ID D103A_PONPY Reviewed; 67 AA.
AC A4H200;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 02-NOV-2016, entry version 33.
DE RecName: Full=Beta-defensin 103A;
DE AltName: Full=Defensin, beta 103;
DE AltName: Full=Defensin, beta 103A;
DE Flags: Precursor;
GN Name=DEFB103A; Synonyms=DEFB103;
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hollox E.J., Armour J.A.L.;
RT "Evolution and sequence variation of human beta-defensin genes.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Exhibits antimicrobial activity against Gram-positive
CC and Gram-negative bacteria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
DR EMBL; AM410105; CAL68920.1; -; Genomic_DNA.
DR ProteinModelPortal; A4H200; -.
DR SMR; A4H200; -.
DR HOGENOM; HOG000015465; -.
DR HOVERGEN; HBG004834; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Secreted; Signal.
FT SIGNAL 1 22 {ECO:0000250}.
FT PEPTIDE 23 67 Beta-defensin 103A.
FT /FTId=PRO_0000289807.
FT DISULFID 33 62 {ECO:0000250}.
FT DISULFID 40 55 {ECO:0000250}.
FT DISULFID 45 63 {ECO:0000250}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 30 64 ipfam:Defensin_beta [T]
SQ SEQUENCE 67 AA; 7697 MW; 54266DE1C90D4B65 CRC64;
MRIHYLLFAL LFLFLVPVPG HGGIINTLQK YYCRVRGGRC AVLSCLPKEE QIGKCSTRGR
KCCRRKK
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