ID MENH_ENT38 Reviewed; 258 AA.
AC A4WCP8;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 02-NOV-2016, entry version 62.
DE RecName: Full=2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase {ECO:0000255|HAMAP-Rule:MF_01660};
DE Short=SHCHC synthase {ECO:0000255|HAMAP-Rule:MF_01660};
DE EC=4.2.99.20 {ECO:0000255|HAMAP-Rule:MF_01660};
GN Name=menH {ECO:0000255|HAMAP-Rule:MF_01660};
GN OrderedLocusNames=Ent638_2813;
OS Enterobacter sp. (strain 638).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Enterobacter.
OX NCBI_TaxID=399742;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=638;
RX PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA Vangronsveld J., Newman L., Monchy S.;
RT "Genome sequence of the plant growth promoting endophytic bacterium
RT Enterobacter sp. 638.";
RL PLoS Genet. 6:E1000943-E1000943(2010).
CC -!- FUNCTION: Catalyzes a proton abstraction reaction that results in
CC 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-
CC hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of
CC 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
CC {ECO:0000255|HAMAP-Rule:MF_01660}.
CC -!- CATALYTIC ACTIVITY: 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-
CC ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-
CC diene-1-carboxylate + pyruvate. {ECO:0000255|HAMAP-Rule:MF_01660}.
CC -!- PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate
CC biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step
CC 3/7. {ECO:0000255|HAMAP-Rule:MF_01660}.
CC -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_01660}.
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_01660}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. MenH family.
CC {ECO:0000255|HAMAP-Rule:MF_01660}.
DR EMBL; CP000653; ABP61478.1; -; Genomic_DNA.
DR RefSeq; WP_015959811.1; NC_009436.1.
DR ProteinModelPortal; A4WCP8; -.
DR STRING; 399742.Ent638_2813; -.
DR ESTHER; ent38-menh; MenH_SHCHC.
DR MEROPS; S33.996; -.
DR EnsemblBacteria; ABP61478; ABP61478; Ent638_2813.
DR KEGG; ent:Ent638_2813; -.
DR PATRIC; 20415289; VBIEntSp101211_2963.
DR eggNOG; ENOG4107J5P; Bacteria.
DR eggNOG; COG0596; LUCA.
DR HOGENOM; HOG000028072; -.
DR KO; K08680; -.
DR OMA; LNDWYQQ; -.
DR UniPathway; UPA00079; -.
DR UniPathway; UPA01057; UER00900.
DR Proteomes; UP000000230; Chromosome.
DR GO; GO:0070205; F:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity; IEA:UniProtKB-HAMAP.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-HAMAP.
DR Gene3D; 3.40.50.1820; -; 1.
DR HAMAP; MF_01660; MenH; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR022485; SHCHC_synthase_MenH.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
DR TIGRFAMs; TIGR03695; menH_SHCHC; 1.
PE 3: Inferred from homology;
KW Complete proteome; Lyase; Menaquinone biosynthesis;
KW Reference proteome.
FT CHAIN 1 258 2-succinyl-6-hydroxy-2,4-cyclohexadiene-
FT 1-carboxylate synthase.
FT /FTId=PRO_0000341903.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 14 251 ihamap:MenH [T]
FT MYHIT 17 244 ipfam:Abhydrolase_6 [T]
SQ SEQUENCE 258 AA; 28379 MW; C812BBA2C7F469C1 CRC64;
MILNGKTRAG KPGFPWLVFL HGFSGDSREW QDVGAQLPDY PQLHLDLPGH GDSANIAVAG
FDEVSQLLAD TLVSYNILKF WLVGYSLGGR IAMFHACQHP AGLIGLIVEG GHPGLHDEPT
RKARAESDAQ WAERFRREPL ENVFSAWYQQ PVFAALQETE RDALVALRSQ NNGAALGAML
QATSLAQQPD LRAALRAHDY PFHYVYGEHD DKFGAIATEL TAQRHVIPNA GHNAHRENPA
AVAACLAQIL RLRIKDIP
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