TreeFam; TF352732; -.
DR   PRO; PR:Q60891; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   CleanEx; MM_OLFR1; -.
DR   GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISA:MGI.
DR   GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
KW   Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    315       Olfactory receptor 139.
FT                                /FTId=PRO_0000150816.
FT   TOPO_DOM      1     28       Extracellular. {ECO:0000255}.
FT   TRANSMEM     29     49       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     50     68       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     69     89       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     90     97       Extracellular. {ECO:0000255}.
FT   TRANSMEM     98    118       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    119    145       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    146    166       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    167    200       Extracellular. {ECO:0000255}.
FT   TRANSMEM    201    221       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    222    239       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    240    260       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    261    274       Extracellular. {ECO:0000255}.
FT   TRANSMEM    275    295       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    296    315       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD      8      8       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID    100    192       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   CONFLICT    146    146       T -> Q (in Ref. 6 and 7). {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        44    293       iprf:G_PROTEIN_RECEP_F1_2 [T]
FT   MYHIT       113    129       ipat:G_PROTEIN_RECEP_F1_1 [T]
SQ   SEQUENCE   315 AA;  34425 MW;  C82ED163C9DFD792 CRC64;
     MEPGAWGNRT AVTDFILLGL TGNVRLQPIL FVVFFFAYIV TVGGNLSILA AIFVEPKLHT
     PMYYFLGNLS LLDIGCISVT VPPMLVCLLA HECRVPYAAC ISQLFFFHLL AGVDCHLLTA
     MAYDRYLAIC QPLTYSTRMS REVQGTLVGI CCTVSFINAL THTVAVSVLD FCGPNVVNHF
     YCDLPPLFQL SCSSIYLNGQ LLFVGATFMG VVPMILISVS YAHVAAAVLR IRSTEGRKKA
     FSTCGSHLTV VCIFYGTGFF SYMRLGSVSA SDKDKGIGIL NTILSPMLNP LIYSLRNPDV
     QGALKRVLTG KRYPV
//