Legends: 1, TOPO_DOM Cytoplasmic. {ECO:0000255}; 2, TRANSMEM Helical. {ECO:0000255|PROSITE- ProRule:PRU00441}; 3, TOPO_DOM Periplasmic. {ECO:0000255}; 4, ABC transmembrane type-1. {ECO:0000255|PROSITE-ProRule:PRU00441}; 5, ABC transporter. {ECO:0000255|PROSITE- ProRule:PRU00434}; 6, NP_BIND ATP. {ECO:0000255|PROSITE- ProRule:PRU00434}; 7, ipat:ABC_TRANSPORTER_1 [T].
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ID MDLB_ECOL6 Reviewed; 593 AA.
AC P0AAG6; P30751; P75706; P77117;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 02-NOV-2016, entry version 76.
DE RecName: Full=Multidrug resistance-like ATP-binding protein MdlB;
DE EC=3.6.3.44;
GN Name=mdlB; OrderedLocusNames=c0566;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P.,
RA Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D.,
RA Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T.,
RA Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence
RT of uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- CATALYTIC ACTIVITY: ATP + H(2)O + xenobiotic(In) = ADP + phosphate
CC + xenobiotic(Out).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Drug
CC exporter-2 (TC 3.A.1.117) family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 1 ABC transmembrane type-1 domain.
CC {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Contains 1 ABC transporter domain.
CC {ECO:0000255|PROSITE-ProRule:PRU00434}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN79044.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR EMBL; AE014075; AAN79044.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001256201.1; NC_004431.1.
DR ProteinModelPortal; P0AAG6; -.
DR SMR; P0AAG6; -.
DR STRING; 199310.c0566; -.
DR EnsemblBacteria; AAN79044; AAN79044; c0566.
DR KEGG; ecc:c0566; -.
DR PATRIC; 18279172; VBIEscCol75197_0531.
DR eggNOG; ENOG4105BZ1; Bacteria.
DR eggNOG; COG1132; LUCA.
DR KO; K18890; -.
DR OMA; IVMIIYQ; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008559; F:xenobiotic-transporting ATPase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR003439; ABC_transporter-like.
DR InterPro; IPR017871; ABC_transporter_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Complete proteome;
KW Hydrolase; Membrane; Nucleotide-binding; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 593 Multidrug resistance-like ATP-binding
FT protein MdlB.
FT /FTId=PRO_0000092498.
FT TOPO_DOM 1 25 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 26 46 Helical. {ECO:0000255|PROSITE-
FT ProRule:PRU00441}.
FT TOPO_DOM 47 62 Periplasmic. {ECO:0000255}.
FT TRANSMEM 63 83 Helical. {ECO:0000255|PROSITE-
FT ProRule:PRU00441}.
FT TOPO_DOM 84 140 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 141 161 Helical. {ECO:0000255|PROSITE-
FT ProRule:PRU00441}.
FT TOPO_DOM 162 164 Periplasmic. {ECO:0000255}.
FT TRANSMEM 165 185 Helical. {ECO:0000255|PROSITE-
FT ProRule:PRU00441}.
FT TOPO_DOM 186 254 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 255 275 Helical. {ECO:0000255|PROSITE-
FT ProRule:PRU00441}.
FT TOPO_DOM 276 278 Periplasmic. {ECO:0000255}.
FT TRANSMEM 279 299 Helical. {ECO:0000255|PROSITE-
FT ProRule:PRU00441}.
FT TOPO_DOM 300 593 Cytoplasmic. {ECO:0000255}.
FT DOMAIN 25 310 ABC transmembrane type-1.
FT {ECO:0000255|PROSITE-ProRule:PRU00441}.
FT DOMAIN 341 574 ABC transporter. {ECO:0000255|PROSITE-
FT ProRule:PRU00434}.
FT NP_BIND 374 381 ATP. {ECO:0000255|PROSITE-
FT ProRule:PRU00434}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 341 574 iprf:ABC_TRANSPORTER_2 [T]
FT MYHIT 26 295 ipfam:ABC_membrane [T]
FT MYHIT 27 310 iprf:ABC_TM1F [T]
FT MYHIT 366 557 ismart:AAA [T]
FT MYHIT 477 491 ipat:ABC_TRANSPORTER_1 [T]
FT MYHIT 357 505 ipfam:ABC_tran [T]
SQ SEQUENCE 593 AA; 65222 MW; CF1EE70009EB05D8 CRC64;
MRSFSQLWPT LKRLLAYGSP WRKPLGIAVL MMWVAAAAEV SGPLLISYFI DNMVAKNNLP
LKVVAGLAAA YVGLQLFAAG LHYAQSLLFN RAAVGVVQQL RTDVMDAALR QPLSEFDTQP
VGQVISRVTN DTEVIRDLYV TVVATVLRSA ALVGAMLVAM FSLDWRMALV AIMIFPVVLV
VMVIYQRYST PIVRRVRAYL ADINDGFNEI INGMSVIQQF RQQARFGERM GEASRSHYMA
RMQTLRLDGF LLRPLLSLFS SLILCGLLML FGFSASGTIE VGVLYAFISY LGRLNEPLIE
LTTQQAMLQQ AVVAGERVFE LMDGPRQQYG NDDRPLQSGT IEVDNVSFAY RDDNLVLKNI
NLSVPSRNFV ALVGHTGSGK STLASLLMGY YPLTEGEIRL DGRPLSSLSH SALRQGVAMV
QQDPVVLADT FLANVTLGRD ISEERVWQAL ETVQLAELAR SMSDGIYTPL GEQGNNLSVG
QKQLLALARV LVETPQILIL DEATASIDSG TEQAIQHALA AVREHTTLVV IAHRLSTIVD
ADTILVLHRG QAVEQGTHQQ LLAAQGRYWQ MYQLQLAGEE LAASVREEES LSA
//
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