ID GP174_MOUSE Reviewed; 335 AA.
AC Q3U507;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 02-NOV-2016, entry version 93.
DE RecName: Full=Probable G-protein coupled receptor 174;
GN Name=Gpr174; Synonyms=Gm376;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=23178570; DOI=10.1016/j.bbrc.2012.11.046;
RA Sugita K., Yamamura C., Tabata K., Fujita N.;
RT "Expression of orphan G-protein coupled receptor GPR174 in CHO cells
RT induced morphological changes and proliferation delay via increasing
RT intracellular cAMP.";
RL Biochem. Biophys. Res. Commun. 430:190-195(2013).
CC -!- FUNCTION: Putative receptor for purines coupled to G-proteins.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in spleen and, at low levels, in
CC brain. {ECO:0000269|PubMed:23178570}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
DR EMBL; AK153611; BAE32116.1; -; mRNA.
DR EMBL; AK153950; BAE32273.1; -; mRNA.
DR EMBL; AK156069; BAE33570.1; -; mRNA.
DR EMBL; AK171832; BAE42688.1; -; mRNA.
DR CCDS; CCDS30348.1; -.
DR RefSeq; NP_001028423.1; NM_001033251.4.
DR RefSeq; NP_001171252.1; NM_001177781.1.
DR RefSeq; NP_001171253.1; NM_001177782.1.
DR UniGene; Mm.383562; -.
DR ProteinModelPortal; Q3U507; -.
DR STRING; 10090.ENSMUSP00000098852; -.
DR iPTMnet; Q3U507; -.
DR PhosphoSitePlus; Q3U507; -.
DR PaxDb; Q3U507; -.
DR PRIDE; Q3U507; -.
DR Ensembl; ENSMUST00000101294; ENSMUSP00000098852; ENSMUSG00000073008.
DR Ensembl; ENSMUST00000117310; ENSMUSP00000112808; ENSMUSG00000073008.
DR Ensembl; ENSMUST00000118820; ENSMUSP00000113032; ENSMUSG00000073008.
DR Ensembl; ENSMUST00000120971; ENSMUSP00000112974; ENSMUSG00000073008.
DR Ensembl; ENSMUST00000178838; ENSMUSP00000137372; ENSMUSG00000073008.
DR GeneID; 213439; -.
DR KEGG; mmu:213439; -.
DR UCSC; uc009ucd.2; mouse.
DR CTD; 84636; -.
DR MGI; MGI:2685222; Gpr174.
DR eggNOG; ENOG410IH6K; Eukaryota.
DR eggNOG; ENOG410ZJNT; LUCA.
DR GeneTree; ENSGT00760000118784; -.
DR HOGENOM; HOG000231258; -.
DR HOVERGEN; HBG099867; -.
DR InParanoid; Q3U507; -.
DR KO; K08391; -.
DR OMA; FTTDEFR; -.
DR OrthoDB; EOG091G0DAI; -.
DR PhylomeDB; Q3U507; -.
DR TreeFam; TF350009; -.
DR PRO; PR:Q3U507; -.
DR Proteomes; UP000000589; Chromosome X.
DR Bgee; ENSMUSG00000073008; -.
DR CleanEx; MM_GPR174; -.
DR Genevisible; Q3U507; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IC:MGI.
DR GO; GO:0045125; F:bioactive lipid receptor activity; IMP:MGI.
DR GO; GO:0043029; P:T cell homeostasis; IMP:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 335 Probable G-protein coupled receptor 174.
FT /FTId=PRO_0000069655.
FT TOPO_DOM 1 27 Extracellular. {ECO:0000255}.
FT TRANSMEM 28 48 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 49 53 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 54 74 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 75 91 Extracellular. {ECO:0000255}.
FT TRANSMEM 92 112 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 113 134 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 135 155 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 156 182 Extracellular. {ECO:0000255}.
FT TRANSMEM 183 203 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 204 231 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 232 252 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 253 268 Extracellular. {ECO:0000255}.
FT TRANSMEM 269 289 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 290 335 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 4 4 N-linked (GlcNAc...). {ECO:0000255}.
FT CARBOHYD 8 8 N-linked (GlcNAc...). {ECO:0000255}.
FT CARBOHYD 164 164 N-linked (GlcNAc...). {ECO:0000255}.
FT DISULFID 91 168 {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 36 292 ipfam:7tm_1 [T]
FT MYHIT 36 292 iprf:G_PROTEIN_RECEP_F1_2 [T]
SQ SEQUENCE 335 AA; 38761 MW; E1125388C0A7923D CRC64;
MTDNFTCNKT DGDNTDFRYF IYAVTYTVIL VPGLIGNILA LWVFYGYMKE TKRAVVFMIN
LAIADLLQIL SLPLRIFYYL NHDWPFGPGL CMFCFYLKYV NMYASIYFLV CISVRRFWFL
MYPFRFNDCK QKYDLYISII GWLIICLACL LFPLLRTNDD TPGNRTKCFV DLPIRNVNLA
QSVAMITIGE VVGFVTPLMI VLYCTWKTAL SLQNKYPISQ HLGEKKKALK MILTCAGVFL
VCFVPYHFSF PLDFLVKSNE IKSCFARRVI LIFHSVALCL ASLNSCLDPV IYYFTTNEFR
RRLSRQDLPD NIQLHTKSYK IASNHATSTV AAELC
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