ID CYOC_ECOL6 Reviewed; 204 AA.
AC P0ABJ4; P18402;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 30-NOV-2016, entry version 74.
DE RecName: Full=Cytochrome bo(3) ubiquinol oxidase subunit 3;
DE AltName: Full=Cytochrome o ubiquinol oxidase subunit 3;
DE Short=Cytochrome o subunit 3;
DE AltName: Full=Oxidase bo(3) subunit 3;
DE AltName: Full=Ubiquinol oxidase chain C;
DE AltName: Full=Ubiquinol oxidase polypeptide III;
DE AltName: Full=Ubiquinol oxidase subunit 3;
GN Name=cyoC; OrderedLocusNames=c0541;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P.,
RA Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D.,
RA Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T.,
RA Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence
RT of uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Cytochrome bo(3) ubiquinol terminal oxidase is the
CC component of the aerobic respiratory chain of E.coli that
CC predominates when cells are grown at high aeration. Has proton
CC pump activity across the membrane in addition to electron
CC transfer, pumping 2 protons/electron (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Heterooctamer of two A chains, two B chains, two C chains
CC and two D chains. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC {ECO:0000305}.
DR EMBL; AE014075; AAN79019.1; -; Genomic_DNA.
DR RefSeq; WP_000179819.1; NC_004431.1.
DR ProteinModelPortal; P0ABJ4; -.
DR STRING; 199310.c0541; -.
DR EnsemblBacteria; AAN79019; AAN79019; c0541.
DR KEGG; ecc:c0541; -.
DR PATRIC; 18279128; VBIEscCol75197_0509.
DR eggNOG; ENOG4105CCU; Bacteria.
DR eggNOG; COG1845; LUCA.
DR HOGENOM; HOG000086398; -.
DR KO; K02299; -.
DR OMA; YTELVKH; -.
DR BioCyc; ECOL199310:C0541-MONOMER; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008827; F:cytochrome o ubiquinol oxidase activity; IEA:InterPro.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR CDD; cd02863; Ubiquinol_oxidase_III; 1.
DR Gene3D; 1.20.120.80; -; 1.
DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR InterPro; IPR014206; Cyt_c_ubiqinol_oxidase_su3.
DR InterPro; IPR033946; Ubiquinol_oxase_su3_dom.
DR PANTHER; PTHR11403; PTHR11403; 1.
DR Pfam; PF00510; COX3; 1.
DR SUPFAM; SSF81452; SSF81452; 1.
DR TIGRFAMs; TIGR02842; CyoC; 1.
DR PROSITE; PS50253; COX3; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Complete proteome;
KW Electron transport; Membrane; Oxidoreductase; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 204 Cytochrome bo(3) ubiquinol oxidase
FT subunit 3.
FT /FTId=PRO_0000183894.
FT TOPO_DOM 1 31 Cytoplasmic. {ECO:0000305}.
FT TRANSMEM 32 50 Helical. {ECO:0000305}.
FT TOPO_DOM 51 66 Periplasmic. {ECO:0000305}.
FT TRANSMEM 67 85 Helical. {ECO:0000305}.
FT TOPO_DOM 86 101 Cytoplasmic. {ECO:0000305}.
FT TRANSMEM 102 120 Helical. {ECO:0000305}.
FT TOPO_DOM 121 142 Periplasmic. {ECO:0000305}.
FT TRANSMEM 143 161 Helical. {ECO:0000305}.
FT TOPO_DOM 162 184 Cytoplasmic. {ECO:0000305}.
FT TRANSMEM 185 203 Helical. {ECO:0000305}.
FT TOPO_DOM 204 204 Periplasmic. {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 16 202 ipfam:COX3 [T]
FT MYHIT 1 203 iprf:COX3 [T]
SQ SEQUENCE 204 AA; 22623 MW; F1D6ABF9EB6CB5AD CRC64;
MATDTLTHAT AHAHEHGHHD AGGTKIFGFW IYLMSDCILF SILFATYAVL VNGTAGGPTG
KDIFELPFVL VETFLLLFSS ITYGMAAIAM YKNNKSQVIS WLALTWLFGA GFIGMEIYEF
HHLIVNGMGP DRSGFLSAFF ALVGTHGLHV TSGLIWMAVL MVQIARRGLT STNRTRIMCL
SLFWHFLDVV WICVFTVVYL MGAM
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