ID CR1CA_BACTE Reviewed; 1189 AA.
AC P0A375; P05518; P10327; Q03742; Q45725;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 30-NOV-2016, entry version 38.
DE RecName: Full=Pesticidal crystal protein Cry1Ca;
DE AltName: Full=134 kDa crystal protein;
DE AltName: Full=Crystaline entomocidal protoxin;
DE AltName: Full=Insecticidal delta-endotoxin CryIC(a);
GN Name=cry1Ca; Synonyms=cryIC, cryIC(a);
OS Bacillus thuringiensis subsp. entomocidus.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1436;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=60.5;
RX PubMed=3399402; DOI=10.1093/nar/16.13.6240;
RA Honee G., van der Salm T.P.M., Visser B.;
RT "Nucleotide sequence of crystal protein gene isolated from B.
RT thuringiensis subspecies entomocidus 60.5 coding for a toxin highly
RT active against Spodoptera species.";
RL Nucleic Acids Res. 16:6240-6240(1988).
CC -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC epithelial cells of many lepidopteran larvae including Spodoptera
CC species.
CC -!- DEVELOPMENTAL STAGE: The crystal protein is produced during
CC sporulation and is accumulated both as an inclusion and as part of
CC the spore coat.
CC -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC terminus.
CC -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
DR EMBL; X07518; CAA30396.1; -; Genomic_DNA.
DR PIR; S00944; S00944.
DR ProteinModelPortal; P0A375; -.
DR SMR; P0A375; -.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.20.190.10; -; 1.
DR Gene3D; 2.100.10.10; -; 1.
DR Gene3D; 2.60.120.260; -; 1.
DR InterPro; IPR005638; Endotoxin_C.
DR InterPro; IPR001178; Endotoxin_cen_dom.
DR InterPro; IPR015790; Endotoxin_cen_dom_subgr1.
DR InterPro; IPR005639; Endotoxin_N.
DR InterPro; IPR008979; Galactose-bd-like.
DR Pfam; PF03944; Endotoxin_C; 1.
DR Pfam; PF00555; Endotoxin_M; 1.
DR Pfam; PF03945; Endotoxin_N; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF51096; SSF51096; 1.
DR SUPFAM; SSF56849; SSF56849; 1.
PE 2: Evidence at transcript level;
KW Sporulation; Toxin.
FT CHAIN 1 1189 Pesticidal crystal protein Cry1Ca.
FT /FTId=PRO_0000174036.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 261 457 ipfam:Endotoxin_M [T]
FT MYHIT 48 250 ipfam:Endotoxin_N [T]
FT MYHIT 467 614 ipfam:Endotoxin_C [T]
SQ SEQUENCE 1189 AA; 134837 MW; A68C6F986DE9A162 CRC64;
MEENNQNQCI PYNCLSNPEE VLLDGERIST GNSSIDISLS LVQFLVSNFV PGGGFLVGLI
DFVWGIVGPS QWDAFLVQIE QLINERIAEF ARNAAIANLE GLGNNFNIYV EAFKEWEEDP
NNPETRTRVI DRFRILDGLL ERDIPSFRIS GFEVPLLSVY AQAANLHLAI LRDSVIFGER
WGLTTINVNE NYNRLIRHID EYADHCANTY NRGLNNLPKS TYQDWITYNR LRRDLTLTVL
DIAAFFPNYD NRRYPIQPVG QLTREVYTDP LINFNPQLQS VAQLPTFNVM ESSRIRNPHL
FDILNNLTIF TDWFSVGRNF YWGGHRVISS LIGGGNITSP IYGREANQEP PRSFTFNGPV
FRTLSNPTLR LLQQPWPAPP FNLRGVEGVE FSTPTNSFTY RGRGTVDSLT ELPPEDNSVP
PREGYSHRLC HATFVQRSGT PFLTTGVVFS WTDRSATLTN TIDPERINQI PLVKGFRVWG
GTSVITGPGF TGGDILRRNT FGDFVSLQVN INSPITQRYR LRFRYASSRD ARVIVLTGAA
STGVGGQVSV NMPLQKTMEI GENLTSRTFR YTDFSNPFSF RANPDIIGIS EQPLFGAGSI
SSGELYIDKI EIILADATFE AESDLERAQK AVNALFTSSN QIGLKTDVTD YHIDQVSNLV
DCLSDEFCLD EKRELSEKVK HAKRLSDERN LLQDPNFRGI NRQPDRGWRG STDITIQGGD
DVFKENYVTL PGTVDECYPT YLYQKIDESK LKAYTRYELR GYIEDSQDLE IYLIRYNAKH
EIVNVPGTGS LWPLSAQSPI GKCGEPNRCA PHLEWNPDLD CSCRDGEKCA HHSHHFTLDI
DVGCTDLNED LGVWVIFKIK TQDGHARLGN LEFLEEKPLL GEALARVKRA EKKWRDKREK
LQLETNIVYK EAKESVDALF VNSQYDRLQV DTNIAMIHAA DKRVHRIREA YLPELSVIPG
VNAAIFEELE GRIFTAYSLY DARNVIKNGD FNNGLLCWNV KGHVDVEEQN NHRSVLVIPE
WEAEVSQEVR VCPGRGYILR VTAYKEGYGE GCVTIHEIED NTDELKFSNC VEEEVYPNNT
VTCNNYTGTQ EEYEGTYTSR NQGYDEAYGN NPSVPADYAS VYEEKSYTDG RRENPCESNR
GYGDYTPLPA GYVTKDLEYF PETDKVWIEI GETEGTFIVD SVELLLMEE
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