ID DRC3_CHLRE Reviewed; 524 AA.
AC A8IVX2;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 02-NOV-2016, entry version 51.
DE RecName: Full=Dynein regulatory complex subunit 3;
DE AltName: Full=Flagellar-associated protein 134;
GN Name=DRC3; Synonyms=FAP134; ORFNames=CHLREDRAFT_172483;
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; Chlorophyceae;
OC Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055 {ECO:0000312|Proteomes:UP000006906};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503 {ECO:0000312|Proteomes:UP000006906};
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K.,
RA Marechal-Drouard L., Marshall W.F., Qu L.H., Nelson D.R.,
RA Sanderfoot A.A., Spalding M.H., Kapitonov V.V., Ren Q., Ferris P.,
RA Lindquist E., Shapiro H., Lucas S.M., Grimwood J., Schmutz J.,
RA Cardol P., Cerutti H., Chanfreau G., Chen C.L., Cognat V., Croft M.T.,
RA Dent R., Dutcher S., Fernandez E., Fukuzawa H., Gonzalez-Ballester D.,
RA Gonzalez-Halphen D., Hallmann A., Hanikenne M., Hippler M., Inwood W.,
RA Jabbari K., Kalanon M., Kuras R., Lefebvre P.A., Lemaire S.D.,
RA Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L., Mittag M.,
RA Mittelmeier T., Moroney J.V., Moseley J., Napoli C., Nedelcu A.M.,
RA Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J., Purton S.,
RA Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L., Schroda M.,
RA Stern D., Umen J., Willows R., Wilson N., Zimmer S.L., Allmer J.,
RA Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P.,
RA Jorgensen R., Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T.,
RA Brokstein P., Dubchak I., Goodstein D., Hornick L., Huang Y.W.,
RA Jhaveri J., Luo Y., Martinez D., Ngau W.C., Otillar B., Poliakov A.,
RA Porter A., Szajkowski L., Werner G., Zhou K., Grigoriev I.V.,
RA Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and
RT plant functions.";
RL Science 318:245-250(2007).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY,
RP AND IDENTIFICATION IN THE THE N-DRC COMPLEX.
RX PubMed=26063732; DOI=10.1091/mbc.E15-01-0018;
RA Awata J., Song K., Lin J., King S.M., Sanderson M.J., Nicastro D.,
RA Witman G.B.;
RT "DRC3 connects the N-DRC to dynein g to regulate flagellar waveform.";
RL Mol. Biol. Cell 26:2788-2800(2015).
CC -!- FUNCTION: Key component of the nexin-dynein regulatory complex (N-
CC DRC). Requires for normal flagellar waveform.
CC {ECO:0000269|PubMed:26063732}.
CC -!- SUBUNIT: Found in a complex with DRC3, DRC4, DRC7 and DRC11
CC (PubMed:26063732). {ECO:0000269|PubMed:26063732}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:26063732}.
CC -!- SIMILARITY: Belongs to the DRC3 family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 7 LRR (leucine-rich) repeats. {ECO:0000255}.
DR EMBL; DS496125; EDP03601.1; -; Genomic_DNA.
DR RefSeq; XP_001693032.1; XM_001692980.1.
DR UniGene; Cre.7832; -.
DR ProteinModelPortal; A8IVX2; -.
DR STRING; 3055.EDP03601; -.
DR PaxDb; A8IVX2; -.
DR EnsemblPlants; EDP03601; EDP03601; CHLREDRAFT_172483.
DR GeneDB; Tb927.6.5030:pep; -.
DR GeneID; 5718572; -.
DR Gramene; EDP03601; EDP03601; CHLREDRAFT_172483.
DR KEGG; cre:CHLREDRAFT_172483; -.
DR eggNOG; KOG0531; Eukaryota.
DR eggNOG; COG4886; LUCA.
DR InParanoid; A8IVX2; -.
DR OMA; HQEAPSD; -.
DR Proteomes; UP000006906; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0060285; P:cilium-dependent cell motility; IMP:GeneDB.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; L_dom-like.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR SMART; SM00369; LRR_TYP; 3.
DR PROSITE; PS51450; LRR; 5.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm;
KW Cytoskeleton; Flagellum; Leucine-rich repeat; Reference proteome;
KW Repeat.
FT CHAIN 1 524 Dynein regulatory complex subunit 3.
FT /FTId=PRO_0000435304.
FT REPEAT 66 90 LRR 1. {ECO:0000255}.
FT REPEAT 92 110 LRR 2. {ECO:0000255}.
FT REPEAT 111 132 LRR 3. {ECO:0000255}.
FT REPEAT 133 155 LRR 4. {ECO:0000255}.
FT REPEAT 157 183 LRR 5. {ECO:0000255}.
FT REPEAT 250 275 LRR 6. {ECO:0000255}.
FT REPEAT 419 442 LRR 7. {ECO:0000255}.
FT COILED 198 247 {ECO:0000255}.
FT COILED 313 372 {ECO:0000255}.
FT COILED 450 514 {ECO:0000255}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 134 155 iprf:LRR [T]
FT MYHIT 66 87 ismart:LRR_TYP [T]
FT MYHIT 159 180 iprf:LRR [T]
FT MYHIT 112 133 iprf:LRR [T]
FT MYHIT 68 89 iprf:LRR [T]
FT MYHIT 132 155 ismart:LRR_TYP [T]
FT MYHIT 90 111 iprf:LRR [T]
FT MYHIT 88 110 ismart:LRR_TYP [T]
SQ SEQUENCE 524 AA; 60409 MW; 370669A342D6D463 CRC64;
MPSLERLIAE VEPNVITESL TRECIQIQGG EPDTAANKKR TMPFRDVECL AFSFKNLACV
DNLRGLDTLT KLQLDNNQIT KIENLAHLTN LTWLDLSFNK ITAISGLETL TKLVDLSLFN
NQIAKIENLD TLVNLNVLSL GNNQLSQLDN VMYLRQFKQL RLVNLAGNPI CKSHDYRSYV
LSHIKDLIYL DYRRVNPADV QAAREQHQDE MIELQEREEQ QSQEEKLNAE RESHEKLMKQ
ANLEGVETLI DDMVKEDLEW PRLSQVPSLL DPWNEIRDKF NTYTDEFKVA ILEQHNKKKA
EYEEWLGVVR SYLDEKDAEA RKLIVEYEKA KKRTARVVVD QPLMAESQID NLKVKLMALK
DQLMAIEMEA VEVLDGLVQE FDRAYSELAE INKGQYNGYF TQVRDLQNSF FNQLTSVAMT
VFEKYNQENS DIESLPEEAR TLLQDKDSLM NALQASHDAH MGKIDSLEDR LVSNELRSAN
DLTSSNATWA TKRNRDRISE IINYLERNVL ELEELAGEEE GGEM
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