Entry sw:CPSF2_CAEBR

ID   CPSF2_CAEBR             Reviewed;         842 AA.
AC   A8XUS3;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   18-JAN-2017, entry version 46.
DE   RecName: Full=Probable cleavage and polyadenylation specificity factor subunit 2 {ECO:0000250|UniProtKB:O17403};
DE   AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit;
DE            Short=CPSF 100 kDa subunit;
GN   Name=cpsf-2 {ECO:0000250|UniProtKB:O17403}; ORFNames=CBG19097;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A.,
RA   D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E.,
RA   Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R.,
RA   Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P.,
RA   Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M.,
RA   Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M.,
RA   Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for
RT   comparative genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: CPSF plays a key role in pre-mRNA 3'-end formation,
CC       recognizing the AAUAAA signal sequence and interacting with
CC       poly(A)polymerase and other factors to bring about cleavage and
CC       poly(A) addition. {ECO:0000250|UniProtKB:Q9P2I0}.
CC   -!- SUBUNIT: CPSF is a heterotetramer composed of four distinct
CC       subunits 160, 100, 70 and 30 kDa. {ECO:0000250|UniProtKB:Q9P2I0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC       RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1
CC       subfamily. {ECO:0000255}.
DR   EMBL; HE601047; CAP36398.2; -; Genomic_DNA.
DR   STRING; 6238.CBG19097; -.
DR   EnsemblMetazoa; CBG19097; CBG19097; WBGene00038369.
DR   WormBase; CBG19097a; CBP45280; WBGene00038369; Cbr-cpsf-2.
DR   eggNOG; KOG1135; Eukaryota.
DR   eggNOG; COG1236; LUCA.
DR   HOGENOM; HOG000264343; -.
DR   InParanoid; A8XUS3; -.
DR   OMA; LMRNNIN; -.
DR   OrthoDB; EOG091G03GG; -.
DR   Proteomes; UP000008549; Chromosome V.
DR   Proteomes; UP000008549; Unassembled WGS sequence.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006379; P:mRNA cleavage; IEA:InterPro.
DR   GO; GO:0006378; P:mRNA polyadenylation; IEA:InterPro.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR027075; CPSF2.
DR   InterPro; IPR025069; Cpsf2_C.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR011108; RMMBL.
DR   PANTHER; PTHR11203:SF5; PTHR11203:SF5; 3.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF13299; CPSF100_C; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 2.
PE   3: Inferred from homology;
KW   Complete proteome; mRNA processing; Nucleus; Reference proteome;
KW   RNA-binding.
FT   CHAIN         1    842       Probable cleavage and polyadenylation
FT                                specificity factor subunit 2.
FT                                /FTId=PRO_0000372682.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       642    810       ipfam:CPSF100_C [T]
FT   MYHIT        22    191       ipfam:Lactamase_B_6 [T]
FT   MYHIT       242    368       ipfam:Beta-Casp [T]
FT   MYHIT        17    222       ismart:Lactamase_B [T]
FT   MYHIT       242    368       ismart:Beta-Casp [T]
FT   MYHIT       563    616       ipfam:RMMBL [T]
SQ   SEQUENCE   842 AA;  96304 MW;  EA164313DE7218DC CRC64;
     MTSIIKLKVF SGAKDEGPLC YLLQVDNDYI LLDCGWDERF ELKYFEELRP YIPKISAVLI
     SHPDPLHLGG LPYLVAKCGL TAPVYCTVPV YKMGQMFIYD LVYSHLDVEE FQHYSLDDVD
     MAFEKVEQVK YNQTVVLKGD SGVNFTAMPA GHMIGGSMWR ICRITGEDII YCVDFNHRKD
     RHLSGCSFDN FNRPHLLITG AHHISLPQMK RKDRDEQLVT KILRTVRQKG DCMIVIDTAG
     RVLELAYLLD QLWANQDAGL STYNLVMMSH VASSVVQFAK SQLEWMDEKL FRYDSSSARY
     NPFTLKNVNL VHSHLELIKI RSPKVVLCSS QDMETGFSRE LFLDWCADQR NGVILTARPA
     SFTLAARLVE LAERANDGVL RNEDKHLSLL VRKRVPLEGE ELLEYKRRKA ERDAEETRIR
     MERARRQAQA NESDDSDDDD IAAPIVPRLS EKDHRSFDAI ENDSHCFDIM AKWDNQQKAS
     FFKSTKKSFP MYPYIEEKVK WDDYGEVIKP EDYTVISKID MRKGKNKDEP VVVHKREDEE
     EVYNPNDHDE EMPTKCVEFR NRIEISCRVE FIEYEGISDG ESTKKMLAGL MPRQIIIVHG
     SRDDTRDLYA YFTDNGFKKD QLNTPVANEL IDASVESFIY QVSLSDALLA EIQFKEVSEG
     NSLAWIDARI QEKESIDNML VAGASQLTIE DSLQEDAVEV VEEDVIPMET FQDDQNKQEA
     SEENVAEGEK SNGQSKENDE NASSIPIETQ PKIRGTLILT PLPKKQIPVH QAIFVNDPKL
     SEFKNLLVDK GYKAEFFSGT LLINGGKCSI LVERLDSKWR VLSQKTFTNF GSCSTTSLLF
     CK
//