ID NEPR1_BOVIN Reviewed; 125 AA.
AC Q3ZBP2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 02-NOV-2016, entry version 69.
DE RecName: Full=Nuclear envelope phosphatase-regulatory subunit 1;
DE AltName: Full=Transmembrane protein 188;
GN Name=CNEP1R1; Synonyms=TMEM188;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Forms with the serine/threonine protein phosphatase
CC CTDNEP1 an active complex which dephosphorylates and may activate
CC LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases
CC that catalyze the conversion of phosphatidic acid to
CC diacylglycerol and control the metabolism of fatty acids at
CC differents levels. May indirectly modulate the lipid composition
CC of nuclear and/or endoplasmic reticulum membranes and be required
CC for proper nuclear membrane morphology and/or dynamics. May also
CC indirectly regulate the production of lipid droplets and
CC triacylglycerol (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CTDNEP1; the complex dephosphorylates
CC LPIN1 and LPIN2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Filamentous pattern in the cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CNEP1R1 family. {ECO:0000305}.
DR EMBL; BC103188; AAI03189.1; -; mRNA.
DR RefSeq; NP_001029475.1; NM_001034303.2.
DR UniGene; Bt.65363; -.
DR ProteinModelPortal; Q3ZBP2; -.
DR STRING; 9913.ENSBTAP00000044208; -.
DR PaxDb; Q3ZBP2; -.
DR Ensembl; ENSBTAT00000046962; ENSBTAP00000044208; ENSBTAG00000033078.
DR GeneID; 507593; -.
DR KEGG; bta:507593; -.
DR CTD; 255919; -.
DR eggNOG; KOG4606; Eukaryota.
DR eggNOG; ENOG4111N81; LUCA.
DR GeneTree; ENSGT00390000008576; -.
DR HOGENOM; HOG000285924; -.
DR HOVERGEN; HBG107287; -.
DR InParanoid; Q3ZBP2; -.
DR OMA; WIHPVFT; -.
DR OrthoDB; EOG091G19Y2; -.
DR TreeFam; TF313179; -.
DR Reactome; R-BTA-4419969; Depolymerisation of the Nuclear Lamina.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000033078; -.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0071595; C:Nem1-Spo7 phosphatase complex; ISS:UniProtKB.
DR GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; ISS:UniProtKB.
DR GO; GO:0010867; P:positive regulation of triglyceride biosynthetic process; ISS:UniProtKB.
DR GO; GO:0034504; P:protein localization to nucleus; ISS:UniProtKB.
DR InterPro; IPR019168; NEP1-R1.
DR Pfam; PF09771; Tmemb_18A; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Complete proteome; Cytoplasm; Lipid metabolism; Membrane;
KW Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 125 Nuclear envelope phosphatase-regulatory
FT subunit 1.
FT /FTId=PRO_0000286614.
FT TRANSMEM 33 53 Helical. {ECO:0000255}.
FT TRANSMEM 65 85 Helical. {ECO:0000255}.
FT MOD_RES 1 1 N-acetylmethionine.
FT {ECO:0000250|UniProtKB:Q8N9A8}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 6 122 ipfam:Tmemb_18A [T]
SQ SEQUENCE 125 AA; 14267 MW; 546EB9BEFE8EA593 CRC64;
MNSLEQAEDL KAFERRLTEY IHCLQPATGR WRMLLIVVSV CTATGAWNWL IDPETQKVSF
FTSLWNHPFF TISCITLIGL FFAGIHKRVV APSIIAARCR TVLAEYNMSC DDTGKLILKP
RPHVQ
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