MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Formate--tetrahydrofolate ligase {ECO:0000255|HAMAP-Rule:MF_01543}; EC=6.3.4.3 {ECO:0000255|HAMAP-Rule:MF_01543}; AltName: Full=Formyltetrahydrofolate synthetase {ECO:0000255|HAMAP-Rule:MF_01543}; Short=FHS {ECO:0000255|HAMAP-Rule:MF_01543}; Short=FTHFS {ECO:0000255|HAMAP-Rule:MF_01543}; |
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| MyHits synonyms | FTHS_CALBD , B9MM59 , 92CED9E624C09A5A |
 Legends: 1, NP_BIND ATP. {ECO:0000255|HAMAP-Rule:MF_01543}.
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ID FTHS_CALBD Reviewed; 552 AA.
AC B9MM59;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 02-NOV-2016, entry version 43.
DE RecName: Full=Formate--tetrahydrofolate ligase {ECO:0000255|HAMAP-Rule:MF_01543};
DE EC=6.3.4.3 {ECO:0000255|HAMAP-Rule:MF_01543};
DE AltName: Full=Formyltetrahydrofolate synthetase {ECO:0000255|HAMAP-Rule:MF_01543};
DE Short=FHS {ECO:0000255|HAMAP-Rule:MF_01543};
DE Short=FTHFS {ECO:0000255|HAMAP-Rule:MF_01543};
GN Name=fhs {ECO:0000255|HAMAP-Rule:MF_01543};
GN OrderedLocusNames=Athe_2208;
OS Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)
OS (Anaerocellum thermophilum).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacterales Family III. Incertae Sedis;
OC Caldicellulosiruptor.
OX NCBI_TaxID=521460;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1888 / DSM 6725 / Z-1320;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T.,
RA Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Ovchinnikova G., Kataeva I., Adams M.W.W.;
RT "Complete sequence of chromosome of Anaerocellum thermophilum DSM
RT 6725.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: ATP + formate + tetrahydrofolate = ADP +
CC phosphate + 10-formyltetrahydrofolate. {ECO:0000255|HAMAP-
CC Rule:MF_01543}.
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000255|HAMAP-Rule:MF_01543}.
CC -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase
CC family. {ECO:0000255|HAMAP-Rule:MF_01543}.
DR EMBL; CP001393; ACM61282.1; -; Genomic_DNA.
DR RefSeq; WP_015908543.1; NC_012034.1.
DR STRING; 521460.Athe_2208; -.
DR EnsemblBacteria; ACM61282; ACM61282; Athe_2208.
DR KEGG; ate:Athe_2208; -.
DR PATRIC; 20901682; VBIAnaThe135187_2326.
DR eggNOG; ENOG4105CKU; Bacteria.
DR eggNOG; COG2759; LUCA.
DR HOGENOM; HOG000040280; -.
DR KO; K01938; -.
DR OMA; CGEIMTM; -.
DR OrthoDB; POG091H01S8; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000007723; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-HAMAP.
DR GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00477; FTHFS; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_01543; FTHFS; 1.
DR InterPro; IPR000559; Formate_THF_ligase.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01268; FTHFS; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Ligase; Nucleotide-binding;
KW One-carbon metabolism.
FT CHAIN 1 552 Formate--tetrahydrofolate ligase.
FT /FTId=PRO_1000185243.
FT NP_BIND 63 70 ATP. {ECO:0000255|HAMAP-Rule:MF_01543}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 552 ihamap:FTHFS [T]
FT MYHIT 9 548 ipfam:FTHFS [T]
SQ SEQUENCE 552 AA; 59985 MW; 92CED9E624C09A5A CRC64;
MKSISKVEEV LEPISKIAEK IGLDEDEIEL YGKYKAKISL DILKKKAQLQ EGKVILVTSI
NPTPFGEGKT TTAIGLSMAI NRLGFKSIVT LREPSLGPFL GLKGGATGGG ASQILPSIDI
NLHFTGDIHA VTSANNLLCA AVDNHIYHGN RLGINPKSIT IKRAMDMNDR SLRHIIVGLS
NDQKGAIRED GFVISVASEV MAVLCLSMSY DDLKEKLGNI LVGFTYDKKP VYAKDLNVHG
SMALLLKDAL KPNLVQTSEN TAAIVHGGPF ANIAHGTNSI VATKIAQKLS EYVVVEAGFG
SDLGAEKFIN IVARKSGIYP QAAVLVVTVK ALKHHAKIEE NSGLQSGVNS IQQGLENLEK
HIENLKVMGL ETVVALNKFP DDKDEEIELI RSFCEEMGVE FSVSSAYTHG SEGVLELAEK
VIRLSDKRKR INFVYQDSDF IEEKIKKVAT IIYGAKDVKF SKAALSKLEL IKNLKVEHFP
ICMSKTQYSL SDDPKLLGKP KDFILNVTDI EIKNGAGFIV VMCGDIIAMP GLGKDFAALH
LDIDSSGNPI FK
//
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