ID HYCA_ECO57 Reviewed; 153 AA.
AC P0AEV5; P16427;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 02-NOV-2016, entry version 57.
DE RecName: Full=Formate hydrogenlyase regulatory protein HycA;
GN Name=hycA; OrderedLocusNames=Z4033, ECs3581;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA Welch R.A., Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli
RT O157:H7 and genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Regulatory protein for the formate hydrogenlyase system.
CC Could act by directly interacting with FhlA or by preventing the
CC binding of FhlA to the upstream activatory sequence (By
CC similarity). {ECO:0000250}.
DR EMBL; AE005174; AAG57832.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB37004.1; -; Genomic_DNA.
DR PIR; D85921; D85921.
DR PIR; E91076; E91076.
DR RefSeq; NP_311608.1; NC_002695.1.
DR RefSeq; WP_000158056.1; NZ_LPWC02000002.1.
DR ProteinModelPortal; P0AEV5; -.
DR STRING; 155864.Z4033; -.
DR EnsemblBacteria; AAG57832; AAG57832; Z4033.
DR EnsemblBacteria; BAB37004; BAB37004; BAB37004.
DR GeneID; 914697; -.
DR KEGG; ece:Z4033; -.
DR KEGG; ecs:ECs3581; -.
DR PATRIC; 18356629; VBIEscCol44059_3497.
DR eggNOG; ENOG4108VRC; Bacteria.
DR eggNOG; ENOG4111JXQ; LUCA.
DR HOGENOM; HOG000124058; -.
DR KO; K15833; -.
DR OMA; HAMSCAA; -.
DR BioCyc; ECOO157:HYCA-MONOMER; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR InterPro; IPR021285; Tscrpt_reg_HycA.
DR Pfam; PF11046; HycA_repressor; 1.
PE 3: Inferred from homology;
KW Complete proteome; Transcription; Transcription regulation.
FT CHAIN 1 153 Formate hydrogenlyase regulatory protein
FT HycA.
FT /FTId=PRO_0000084101.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 145 ipfam:HycA_repressor [T]
SQ SEQUENCE 153 AA; 17627 MW; CB61EC856450A0AD CRC64;
MTIWEISEKA DYIAQRHRRL QDQWHIYCNS LVQGITLSKA RLHHAMSCAP DKELCFVLFE
HFRIYVTLAD GFNSHTIEYY VETKDGEDKQ RIAQAQLSID GMIDGKVNIR DREQVLEHYL
EKIAGVYDSL YTAIENNVPV NLSQLVKGQS PAA
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