Entry sw:DPO3_STRPF

ID   DPO3_STRPF              Reviewed;        1465 AA.
AC   Q1J4M0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   02-NOV-2016, entry version 78.
DE   RecName: Full=DNA polymerase III PolC-type {ECO:0000255|HAMAP-Rule:MF_00356};
DE            Short=PolIII {ECO:0000255|HAMAP-Rule:MF_00356};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_00356};
GN   Name=polC {ECO:0000255|HAMAP-Rule:MF_00356};
GN   OrderedLocusNames=MGAS10750_Spy1766;
OS   Streptococcus pyogenes serotype M4 (strain MGAS10750).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=370554;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS10750;
RX   PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA   Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F.,
RA   DeLeo F.R., Musser J.M.;
RT   "Molecular genetic anatomy of inter- and intraserotype variation in
RT   the human bacterial pathogen group A Streptococcus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
CC   -!- FUNCTION: Required for replicative DNA synthesis. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity.
CC       {ECO:0000255|HAMAP-Rule:MF_00356}.
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1). {ECO:0000255|HAMAP-Rule:MF_00356}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00356}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. PolC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00356}.
CC   -!- SIMILARITY: Contains 1 exonuclease domain. {ECO:0000305}.
DR   EMBL; CP000262; ABF38716.1; -; Genomic_DNA.
DR   RefSeq; WP_011529023.1; NC_008024.1.
DR   ProteinModelPortal; Q1J4M0; -.
DR   EnsemblBacteria; ABF38716; ABF38716; MGAS10750_Spy1766.
DR   KEGG; spi:MGAS10750_Spy1766; -.
DR   PATRIC; 19729874; VBIStrPyo25933_1811.
DR   HOGENOM; HOG000058064; -.
DR   KO; K03763; -.
DR   OMA; QGCTGVK; -.
DR   OrthoDB; POG091H01BK; -.
DR   Proteomes; UP000002434; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.420.10; -; 1.
DR   HAMAP; MF_00356; DNApol_PolC; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha.
DR   InterPro; IPR024754; DNA_polC-like_N_II.
DR   InterPro; IPR028112; DNA_polC-type_N_I.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR006054; DnaQ.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR006308; PolC_gram_pos.
DR   InterPro; IPR012337; RNaseH-like_dom.
DR   Pfam; PF14480; DNA_pol3_a_NI; 1.
DR   Pfam; PF11490; DNA_pol3_a_NII; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00573; dnaq; 1.
DR   TIGRFAMs; TIGR01405; polC_Gram_pos; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA replication;
KW   DNA-directed DNA polymerase; Exonuclease; Hydrolase; Nuclease;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN         1   1465       DNA polymerase III PolC-type.
FT                                /FTId=PRO_1000048487.
FT   DOMAIN      427    583       Exonuclease.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       341    408       ismart:POLIIIAc [T]
FT   MYHIT       428    582       ipfam:RNase_T [T]
FT   MYHIT         1   1465       ihamap:DNApol_PolC [T]
FT   MYHIT       426    592       ismart:EXOIII [T]
FT   MYHIT        92    206       ipfam:DNA_pol3_a_NII [T]
FT   MYHIT      1378   1454       ipfam:HHH_6 [T]
FT   MYHIT       842   1270       ipfam:DNA_pol3_alpha [T]
FT   MYHIT       342    701       ipfam:PHP [T]
FT   MYHIT         5     78       ipfam:DNA_pol3_a_NI [T]
SQ   SEQUENCE   1465 AA;  164575 MW;  2F7949920BDE122C CRC64;
     MSDLFAKLMD QIEMPLDMRR SSAFSSADII EVKVHSVSRL WEFHFAFAAV LPIATYRELH
     DRLIRTFEAA DIKVTFDIQA AQVDYSDDLL QAYYQEAFEH APCNSASFKS SFSKLKVTYE
     DDKLIIAAPG FVNNDHFRNN HLPNLVKQFE AFGFGTLTID MVSDQEMTEH LTKDFVSSRQ
     ALVKKAVQDN LEAQKSLEAM MPPVEEATPA PKFDYKERAA KRQAGFEKAT ITPMIEIETE
     ENRIVFEGMV FDVERKTTRT GRHIINFKMT DYTSSFALQK WAKDDEELRK FDMIAKGAWL
     RVQGNIETNP FTKSLTMNVQ QVKEIVHHER KDLMPEGQKR VELHAHTNMS TMDALPTVES
     LIDTAAKWGH KAVAITDHAN VQSFPHGYHR ARKAGIKAIF GLEANIVEDK VPISYDPVDM
     DLHEATYVVF DVETTGLSAM NNDLIQIAAS KMFKGNIVEQ FDEFIDPGHP LSAFTTELTG
     ITDKHLQGAK PLVTVLKAFQ DFCKDSILVA HNASFDVGFM NANYERHDLP KITQPVIDTL
     EFARNLYPEY KRHGLGPLTK RFQVSLDHHH MANYDAEATG RLLFIFLKDA REKHGIKNLL
     QLNTDLVAED SYKKARIKHA TIYVQNQVGL KNMFKLVSLS NIKYFEGVPR IPRTVLDAHR
     EGLLLGTACS DGEVFDAVLT KGIDAAVDLA KYYDFIEIMP PAIYQPLVVR ELIKDQAGIE
     QVIRDLIEVG KRANKLVLAT GNVHYLEPEE EIYREIIVRS LGQGAMINRT IGRGEGAQPA
     PLPKAHFRTT NEMLDEFAFL GKDLAYQVVV ENTQDFADRI EEVEVVKGDL YTPYIDKAEE
     TVAELTYQKA FEIYGNPLPD IIDLRIEKEL TSILGNGFAV IYLASQMLVN RSNERGYLVG
     SRGSVGSSFV ATMIGITEVN PMPPHYVCPS CQHSEFITDG SVGSGYDLPN KPCPKCGTPY
     QKDGQDIPFE TFLGFDGDKV PDIDLNFSGD DQPSAHLDVR DIFGAEYAFR AGTVGTVAEK
     TAYGFVKGYE RDYGKFYRDA EVDRLAAGAA GVKRTTGQHP GGIVVIPNYM DVYDFTPVQY
     PADDVTASWQ TTHFNFHDID ENVLKLDILG HDDPTMIRKL QDLSGIDPIT IPADDPGVMA
     LFSGTEVLGV TPEQIGTPTG MLGIPEFGTN FVRGMVNETH PTTFAELLQL SGLSHGTDVW
     LGNAQDLIKE GIATLKTVIG CRDDIMVYLM HAGLEPKMAF TIMERVRKGL WLKISEEERN
     GYIDAMRENN VPDWYIESCG KIKYMFPKAH AAAYVLMALR VAYFKVHHPI MYYCAYFSIR
     AKAFELKTMS GGLDAVKARM EDITIKRKNN EATNVENDLF TTLEIVNEML ERGFKFGKLD
     LYKSDAIEFQ IKGDTLIPPF IALEGLGENV AKQIVKARQE GEFLSKMELR KRGGASSTLV
     EKMDEMGILG NMPEDNQLSL FDDFF
//