ID CR1AG_BACTU Reviewed; 1176 AA.
AC Q9S515;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 24-JUN-2015, entry version 54.
DE RecName: Full=Pesticidal crystal protein Cry1Ag;
DE AltName: Full=134 kDa crystal protein;
DE AltName: Full=Crystaline entomocidal protoxin;
DE AltName: Full=Insecticidal delta-endotoxin CryIA(g);
GN Name=cry1Ag; Synonyms=cry1, cryIA(g);
OS Bacillus thuringiensis.
OG Plasmid.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1428;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Mustafa S.A.;
RT "Cloning, nucleotide sequence and expression of a new gene encoding
RT lepidopteran-specific toxin.";
RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC epithelial cells of many lepidopteran larvae.
CC -!- DEVELOPMENTAL STAGE: The crystal protein is produced during
CC sporulation and is accumulated both as an inclusion and as part of
CC the spore coat.
CC -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC terminus.
CC -!- MISCELLANEOUS: Encoded on an unnamed plasmid. {ECO:0000305|Ref.1}.
CC -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
DR EMBL; AF081248; AAD46137.1; -; Genomic_DNA.
DR ProteinModelPortal; Q9S515; -.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.20.190.10; -; 1.
DR Gene3D; 2.100.10.10; -; 1.
DR Gene3D; 2.60.120.260; -; 1.
DR InterPro; IPR005638; Endotoxin_C.
DR InterPro; IPR001178; Endotoxin_cen_dom.
DR InterPro; IPR015790; Endotoxin_cen_dom_subgr1.
DR InterPro; IPR005639; Endotoxin_N.
DR InterPro; IPR008979; Galactose-bd-like.
DR Pfam; PF03944; Endotoxin_C; 1.
DR Pfam; PF00555; Endotoxin_M; 1.
DR Pfam; PF03945; Endotoxin_N; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF51096; SSF51096; 1.
DR SUPFAM; SSF56849; SSF56849; 1.
PE 2: Evidence at transcript level;
KW Plasmid; Sporulation; Toxin.
FT CHAIN 1 1176 Pesticidal crystal protein Cry1Ag.
FT /FTId=PRO_0000174028.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 259 443 ipfam:Endotoxin_M [T]
FT MYHIT 483 606 ipfam:Endotoxin_C [T]
FT MYHIT 50 251 ipfam:Endotoxin_N [T]
SQ SEQUENCE 1176 AA; 133394 MW; 2B5929160A2612BB CRC64;
MDNNPNINEC IPYNCLSNPE VEVLGGERIE TGYTPIDISL SLTQFLLSEF VPGAGFVLGL
VDIIWGIFGP SQWDAFLVQI EQLINQRIEE FARNQAISRL EGLSNLYQIY AESFREWEAD
PTNPALREEM RIQFNDMNSA LTTAIPLLAV QNYQVPLLSV YVQAANLHLS VLRDVSVFGQ
RWGFDAATIN SRYNDLTRLI GNYTDYAVRW YNTGLERVWG PDSRDWVRYN QFRRELTLTV
LDIVALFSNY DSRRYPIRTV SQLTREIYTN PVLENFDGSF RGMAQRIEPE YRQPHLMDIL
NSISIYTDVH RGFNYWSGHQ ITTSPVGFSG PEFTFPLYGT YGNAAPPQRI AQTGLGIFRT
LSSPLYRRII LGSGPNNQEL FVLDGTEFSF ASLTTNLPST IYRQRGTVDS LDVIPPQDNS
VPPRAGFSHR LSHVPMLSQA AGAVYTLRAS LFLLLVLLIH ARSIFNNIIP SSQITQSFKK
IISWTSVVKG PGFTGGDILR RPSPGLISTL RVNITAPLSQ RYRVRIRYAF TTNLQFLTSI
DGRPINQGNF YATMSSGSNL QSGSFRTVGF TTPFNFSNGS SVFTLSAHVF NSGNEVYIDR
IEFVPAEVTF EAEYDLERAQ NGVNQLFTSS NQIGLKTDGT DYHIDQVSNL VECLSDEFCL
DEKQELSEKV KHAKRLSDER NLLQDPNFRG INRQLDRGWR GSHDITIQGG DDVFKENYVT
LLGTFDECYP TYLYQKIDQS KLKAYTSYQL RGYIEDSQDL EIYLIGYNAK QQTVNVPGTG
SLWPVYAPKP IGKCGEPNRC APHLEWNPDL DCSCRDGEKC AHHSLHFSID IDVGCTDLNE
DLGVWVIFKI KTEDGHARLG NLEFLEEKPL VGEALARVKR AEKKWRDKRV KLEWETNIVY
KEAKESVDAL FVNSQYDQLQ ADTNIAMIHA ADKRVHSIRE AYLPELSVIP GVNAAIFEEL
EGRIFTAFSL YDARNVIKNG DFNNGLSCWN VKGHVDVEEQ NNQRSVLVVP EWEAEVSQEV
RVCPGRGYFP RVTAYKEGYG EGCVTIHEIE NNTDELKFSN CVEEEIYPNN TVTCNDYTVN
QEEYGGAYTS RNRGYNEAPS VPADYASVYE EKSYTDGRRE NPCEFNRGYR DYTGLPVGYV
TKALEYFPET DKVWIEIGET EGTFIVDSVE LLLMEE
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