Entry sw:MDTC_SERP5

ID   MDTC_SERP5              Reviewed;        1026 AA.
AC   A8GHR0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   18-JAN-2017, entry version 59.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   OrderedLocusNames=Spro_3554;
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=399741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=568;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Taghavi S., Newman L., Vangronsveld J., van der Lelie D.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB
CC       and MdtC. MdtC forms a heteromultimer with MdtB.
CC       {ECO:0000255|HAMAP-Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division
CC       (RND) (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
DR   EMBL; CP000826; ABV42650.1; -; Genomic_DNA.
DR   RefSeq; WP_012146263.1; NC_009832.1.
DR   ProteinModelPortal; A8GHR0; -.
DR   STRING; 399741.Spro_3554; -.
DR   EnsemblBacteria; ABV42650; ABV42650; Spro_3554.
DR   KEGG; spe:Spro_3554; -.
DR   PATRIC; 32419912; VBISerPro44537_3613.
DR   eggNOG; ENOG4105BZS; Bacteria.
DR   eggNOG; COG0841; LUCA.
DR   HOGENOM; HOG000158127; -.
DR   KO; K07789; -.
DR   OMA; MFVINSD; -.
DR   OrthoDB; POG091H01EK; -.
DR   Proteomes; UP000007074; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005215; F:transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1   1026       Multidrug resistance protein MdtC.
FT                                /FTId=PRO_1000068509.
FT   TRANSMEM     12     32       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01424}.
FT   TRANSMEM    333    353       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01424}.
FT   TRANSMEM    360    380       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01424}.
FT   TRANSMEM    387    407       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01424}.
FT   TRANSMEM    431    451       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01424}.
FT   TRANSMEM    463    483       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01424}.
FT   TRANSMEM    528    548       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01424}.
FT   TRANSMEM    853    873       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01424}.
FT   TRANSMEM    897    917       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01424}.
FT   TRANSMEM    953    973       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01424}.
FT   TRANSMEM    984   1004       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01424}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT         1   1024       ihamap:MdtC [T]
FT   MYHIT         4   1008       ipfam:ACR_tran [T]
SQ   SEQUENCE   1026 AA;  110882 MW;  C74001486ED8A216 CRC64;
     MKFFALFIYR PVATTLLTLA IAISGVISFS LLPVSPLPQV DYPVISISAS LPGADPETMA
     SSVATPLERA LGRIAGVNEM TSMSSLGSTR VILQFDLDRD INGAARDVQA AINAAQSLLP
     TGMPSRPSYR KVNPSDAPIM ILTLTSDTYS QGQLYDFAST QLAQKIAQTE GVGDVSVGGS
     SLPAVRVELN PSALFNQGIS LDAVRQTISN ANVRRPQGSV ENQQQRWQIQ ANDELKTAEV
     YRPLIIHYNN GSAVRLSDVA EVNDSVQDVR NAGMTNAKPA IILTISRAPD ANIIETVDRI
     RAELPTLQNN IPASIQLNIA QDRSPTIRAS LAEVEQSLVI AIGLVILVVF IFLRSGRATL
     IPAVAVPVSL IGSFTAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHIEAGMKP
     INAALVGVRE VGFTVLSMSV SLVAVFIPLL LMEGLPGRLF REFAVTLSVS IGLSLIISLT
     LTPMMCAYLL RHQPPRSQRR IRGFGKMLLA LQKGYGRSLS WVLGHSRWVL AVFLATIALN
     VWLYVSIPKT FFPEQDTGRL MGFIQADQSI SFQAMRVKLE DFMKIVREDP DVDNVTGFTG
     GSRTNSGSMF ISLKPLSVRS DDAQKVIARL RAKLAKEPGA SLFLMAVQDI RVGGRQANAS
     YQYTLMADDL AALREWEPKI RTALAALPEL ADVNSDQQDK GSEMDLVYDR ETMARLGISV
     SDANNLLNNA FGQRQISTIY QPLNQYKVVM EVAPPYTQDV SSLDKMFVIN SDGKAIPLSY
     FASWRPANAP LSVNHQGLSA ASTISFNLPD GGSLSDATAG IERTMTALGV PATVRGAFAG
     TAQVFQETLK SQLLLIAAAI ATVYIVLGIL YESYIHPLTI LSTLPSAGVG ALLALELFGA
     PFSLIALIGI MLLIGIVKKN AIMMVDFALD AQRNGGISAH DAIFQACLLR FRPIMMTTLA
     ALFGALPLVL THGDGAELRQ PLGITIVGGL IVSQLLTLYT TPVVYLYFDR LQMKFRRGKK
     LDPLPQ
//