ID FABD_ECOL6 Reviewed; 309 AA.
AC P0AAJ0; P25715;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 02-NOV-2016, entry version 75.
DE RecName: Full=Malonyl CoA-acyl carrier protein transacylase;
DE Short=MCT;
DE EC=2.3.1.39;
GN Name=fabD; OrderedLocusNames=c1361;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P.,
RA Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D.,
RA Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T.,
RA Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence
RT of uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- CATALYTIC ACTIVITY: Malonyl-CoA + an [acyl-carrier-protein] = CoA
CC + a malonyl-[acyl-carrier-protein].
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC -!- SIMILARITY: Belongs to the FabD family. {ECO:0000305}.
DR EMBL; AE014075; AAN79832.1; -; Genomic_DNA.
DR RefSeq; WP_000191372.1; NC_004431.1.
DR ProteinModelPortal; P0AAJ0; -.
DR SMR; P0AAJ0; -.
DR STRING; 199310.c1361; -.
DR EnsemblBacteria; AAN79832; AAN79832; c1361.
DR KEGG; ecc:c1361; -.
DR PATRIC; 18280737; VBIEscCol75197_1293.
DR eggNOG; ENOG4105CJF; Bacteria.
DR eggNOG; COG0331; LUCA.
DR HOGENOM; HOG000036503; -.
DR KO; K00645; -.
DR OMA; FHCALMQ; -.
DR BioCyc; ECOL199310:C1361-MONOMER; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.366.10; -; 2.
DR InterPro; IPR001227; Ac_transferase_dom.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR024925; Malonyl_CoA-ACP_transAc.
DR InterPro; IPR004410; Malonyl_CoA-ACP_transAc_FabD.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020801; PKS_acyl_transferase.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR PIRSF; PIRSF000446; Mct; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; SSF52151; 2.
DR SUPFAM; SSF55048; SSF55048; 1.
DR TIGRFAMs; TIGR00128; fabD; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Complete proteome; Fatty acid biosynthesis;
KW Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism;
KW Transferase.
FT INIT_MET 1 1 Removed. {ECO:0000250}.
FT CHAIN 2 309 Malonyl CoA-acyl carrier protein
FT transacylase.
FT /FTId=PRO_0000194215.
FT ACT_SITE 92 92 {ECO:0000250}.
FT ACT_SITE 201 201 {ECO:0000250}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 7 308 ismart:PKS_AT [T]
FT MYHIT 6 283 ipfam:Acyl_transf_1 [T]
SQ SEQUENCE 309 AA; 32417 MW; 3572E0681D14AB4A CRC64;
MTQFAFVFPG QGSQTVGMLA DMAASYPIVE ETFAEASAAL GYDLWALTQQ GPAEELNKTW
QTQPALLTAS VALYRVWQQQ GGKAPAMMAG HSLGEYSALV CAGVIDFADA VRLVEMRGKF
MQEAVPEGTG AMAAIIGLDD ASIAKACEEA AEGQVVSPVN FNSPGQVVIA GHKEAVERAG
AACKAAGAKR ALPLPVSVPS HCALMKPAAD KLAVELAKIT FNAPTVPVVN NVDVKCETNG
DAIRDALVRQ LYNPVQWTKS VEYMAAQGVE HLYEVGPGKV LTGLTKRIVD TLTASALNEP
SAMAAALEL
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