MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Cleavage and polyadenylation specificity factor subunit 2; AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit; Short=CPSF 100 kDa subunit; |
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| MyHits synonyms | CPSF2_DICDI , Q55BS1 , B80C49B14F8926AE |
 Legends: 1, COMPBIAS Poly-Glu; 2, COMPBIAS Poly-Asn; 3, COMPBIAS Poly-Thr; 4, ismart:Beta-Casp [T]; 5, ipfam:RMMBL [T]; 6, ipfam:Beta-Casp [T].
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ID CPSF2_DICDI Reviewed; 784 AA.
AC Q55BS1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 02-NOV-2016, entry version 66.
DE RecName: Full=Cleavage and polyadenylation specificity factor subunit 2;
DE AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit;
DE Short=CPSF 100 kDa subunit;
GN Name=cpsf2; ORFNames=DDB_G0270392;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the cleavage and polyadenylation
CC specificity factor (CPSF) complex that play a key role in pre-mRNA
CC 3'-end formation, recognizing the AAUAAA signal sequence and
CC interacting with poly(A) polymerase and other factors to bring
CC about cleavage and poly(A) addition. {ECO:0000250}.
CC -!- SUBUNIT: CPSF is a heterotetramer composed of four distinct
CC subunits 160, 100, 70 and 30 kDa. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1
CC subfamily. {ECO:0000305}.
DR EMBL; AAFI02000005; EAL72546.1; -; Genomic_DNA.
DR RefSeq; XP_646760.1; XM_641668.1.
DR ProteinModelPortal; Q55BS1; -.
DR STRING; 44689.DDB0233700; -.
DR PaxDb; Q55BS1; -.
DR EnsemblProtists; EAL72546; EAL72546; DDB_G0270392.
DR GeneID; 8617733; -.
DR KEGG; ddi:DDB_G0270392; -.
DR dictyBase; DDB_G0270392; cpsf2.
DR eggNOG; KOG1135; Eukaryota.
DR eggNOG; COG1236; LUCA.
DR InParanoid; Q55BS1; -.
DR KO; K14402; -.
DR OMA; LMRNNIN; -.
DR PhylomeDB; Q55BS1; -.
DR Reactome; R-DDI-77595; Processing of Intronless Pre-mRNAs.
DR PRO; PR:Q55BS1; -.
DR Proteomes; UP000002195; Chromosome 1.
DR Proteomes; UP000002195; Unassembled WGS sequence.
DR GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; ISS:dictyBase.
DR GO; GO:0003723; F:RNA binding; ISS:dictyBase.
DR GO; GO:0006379; P:mRNA cleavage; ISS:dictyBase.
DR GO; GO:0006378; P:mRNA polyadenylation; ISS:dictyBase.
DR Gene3D; 3.60.15.10; -; 1.
DR InterPro; IPR022712; Beta_Casp.
DR InterPro; IPR027075; CPSF2.
DR InterPro; IPR025069; Cpsf2_C.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR011108; RMMBL.
DR PANTHER; PTHR11203:SF5; PTHR11203:SF5; 2.
DR Pfam; PF10996; Beta-Casp; 1.
DR Pfam; PF13299; CPSF100_C; 1.
DR Pfam; PF16661; Lactamase_B_6; 1.
DR Pfam; PF07521; RMMBL; 1.
DR SMART; SM01027; Beta-Casp; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; SSF56281; 2.
PE 3: Inferred from homology;
KW Complete proteome; mRNA processing; Nucleus; Reference proteome;
KW RNA-binding.
FT CHAIN 1 784 Cleavage and polyadenylation specificity
FT factor subunit 2.
FT /FTId=PRO_0000328361.
FT COMPBIAS 434 439 Poly-Glu.
FT COMPBIAS 676 695 Poly-Asn.
FT COMPBIAS 700 706 Poly-Thr.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 17 227 ismart:Lactamase_B [T]
FT MYHIT 247 372 ismart:Beta-Casp [T]
FT MYHIT 551 603 ipfam:RMMBL [T]
FT MYHIT 631 781 ipfam:CPSF100_C [T]
FT MYHIT 22 198 ipfam:Lactamase_B_6 [T]
FT MYHIT 247 372 ipfam:Beta-Casp [T]
SQ SEQUENCE 784 AA; 89448 MW; B80C49B14F8926AE CRC64;
MASIIKFTAL SGAKDESPPC YLLEIDDFCI LLDCGLSYNL DFSLLEPLEK VAKKIDAVLL
SHSDTTHIGG LPYVVGKYGL TGTIYGTTPV LKMGTMFLYD LYENKMSQEE FQQYSLDNID
SCFGEDRFKE LSFSQHYSLS GKGKGISITP YLAGHTIGAS VWKITKGTYS IVYAIDYNHR
NEGHLDSLQL TSDILKPSLL ITDSKGVDKT LAFKKTITRD QSLFEQINRN LRDGGNVLIP
VDTAGRVLEL LLCIENYWSK NKSLALYSVV FLGRFSFSVC QFARSQLEFM SSTASVKFEQ
NIENPFSFKH IKILSSLEEL QELPDTNKVI LTSSQDLETG FSRELFIQWC SDPKTLILFT
QKIPKDSLAD KLIKQYSTPN GRGKCIEIVQ GSRVPLTGDE LLQYEMEQAK QREEKRLEQL
RKEQEEREER ERLEEEEREQ LLNATNQDQL QQLLQLQQQK ERGIIDDSMV HMKNPFENDR
FDLLDSEFKK QSMITMFPYF EKHLKWGEYG EEDDDLILRN QDKKVEEVTM EEDEIQEQEI
PKKIITQTLR LPINCKIQTI DYEGCSDGRS IKAIIQQIAP TKLVLIRGSE QQSQSIENYV
KENIRTKGIY IPSIGEQLDL TSDTNVYELL LKDSLVNTLK TSKILDYEVS YIQGKVDILD
GSNVPVLDLI QSIPINNNNN NNNNNNNNNN NNNNNTTMMT TTTTTTNGHD ESFIGDIKLS
DLKQVLVNAG IQVQFDQGIL NCGGLVYIWR DEDHGGNSII NVDGIISDEY YLIKELLYKQ
FQIV
//
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