ID CYOC_SHIFL Reviewed; 204 AA.
AC P0ABJ5; P18402;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 30-NOV-2016, entry version 79.
DE RecName: Full=Cytochrome bo(3) ubiquinol oxidase subunit 3;
DE AltName: Full=Cytochrome o ubiquinol oxidase subunit 3;
DE Short=Cytochrome o subunit 3;
DE AltName: Full=Oxidase bo(3) subunit 3;
DE AltName: Full=Ubiquinol oxidase chain C;
DE AltName: Full=Ubiquinol oxidase polypeptide III;
DE AltName: Full=Ubiquinol oxidase subunit 3;
GN Name=cyoC; OrderedLocusNames=SF0371, S0376;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H.,
RA Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J.,
RA Sun L., Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S.,
RA Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y.,
RA Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/IAI.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W.,
RA Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A.,
RA Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S.,
RA Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella
RT flexneri serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Cytochrome bo(3) ubiquinol terminal oxidase is the
CC component of the aerobic respiratory chain of E.coli that
CC predominates when cells are grown at high aeration. Has proton
CC pump activity across the membrane in addition to electron
CC transfer, pumping 2 protons/electron (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Heterooctamer of two A chains, two B chains, two C chains
CC and two D chains. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC {ECO:0000305}.
DR EMBL; AE005674; AAN42029.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP15906.1; -; Genomic_DNA.
DR RefSeq; NP_706322.1; NC_004337.2.
DR RefSeq; WP_000179819.1; NZ_LVJC01000170.1.
DR ProteinModelPortal; P0ABJ5; -.
DR STRING; 198214.SF0371; -.
DR PaxDb; P0ABJ5; -.
DR EnsemblBacteria; AAN42029; AAN42029; SF0371.
DR EnsemblBacteria; AAP15906; AAP15906; S0376.
DR GeneID; 1027694; -.
DR KEGG; sfl:SF0371; -.
DR KEGG; sft:NCTC1_00382; -.
DR KEGG; sfx:S0376; -.
DR PATRIC; 18701765; VBIShiFle31049_0415.
DR eggNOG; ENOG4105CCU; Bacteria.
DR eggNOG; COG1845; LUCA.
DR HOGENOM; HOG000086398; -.
DR KO; K02299; -.
DR OMA; YTELVKH; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008827; F:cytochrome o ubiquinol oxidase activity; IEA:InterPro.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR CDD; cd02863; Ubiquinol_oxidase_III; 1.
DR Gene3D; 1.20.120.80; -; 1.
DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR InterPro; IPR014206; Cyt_c_ubiqinol_oxidase_su3.
DR InterPro; IPR033946; Ubiquinol_oxase_su3_dom.
DR PANTHER; PTHR11403; PTHR11403; 1.
DR Pfam; PF00510; COX3; 1.
DR SUPFAM; SSF81452; SSF81452; 1.
DR TIGRFAMs; TIGR02842; CyoC; 1.
DR PROSITE; PS50253; COX3; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Complete proteome;
KW Electron transport; Membrane; Oxidoreductase; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 204 Cytochrome bo(3) ubiquinol oxidase
FT subunit 3.
FT /FTId=PRO_0000183895.
FT TOPO_DOM 1 31 Cytoplasmic. {ECO:0000305}.
FT TRANSMEM 32 50 Helical. {ECO:0000305}.
FT TOPO_DOM 51 66 Periplasmic. {ECO:0000305}.
FT TRANSMEM 67 85 Helical. {ECO:0000305}.
FT TOPO_DOM 86 101 Cytoplasmic. {ECO:0000305}.
FT TRANSMEM 102 120 Helical. {ECO:0000305}.
FT TOPO_DOM 121 142 Periplasmic. {ECO:0000305}.
FT TRANSMEM 143 161 Helical. {ECO:0000305}.
FT TOPO_DOM 162 184 Cytoplasmic. {ECO:0000305}.
FT TRANSMEM 185 203 Helical. {ECO:0000305}.
FT TOPO_DOM 204 204 Periplasmic. {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 203 iprf:COX3 [T]
FT MYHIT 16 202 ipfam:COX3 [T]
SQ SEQUENCE 204 AA; 22623 MW; F1D6ABF9EB6CB5AD CRC64;
MATDTLTHAT AHAHEHGHHD AGGTKIFGFW IYLMSDCILF SILFATYAVL VNGTAGGPTG
KDIFELPFVL VETFLLLFSS ITYGMAAIAM YKNNKSQVIS WLALTWLFGA GFIGMEIYEF
HHLIVNGMGP DRSGFLSAFF ALVGTHGLHV TSGLIWMAVL MVQIARRGLT STNRTRIMCL
SLFWHFLDVV WICVFTVVYL MGAM
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