Legends: 1, CONFLICT N -> I (in Ref. 2; CAA31951). {ECO:0000305}; 2, CONFLICT V -> G (in Ref. 2; CAA31951). {ECO:0000305}; 3, CONFLICT T -> Q (in Ref. 1; AAA22343). {ECO:0000305}; 4, CONFLICT R -> A (in Ref. 2; CAA31951). {ECO:0000305}; 5, CONFLICT WPAPP -> CQRHH (in Ref. 2; CAA31951). {ECO:0000305}; 6, ipfam:Endotoxin_N [T]; 7, ipfam:Endotoxin_M [T]; 8, ipfam:Endotoxin_C [T].
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ID CR1CA_BACTA Reviewed; 1189 AA.
AC P0A376; P05518; P10327; Q03742; Q45725;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 24-JUN-2015, entry version 37.
DE RecName: Full=Pesticidal crystal protein Cry1Ca;
DE AltName: Full=134 kDa crystal protein;
DE AltName: Full=Crystaline entomocidal protoxin;
DE AltName: Full=Insecticidal delta-endotoxin CryIC(a);
GN Name=cry1Ca; Synonyms=cryIC, cryIC(a);
OS Bacillus thuringiensis subsp. aizawai.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1433;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NRRL B-18484 / PS81I;
RA Payne J.M., Sick A.J.;
RT "Bacillus thuringiensis isolate active against lepidopteran pests, and
RT genes encoding novel lepidopteran-active toxins.";
RL Patent number US5246852, 21-SEP-1993.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-823.
RC STRAIN=7-29;
RX PubMed=2548060; DOI=10.1111/j.1365-2958.1989.tb01812.x;
RA Sanchis V., Lerechus D., Menou M., Chaufaux J., Guo S., Lecadet M.-M.;
RT "Nucleotide sequence and analysis of the N-terminal coding region of
RT the Spodoptera-active delta-endotoxin gene of Bacillus thuringiensis
RT aizawai 7.29.";
RL Mol. Microbiol. 3:229-238(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-756.
RC STRAIN=7-29 / K26-21;
RA Strizhov N.;
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC epithelial cells of many lepidopteran larvae including Spodoptera
CC species.
CC -!- DEVELOPMENTAL STAGE: The crystal protein is produced during
CC sporulation and is accumulated both as an inclusion and as part of
CC the spore coat.
CC -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC terminus.
CC -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
DR EMBL; M73251; AAA22343.1; -; Genomic_DNA.
DR EMBL; X13620; CAA31951.1; -; Genomic_DNA.
DR EMBL; X96682; CAA65457.1; -; Genomic_DNA.
DR PIR; S04181; S04181.
DR ProteinModelPortal; P0A376; -.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.20.190.10; -; 1.
DR Gene3D; 2.100.10.10; -; 1.
DR Gene3D; 2.60.120.260; -; 1.
DR InterPro; IPR005638; Endotoxin_C.
DR InterPro; IPR001178; Endotoxin_cen_dom.
DR InterPro; IPR015790; Endotoxin_cen_dom_subgr1.
DR InterPro; IPR005639; Endotoxin_N.
DR InterPro; IPR008979; Galactose-bd-like.
DR Pfam; PF03944; Endotoxin_C; 1.
DR Pfam; PF00555; Endotoxin_M; 1.
DR Pfam; PF03945; Endotoxin_N; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF51096; SSF51096; 1.
DR SUPFAM; SSF56849; SSF56849; 1.
PE 2: Evidence at transcript level;
KW Sporulation; Toxin.
FT CHAIN 1 1189 Pesticidal crystal protein Cry1Ca.
FT /FTId=PRO_0000174035.
FT CONFLICT 366 366 N -> I (in Ref. 2; CAA31951).
FT {ECO:0000305}.
FT CONFLICT 376 380 WPAPP -> CQRHH (in Ref. 2; CAA31951).
FT {ECO:0000305}.
FT CONFLICT 386 386 V -> G (in Ref. 2; CAA31951).
FT {ECO:0000305}.
FT CONFLICT 405 405 T -> Q (in Ref. 1; AAA22343).
FT {ECO:0000305}.
FT CONFLICT 775 775 R -> A (in Ref. 2; CAA31951).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 48 250 ipfam:Endotoxin_N [T]
FT MYHIT 261 457 ipfam:Endotoxin_M [T]
FT MYHIT 467 614 ipfam:Endotoxin_C [T]
SQ SEQUENCE 1189 AA; 134786 MW; E8523ACE4742629C CRC64;
MEENNQNQCI PYNCLSNPEE VLLDGERIST GNSSIDISLS LVQFLVSNFV PGGGFLVGLI
DFVWGIVGPS QWDAFLVQIE QLINERIAEF ARNAAIANLE GLGNNFNIYV EAFKEWEEDP
NNPATRTRVI DRFRILDGLL ERDIPSFRIS GFEVPLLSVY AQAANLHLAI LRDSVIFGER
WGLTTINVNE NYNRLIRHID EYADHCANTY NRGLNNLPKS TYQDWITYNR LRRDLTLTVL
DIAAFFPNYD NRRYPIQPVG QLTREVYTDP LINFNPQLQS VAQLPTFNVM ESSAIRNPHL
FDILNNLTIF TDWFSVGRNF YWGGHRVISS LIGGGNITSP IYGREANQEP PRSFTFNGPV
FRTLSNPTLR LLQQPWPAPP FNLRGVEGVE FSTPTNSFTY RGRGTVDSLT ELPPEDNSVP
PREGYSHRLC HATFVQRSGT PFLTTGVVFS WTHRSATLTN TIDPERINQI PLVKGFRVWG
GTSVITGPGF TGGDILRRNT FGDFVSLQVN INSPITQRYR LRFRYASSRD ARVIVLTGAA
STGVGGQVSV NMPLQKTMEI GENLTSRTFR YTDFSNPFSF RANPDIIGIS EQPLFGAGSI
SSGELYIDKI EIILADATFE AESDLERAQK AVNALFTSSN QIGLKTDVTD YHIDQVSNLV
DCLSDEFCLD EKRELSEKVK HAKRLSDERN LLQDPNFRGI NRQPDRGWRG STDITIQGGD
DVFKENYVTL PGTVDECYPT YLYQKIDESK LKAYTRYELR GYIEDSQDLE IYLIRYNAKH
EIVNVPGTGS LWPLSAQSPI GKCGEPNRCA PHLEWNPDLD CSCRDGEKCA HHSHHFTLDI
DVGCTDLNED LGLWVIFKIK TQDNHARLGN LEFLEEKPLL GEALARVKRA EKKWRDKREK
LQLETNIVYK EAKESVDALF VNSQYDRLQV NTNIAMIHAA DKRVHRIREA YLPELSVIPG
VNAAIFEELE GRIFTAYSLY DARNVIKNGD FNNGLLCWNV KGHVDVEEQN NHRSVLVIPE
WEAEVSQEVR VCPGRGYILR VTAYKEGYGE GCVTIHEIED NTDELKFSNC VEEEVYPNNT
VTCNNYTGTQ EEYEGTYTSR NQGYDEAYGN NPSVPADYAS VYEEKSYTDG RRENPCESNR
GYGDYTPLPA GYVTKDLEYF PETDKVWIEI GETEGTFIVD SVELLLMEE
//
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