ID D103A_HORSE Reviewed; 67 AA.
AC Q0W9P9;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 05-OCT-2016, entry version 50.
DE RecName: Full=Beta-defensin 103A;
DE AltName: Full=Defensin, beta 103;
DE AltName: Full=Defensin, beta 103A;
DE Flags: Precursor;
GN Name=DEFB103A; Synonyms=DEFB103;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16723195; DOI=10.1016/j.gene.2006.03.006;
RA Looft C., Paul S., Philipp U., Regenhard P., Kuiper H., Distl O.,
RA Chowdhary B.P., Leeb T.;
RT "Sequence analysis of a 212 kb defensin gene cluster on ECA 27q17.";
RL Gene 376:192-198(2006).
CC -!- FUNCTION: Exhibits antimicrobial activity against Gram-positive
CC and Gram-negative bacteria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
DR EMBL; AM039964; CAJ01801.1; -; Genomic_DNA.
DR RefSeq; XP_003364293.1; XM_003364245.3.
DR ProteinModelPortal; Q0W9P9; -.
DR STRING; 9796.ENSECAP00000005162; -.
DR PaxDb; Q0W9P9; -.
DR Ensembl; ENSECAT00000007133; ENSECAP00000005162; ENSECAG00000007143.
DR GeneID; 100629456; -.
DR KEGG; ecb:100629456; -.
DR eggNOG; ENOG410JFYR; Eukaryota.
DR eggNOG; ENOG411134U; LUCA.
DR GeneTree; ENSGT00530000064280; -.
DR HOGENOM; HOG000015465; -.
DR HOVERGEN; HBG004834; -.
DR InParanoid; Q0W9P9; -.
DR OMA; IRGGRCA; -.
DR OrthoDB; EOG091G16TA; -.
DR Proteomes; UP000002281; Chromosome 27.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Complete proteome; Defensin;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1 22 {ECO:0000250}.
FT PEPTIDE 23 67 Beta-defensin 103A.
FT /FTId=PRO_0000289806.
FT DISULFID 33 62 {ECO:0000250}.
FT DISULFID 40 55 {ECO:0000250}.
FT DISULFID 45 63 {ECO:0000250}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 31 64 ipfam:Defensin_beta [T]
SQ SEQUENCE 67 AA; 7545 MW; 8C327B78E71DD7B7 CRC64;
MRIHFLLFAL LFLFLMPVPG NGGIINMLQK SYCKIRKGRC ALLGCLPKEE QIGSCSVSGR
KCCRKKK
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