ID CR1AE_BACTL Reviewed; 1181 AA.
AC Q03748;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 02-NOV-2016, entry version 66.
DE RecName: Full=Pesticidal crystal protein Cry1Ae;
DE AltName: Full=134 kDa crystal protein;
DE AltName: Full=Crystaline entomocidal protoxin;
DE AltName: Full=Insecticidal delta-endotoxin CryIA(e);
GN Name=cry1Ae; Synonyms=cryIA(e), endI;
OS Bacillus thuringiensis subsp. alesti.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1440;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1655719;
RA Lee C.S., Aronson A.I.;
RT "Cloning and analysis of delta-endotoxin genes from Bacillus
RT thuringiensis subsp. alesti.";
RL J. Bacteriol. 173:6635-6638(1991).
CC -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC epithelial cells of many lepidopteran larvae.
CC -!- DEVELOPMENTAL STAGE: The crystal protein is produced during
CC sporulation and is accumulated both as an inclusion and as part of
CC the spore coat.
CC -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC terminus.
CC -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
DR EMBL; M65252; AAA22410.1; -; Genomic_DNA.
DR PIR; A41052; A41052.
DR ProteinModelPortal; Q03748; -.
DR SMR; Q03748; -.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.20.190.10; -; 1.
DR Gene3D; 2.100.10.10; -; 1.
DR Gene3D; 2.60.120.260; -; 1.
DR InterPro; IPR005638; Endotoxin_C.
DR InterPro; IPR001178; Endotoxin_cen_dom.
DR InterPro; IPR015790; Endotoxin_cen_dom_subgr1.
DR InterPro; IPR005639; Endotoxin_N.
DR InterPro; IPR008979; Galactose-bd-like.
DR Pfam; PF03944; Endotoxin_C; 1.
DR Pfam; PF00555; Endotoxin_M; 1.
DR Pfam; PF03945; Endotoxin_N; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF51096; SSF51096; 1.
DR SUPFAM; SSF56849; SSF56849; 1.
PE 2: Evidence at transcript level;
KW Sporulation; Toxin.
FT CHAIN 1 1181 Pesticidal crystal protein Cry1Ae.
FT /FTId=PRO_0000174026.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 471 607 ipfam:Endotoxin_C [T]
FT MYHIT 259 461 ipfam:Endotoxin_M [T]
FT MYHIT 50 251 ipfam:Endotoxin_N [T]
SQ SEQUENCE 1181 AA; 133738 MW; FE86D2138C37D0FD CRC64;
MDNNPKINEC IPYNCLSNPE VEVLGGERIE TGYTPIDISL SLTQFLLSEF VPGAGFVLGL
IDLIWGFVGP SQWDAFLVQI EQLISQRIEE FARNQAISRL EGLSNLYQIY AEAFREWEAD
PTNPALREEM RIQFNDMNSA LTTAIPLFTV QNYQVPLLSV YVQAVNLHLS VLRDVSVFGQ
RWGLDVATIN SRYNDLTRLI GTYTDYAVRW YNTGLERVWG PDSRDWVRYN QFRRELTLTV
LDIVSLFPNY DSRTYPIRTV SQLTREIYTN PVLENFDGSF RGSAQRIEQS IRSPHLMDIL
NSITIYTDAH GGYYYWSGHQ IMASPVGFSG PEFTFPLYGT MGNAAPQQRI VAQLGQGVYR
TLSSTFYRNP FIIGINNQRL SVLDGTEFAY GSSSNLPSAV YRKSGTVDSL DEIPPQDNNV
PPRQGFSHRL SHVSMFRSGF SNSSVSIIRA PMFSWIHRSA EFNNIIPSSQ ITQIPLTKST
NLGSGTSVVK GPGFTGGDIL RRTSPGQIST LRVNITAPLS QRYRVRIRYA STTNLQFHTS
IDGRPINQGN FSATMSSGGN LQSGSFRTVG FTTPFNFSNG SSVFTLSAHV FNSGNEVYID
RIEFVPAEVT FEAEYDLERA QEAVNALFTS PNQIGLKTDV TDYHIDQVSN LVECLSDEFC
LDEKRELSEK VKHAKRLSDE RNLLQDPNFR GINRQPDRGW RGSTDITIQG GDDVFKENYV
TLPGTFDECY PTYLYQKIDE SKLKAYTRYE LRGYIEDSQD LEIYLIRYNA KHETVNVPGT
GSLWPLSFES SIGKCGEPNR CAPHLEWNPD LDCSCRDGEK CAHHSHHFSL DIDVGCIDLN
EDLGVWVIFK IKTQDGHARL GNLEFLEEKP LVGEALARVK RAEKKWRDKR EKLQLETNIV
YKEAKESVDA LFVNSQYDQL QADTNIAMIH TADKRVHRIQ EAYLPELSVI PGVNAGIFEE
LEGRIFTAYS LYDARNVIKN GDFNNGLSCW NVKGHVDVEE QNNHRSVLVV PEWEAEVSQE
VRVCPGRGYI LRVTAYKEGY GEGCVTIHEI ENNTDELKFS NCVEEEVYPN NTVTCNEYTA
NQEEYGGAYT SCNRGYDETY GSNYSVPADY ASVYEEKAYT DGRRENPCES NRGYGDYTPL
PAGYVTKQLE YFPETDKVWI EIGETEGTFI VDSVELFLME E
//
|
