We'd like to inform you that we have updated our Privacy Notice.
Do not show this banner again
user: GUEST
width: 600



DescriptionRecName: Full=Intraflagellar transport protein 172 homolog; AltName: Full=Selective LIM-binding factor;
MyHits logo
MyHits synonymsIF172_RAT , Q9JKU3 , B72C79207F5C0AA5
match map segment
ismart:WD40 ismart:WD40 ismart:WD40 ismart:WD40 ismart:WD40 ipfam:WD40 ismart:WD40 ismart:WD40  
Legends: 1, N-acetylmethionine. {ECO:0000250|UniProtKB:Q9UG01}; 2, Omega-N-methylarginine. {ECO:0000250|UniProtKB:Q6VH22}; 3, CROSSLNK Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1). {ECO:0000250|UniProtKB:Q9UG01}; 4, REPEAT WD 1; 5, REPEAT WD 2; 6, REPEAT WD 3; 7, REPEAT WD 4; 8, REPEAT WD 5; 9, REPEAT WD 6; 10, REPEAT WD 7; 11, REPEAT WD 8; 12, REPEAT WD 9; 13, REPEAT TPR 1; 14, REPEAT TPR 2; 15, REPEAT TPR 3; 16, REPEAT TPR 4; 17, REPEAT TPR 5; 18, REPEAT TPR 6; 19, REPEAT TPR 7; 20, REPEAT TPR 8; 21, REPEAT TPR 9; 22, REPEAT TPR 10; 23, REPEAT TPR 11; 24, REPEAT TPR 12; 25, REPEAT TPR 13; 26, REPEAT TPR 14; 27, ismart:WD40 [T]; 28, ipfam:WD40 [T].
ID   IF172_RAT               Reviewed;        1749 AA.
AC   Q9JKU3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   18-JAN-2017, entry version 104.
DE   RecName: Full=Intraflagellar transport protein 172 homolog;
DE   AltName: Full=Selective LIM-binding factor;
GN   Name=Ift172; Synonyms=Slb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, POSSIBLE INTERACTION
RP   WITH LHX3 AND LHX4, AND TISSUE SPECIFICITY.
RX   PubMed=10788441; DOI=10.1074/jbc.275.18.13336;
RA   Howard P.W., Maurer R.A.;
RT   "Identification of a conserved protein that interacts with specific
RT   LIM homeodomain transcription factors.";
RL   J. Biol. Chem. 275:13336-13342(2000).
CC   -!- FUNCTION: Required for the maintenance and formation of cilia.
CC       Plays an indirect role in hedgehog (Hh) signaling, cilia being
CC       required for all activity of the hedgehog pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IFT88 (By similarity). Interacts with
CC       RABL2/RABL2A; binds preferentially to GDP-bound RABL2 (By
CC       similarity). May interact with LHX3 and LHX4; the relevance of
CC       such interaction is however unclear in vivo. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC       Nucleus {ECO:0000269|PubMed:10788441}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the testis and pituitary
CC       cells. {ECO:0000269|PubMed:10788441}.
CC   -!- SIMILARITY: Belongs to the IFT172 family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 14 TPR repeats. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 9 WD repeats. {ECO:0000305}.
DR   EMBL; AF226993; AAF68274.1; -; mRNA.
DR   RefSeq; NP_446244.1; NM_053792.1.
DR   UniGene; Rn.171849; -.
DR   ProteinModelPortal; Q9JKU3; -.
DR   iPTMnet; Q9JKU3; -.
DR   PhosphoSitePlus; Q9JKU3; -.
DR   PRIDE; Q9JKU3; -.
DR   GeneID; 116475; -.
DR   KEGG; rno:116475; -.
DR   CTD; 26160; -.
DR   RGD; 620744; Ift172.
DR   HOVERGEN; HBG098449; -.
DR   InParanoid; Q9JKU3; -.
DR   KO; K19676; -.
DR   PhylomeDB; Q9JKU3; -.
DR   PRO; PR:Q9JKU3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:RGD.
DR   GO; GO:0008134; F:transcription factor binding; IDA:RGD.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:RGD.
DR   Gene3D; 2.120.10.30; -; 2.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cell projection; Cilium; Complete proteome;
KW   Developmental protein; Isopeptide bond; Methylation; Nucleus;
KW   Reference proteome; Repeat; TPR repeat; Ubl conjugation; WD repeat.
FT   CHAIN         1   1749       Intraflagellar transport protein 172
FT                                homolog.
FT                                /FTId=PRO_0000328943.
FT   REPEAT       14     53       WD 1.
FT   REPEAT       64    103       WD 2.
FT   REPEAT      110    148       WD 3.
FT   REPEAT      150    191       WD 4.
FT   REPEAT      195    233       WD 5.
FT   REPEAT      238    278       WD 6.
FT   REPEAT      284    323       WD 7.
FT   REPEAT      483    520       WD 8.
FT   REPEAT      521    559       WD 9.
FT   REPEAT      593    624       TPR 1.
FT   REPEAT      692    725       TPR 2.
FT   REPEAT      809    842       TPR 3.
FT   REPEAT      854    887       TPR 4.
FT   REPEAT      912    945       TPR 5.
FT   REPEAT      947    970       TPR 6.
FT   REPEAT      971   1004       TPR 7.
FT   REPEAT     1042   1075       TPR 8.
FT   REPEAT     1142   1175       TPR 9.
FT   REPEAT     1276   1309       TPR 10.
FT   REPEAT     1345   1378       TPR 11.
FT   REPEAT     1411   1445       TPR 12.
FT   REPEAT     1447   1477       TPR 13.
FT   REPEAT     1574   1607       TPR 14.
FT   MOD_RES       1      1       N-acetylmethionine.
FT                                {ECO:0000250|UniProtKB:Q9UG01}.
FT   MOD_RES     672    672       Omega-N-methylarginine.
FT                                {ECO:0000250|UniProtKB:Q6VH22}.
FT   CROSSLNK      4      4       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO1).
FT                                {ECO:0000250|UniProtKB:Q9UG01}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       186    223       ismart:WD40 [T]
FT   MYHIT         2     44       ismart:WD40 [T]
FT   MYHIT       225    267       ismart:WD40 [T]
FT   MYHIT       141    180       ismart:WD40 [T]
FT   MYHIT        55     94       ismart:WD40 [T]
FT   MYHIT        15     44       ipfam:WD40 [T]
FT   MYHIT       102    139       ismart:WD40 [T]
FT   MYHIT       279    314       ismart:WD40 [T]
SQ   SEQUENCE   1749 AA;  197603 MW;  B72C79207F5C0AA5 CRC64;
     MQLKHLRTLL SPQDGAAKVT CMAWSQNNAK FAVCTVDRVV LLYDEHGERR DKFSTKPADM
     KYGRKSYMVK GMAFSPDSTK IAIGQTDNII YVYKIGEDWG DKKVICNKFI QTSAVTCLQW
     PAEYIIVFGL AEGKVRLANT KTNKSSTIYG TDSYVVALTT NCSGKGILSG HADGTIVRYF
     FDDEGSGESQ GKLVNHPCPP YALAWATNSI VAAGCDRRIV AYGKEGHVLQ TFDYSRDPQE
     REFTTAAASP GGQSVVLGSY DRLRVFNWSP RRSIWEEAKP KEIANLYTVT ALAWKRDGSR
     LCAGTLCGGV EQFDCCLRRS IYKNKFELTY VGPSQLIVKN LSSGTRVVLK SHYGYEVEEV
     KILGKERYLV AHTSDTLLLG DLNTNRLSEI PWQGSGGNEK YFFENENVCM IFNAGELTLV
     EYGSNDSLGS VRTEFMNPHL ISVRINERCQ RGMEDNKKLA YLVDIKTIAI VDLIGGYNIG
     TISHESRVDW LELNETGHKL LFRDRKLRLH LYDIESCSKT MILNFCSYVQ WVPGSDVLVA
     QNRNSLCVWY NIEAPERVTM SSIRGDVVGL ERGGGKTEVM VTEGVTTVAY TLDEGLIEFG
     TAIDDGNYTR ATAFLETLEM TPETEAMWKT LSKLALEARQ LHTAERCFSA LGHVAKARFL
     HETNEIADQV SREYGGEGTD FYQVRARLAM LEKNYKLAEM IFLEQNAVEE AMDMYQELHR
     WDECIAVAEA KGHPALEKLR RDYYQRLMDT QQEERAGELQ ESQGDGLAAI SLYLKAGLPA
     KAARLVLTRE ELLANTELVE HITTALIKGE LYERAGDLFE KIRNPQRALE CYCKGNAFMK
     AVELARLAFP VEVVRLEEAW GDHLVQQKQL DAAINHYIEA RCSIKAIEAA LGARQWKKAI
     YILDLQDRNT ASKYYPRVAQ HYASLQEYEI AEELYTKGDR TKDAIDMYTQ AGRWEQAHKL
     AMKCMRPEDV SVLYITQAQE MEKQGKYREA ERLYVTVEEP DLAITMFKKH KLYDDMIRLV
     GKHHPDLLSD THLHLGKELE TEGRLQEAEY HYLEAQEWKA TVNMYRSSGL WEEAYRVAKA
     HGGANAHKHV AYLWAKSLGG EAAVRLLNKL GLLEAAIDHA ADNCSFEFAF ELSRLALKHK
     TPEIHLRYAM YLEDEGKFEE AEAEFIRAGK PKEAVLMFVH NQDWEAAQRV AEAHDPDSVA
     EVLVGQARGA LEEKDFQKAE GLLLRAQRPG LALNYYKEAG LWSDALRICK DYVPGQLEAL
     QEEYEREATK KGGRGVEGLV EQARQWEQAG EYSRAVDCYL KVRDSGSSGL MEKCWMKAAE
     LSIKFLPPQR SLEVVRVVGP QLIGIGKHSA SAELYLNLDL VKEAIDAFIE GEEWNKAKRV
     AKELDPRYED YVDQHYKEFL KNQGKVDSLV GVDVVAALDL YVEQGQWDKC IETATKQNYK
     ILHKYVALYA THLIREGGYA QALALYVQHG APANPQNFNI YKRIFTDMVS SPGTNNAEAY
     HSWADLRDVL FNLCENLVKS SEANSAAHEE FEMMLLIAHY YATRSAAQSI KQLETVAARL
     SVSLLRHTQL LPADKAFYEA GTAAKEVGWE NMAFIFFNRF LDLTDAIEEG TLDALDHSDF
     QDTDIPFEVP LPAKQHVPEA QREEVRDWVL TVSMDQRLEQ VLPRDERGVY EASLVAASTG
     VRALPCLITG YPILRNKIEF KRPGKAANKD NWNKFLMAIK TSHSPVCQDV LKFISQWCGG
     LPSTSFSFQ
//