ID DB134_PANTR Reviewed; 59 AA.
AC Q30KJ5;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 07-SEP-2016, entry version 49.
DE RecName: Full=Beta-defensin 134;
DE AltName: Full=Defensin, beta 134;
DE Flags: Precursor;
GN Name=DEFB134;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the
RT male reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
DR EMBL; DQ012085; AAY59815.1; -; mRNA.
DR RefSeq; NP_001123260.1; NM_001129788.1.
DR UniGene; Ptr.6104; -.
DR ProteinModelPortal; Q30KJ5; -.
DR STRING; 9598.ENSPTRP00000055433; -.
DR PaxDb; Q30KJ5; -.
DR Ensembl; ENSPTRT00000063887; ENSPTRP00000055433; ENSPTRG00000031031.
DR GeneID; 737890; -.
DR KEGG; ptr:737890; -.
DR CTD; 613211; -.
DR eggNOG; ENOG410JFD3; Eukaryota.
DR eggNOG; ENOG41118XV; LUCA.
DR GeneTree; ENSGT00400000024366; -.
DR HOGENOM; HOG000112164; -.
DR HOVERGEN; HBG079896; -.
DR InParanoid; Q30KJ5; -.
DR OMA; FQLECCI; -.
DR OrthoDB; EOG091G14QD; -.
DR Proteomes; UP000002277; Chromosome 8.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Complete proteome; Defensin;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1 19 {ECO:0000255}.
FT CHAIN 20 59 Beta-defensin 134.
FT /FTId=PRO_0000045361.
FT DISULFID 25 51 {ECO:0000250}.
FT DISULFID 31 45 {ECO:0000250}.
FT DISULFID 35 52 {ECO:0000250}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 24 52 ipfam:Defensin_beta_2 [T]
SQ SEQUENCE 59 AA; 6893 MW; 2A2D0C6062D1A17A CRC64;
MKPLLVVFVF LFLWDPVLAE MHKKCYKNGI CRLECYESEM LVAYCMFQLE CCVKGNPAP
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