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Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7

DescriptionRecName: Full=Ferric enterobactin transport protein FepE;
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MyHits synonymsFEPE_ECOLI , P26266 , Q2MBL4 , 1C81D51BBFC3A499
match map segment
ipfam:Wzz  
Legends: 1, TOPO_DOM Cytoplasmic. {ECO:0000255}; 2, TRANSMEM Helical. {ECO:0000255}. 
ID   FEPE_ECOLI              Reviewed;         377 AA.
AC   P26266; Q2MBL4;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 2.
DT   02-NOV-2016, entry version 120.
DE   RecName: Full=Ferric enterobactin transport protein FepE;
GN   Name=fepE; OrderedLocusNames=b0587, JW0579;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RA   Shea Cleavinger C.M., Ozenberger B., McIntosh M.;
RL   Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA   Mau B., Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains
RT   MG1655 and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-89.
RC   STRAIN=K12;
RX   PubMed=1826089; DOI=10.1021/bi00225a027;
RA   Rusnak F., Sakaitani M., Drueckhammer D., Reichert J., Walsh C.T.;
RT   "Biosynthesis of the Escherichia coli siderophore enterobactin:
RT   sequence of the entF gene, expression and purification of EntF, and
RT   analysis of covalent phosphopantetheine.";
RL   Biochemistry 30:2916-2927(1991).
RN   [6]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
RN   [7]
RP   OPERON STRUCTURE, AND INDUCTION.
RC   STRAIN=K12 / BW25113;
RX   PubMed=19429622; DOI=10.1128/JB.00108-09;
RA   Shimada T., Yamamoto K., Ishihama A.;
RT   "Involvement of the leucine response transcription factor LeuO in
RT   regulation of the genes for sulfa drug efflux.";
RL   J. Bacteriol. 191:4562-4571(2009).
CC   -!- FUNCTION: Part of the ferric enterobactin transport system.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC       protein.
CC   -!- INDUCTION: Repressed by H-NS, induced by LeuO. A monocistronic
CC       operon. {ECO:0000269|PubMed:19429622}.
CC   -!- SIMILARITY: Belongs to the WzzB/Cld/Rol family. {ECO:0000305}.
DR   EMBL; X74129; CAA52226.1; -; Genomic_DNA.
DR   EMBL; U82598; AAB40786.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC73688.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76342.1; -; Genomic_DNA.
DR   EMBL; M60177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; S34703; S34703.
DR   RefSeq; NP_415119.1; NC_000913.3.
DR   RefSeq; WP_000096692.1; NZ_LN832404.1.
DR   ProteinModelPortal; P26266; -.
DR   SMR; P26266; -.
DR   BioGrid; 4259898; 146.
DR   DIP; DIP-9596N; -.
DR   IntAct; P26266; 9.
DR   STRING; 511145.b0587; -.
DR   PaxDb; P26266; -.
DR   PRIDE; P26266; -.
DR   EnsemblBacteria; AAC73688; AAC73688; b0587.
DR   EnsemblBacteria; BAE76342; BAE76342; BAE76342.
DR   GeneID; 945180; -.
DR   KEGG; ecj:JW0579; -.
DR   KEGG; eco:b0587; -.
DR   PATRIC; 32116350; VBIEscCol129921_0615.
DR   EchoBASE; EB0293; -.
DR   EcoGene; EG10297; fepE.
DR   eggNOG; ENOG4108QY5; Bacteria.
DR   eggNOG; COG3765; LUCA.
DR   HOGENOM; HOG000117856; -.
DR   InParanoid; P26266; -.
DR   OMA; RKQDAVM; -.
DR   PhylomeDB; P26266; -.
DR   BioCyc; EcoCyc:EG10297-MONOMER; -.
DR   BioCyc; ECOL316407:JW0579-MONOMER; -.
DR   PRO; PR:P26266; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0015620; F:ferric-enterobactin transmembrane transporter activity; IMP:EcoCyc.
DR   GO; GO:0015685; P:ferric-enterobactin transport; IMP:EcoCyc.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR003856; LipoPS_biosynth.
DR   Pfam; PF02706; Wzz; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Complete proteome; Ion transport;
KW   Iron; Iron transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    377       Ferric enterobactin transport protein
FT                                FepE.
FT                                /FTId=PRO_0000087225.
FT   TOPO_DOM      1     41       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     42     62       Helical. {ECO:0000255}.
FT   TOPO_DOM     63    338       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    339    359       Helical. {ECO:0000255}.
FT   TOPO_DOM    360    377       Cytoplasmic. {ECO:0000255}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        25    122       ipfam:Wzz [T]
SQ   SEQUENCE   377 AA;  42100 MW;  1C81D51BBFC3A499 CRC64;
     MSSLNIKQGS DAHFPDYPLA SPSNNEIDLL NLISVLWRAK KTVMAVVFAF ACAGLLISFI
     LPQKWTSAAV VTPPEPVQWQ ELEKSFTKLR VLDLDIKIDR TEAFNLFIKK FQSVSLLEEY
     LRSSPYVMDQ LKEAKIDELD LHRAIVALSE KMKAVDDNAS KKKDEPSLYT SWTLSFTAPT
     SEEAQTVLSG YIDYISTLVV KESLENVRNK LEIKTQFEKE KLAQDRIKTK NQLDANIQRL
     NYSLDIANAA GIKKPVYSNG QAVKDDPDFS ISLGADGIER KLEIEKAVTD VAELNGELRN
     RQYLVEQLTK AHVNDVNFTP FKYQLSPSLP VKKDGPGKAI IVILSALIGG MVACGGVLLR
     YAMASRKQDA MMADHLV
//