ID D103A_PANTR Reviewed; 67 AA.
AC Q95JD2; A4H1Z8; Q30KM2; Q5IAC2;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 30-NOV-2016, entry version 78.
DE RecName: Full=Beta-defensin 103A;
DE AltName: Full=Beta-defensin 3;
DE Short=BD-3;
DE Short=DEFB-3;
DE Short=cBD-3;
DE AltName: Full=Defensin, beta 103;
DE AltName: Full=Defensin, beta 103A;
DE Flags: Precursor;
GN Name=DEFB103A; Synonyms=DEFB103, DEFB3;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the
RT male reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hollox E.J., Armour J.A.L.;
RT "Evolution and sequence variation of human beta-defensin genes.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-64.
RC TISSUE=Skin;
RA Duits L.A., Langermans J.A.M., Ravensbergen B., Paltansing S.,
RA Vervenne R.A.W., Hiemstra P.S., Thomas A.W., Nibbering P.H.;
RT "Expression of chimpanzee (Pan troglodytes) beta-defensin-3.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-67.
RX PubMed=15904491; DOI=10.1186/1471-2148-5-32;
RA Semple C.A.M., Maxwell A., Gautier P., Kilanowski F.M., Eastwood H.,
RA Barran P.E., Dorin J.R.;
RT "The complexity of selection at the major primate beta-defensin
RT locus.";
RL BMC Evol. Biol. 5:32-32(2005).
CC -!- FUNCTION: Exhibits antimicrobial activity against Gram-positive
CC and Gram-negative bacteria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
DR EMBL; DQ012056; AAY59788.1; -; mRNA.
DR EMBL; AM410103; CAL68918.1; -; Genomic_DNA.
DR EMBL; AY033883; AAK61549.1; -; mRNA.
DR EMBL; AY831729; AAW32910.1; -; Genomic_DNA.
DR RefSeq; NP_001123222.1; NM_001129750.1.
DR UniGene; Ptr.6294; -.
DR ProteinModelPortal; Q95JD2; -.
DR STRING; 9598.ENSPTRP00000034200; -.
DR PaxDb; Q95JD2; -.
DR Ensembl; ENSPTRT00000037006; ENSPTRP00000034200; ENSPTRG00000019964.
DR GeneID; 450106; -.
DR KEGG; ptr:450106; -.
DR CTD; 414325; -.
DR eggNOG; ENOG410JFYR; Eukaryota.
DR eggNOG; ENOG411134U; LUCA.
DR GeneTree; ENSGT00530000064280; -.
DR HOGENOM; HOG000015465; -.
DR HOVERGEN; HBG004834; -.
DR InParanoid; Q95JD2; -.
DR OMA; IRGGRCA; -.
DR OrthoDB; EOG091G16TA; -.
DR Proteomes; UP000002277; Chromosome 8.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Complete proteome; Defensin;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1 22 {ECO:0000250}.
FT PEPTIDE 23 67 Beta-defensin 103A.
FT /FTId=PRO_0000006972.
FT DISULFID 33 62 {ECO:0000250}.
FT DISULFID 40 55 {ECO:0000250}.
FT DISULFID 45 63 {ECO:0000250}.
FT CONFLICT 60 60 R -> Q (in Ref. 2; CAL68918).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 30 64 ipfam:Defensin_beta [T]
SQ SEQUENCE 67 AA; 7711 MW; 54516DE1C90D4B60 CRC64;
MRIHYLLFAL LFLFLVPVPG HGGIINTLQK YYCRVRGGRC AVLTCLPKEE QIGKCSTRGR
KCCRRKK
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